DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment OTX2 and otp

DIOPT Version :9

Sequence 1:	NP_001257454.1	Gene:	OTX2 / 5015	HGNCID:	8522	Length:	297	Species:	Homo sapiens
Sequence 2:	NP_001286654.1	Gene:	otp / 37364	FlyBaseID:	FBgn0015524	Length:	416	Species:	Drosophila melanogaster

Alignment Length:	225	Identity:	73/225 - (32%)
Similarity:	105/225 - (46%)	Gaps:	45/225 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    45 KQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQ 109
            ||:|.||.||.|||:.||..|:||.|||||||||:|::|.|.||||||||:|||||.:::
  Fly   115 KQKRHRTRFTPAQLNELERCFSKTHYPDIFMREEIAMRIGLTESRVQVWFQNRRAKWKKR----- 174

Human   110 NGGQNKVRPAKKKTSPAREVSSESGTSGQFTPPSSTSVPTIASSSAPVSI-------WSPASISP 167
                      ||.|:..|...:...:.|  .||...::..||........       ||..
  Fly   175 ----------KKTTNVFRTPGALLPSHG--LPPFGANITNIAMGDGLCGTGMFGGDRWSVG---- 223

Human   168 LSDPLSTSSSCMQRSYPMTYTQASGYSQGY-------AGSTSYFGGMDCGSYLTPMHHQLPGPGA 225
             .:|::.....:.:|.|::.:..||.:.|.       |||..::|....|.   .|.:|....|.
  Fly   224 -VNPMTAGFGQLNQSSPLSSSLNSGLNSGINMGSALGAGSYQHYGLNALGD---SMMYQHSVGGV 284

Human   226 TLSPMGTNAVTSHLNQ------SPASLSTQ 249
            :..|.|:.:.|:..|.      :|..||.|
  Fly   285 SCGPSGSPSATTPPNMNSCSSVTPPPLSAQ 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OTX2	NP_001257454.1	Homeobox	50..102	CDD:395001	37/51 (73%)
OTX2	NP_001257454.1	TF_Otx	163..242	CDD:397546	18/91 (20%)
otp	NP_001286654.1	Homeobox	119..167	CDD:278475	32/47 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	100	1.000	Inparanoid score	I5000
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960