Protein Alignment OTX2 and prd

DIOPT Version :10

• Sequence 1: NP_068374.1
• Gene: OTX2 / 5015
• HGNCID: 8522
• Length: 297
• Species: Homo sapiens
• Sequence 2: NP_723721.1
• Gene: prd / 34629
• FlyBaseID: FBgn0003145
• Length: 613
• Species: Drosophila melanogaster
• Alignment Length: 296
• Identity: 90/296 - (30%)
• Similarity: 132/296 - (44%)
• Gaps: 53/296 - (17%)

Human    11 AVNGLSLTTS-GMDLL--HPSVGYPG--PWASCPA----ATPRKQRRERTTFTRAQLDVLEALFA 66
            |.:|...::| |.|:.  |.:.|.|.  ..:.|.:    |..|||||.||||:.:|||.||..|.
  Fly   169 AGDGTKASSSCGSDVSGGHHNNGKPSDEDISDCESEPGIALKRKQRRCRTTFSASQLDELERAFE 233

Human    67 KTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAKKKTSPAREVSS 131
            :|:||||:.|||:|.:.||.|:|:||||.||||:.|:|......|.     |.....|.:...:|
  Fly   234 RTQYPDIYTREELAQRTNLTEARIQVWFSNRRARLRKQHTSVSGGA-----PGGAAASVSHVAAS 293

Human   132 ESGTSGQFTPPSSTSVPTIASSSAPVSIW------------------SPASISPLSDPLSTSSSC 178
            .|..|...:.||...:..:..|..|.:::                  :|.:.|.||..::|:...
  Fly   294 SSLPSVVSSVPSMAPLAMMPGSLDPATVYQQQYDFYGSHANISVSAAAPMASSNLSPGITTTPPH 358

Human   179 MQRSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPM----------HHQLP---GPGATLSPM 230
            ..:.|..:...||....|..|:|:..|.:...||.|.:          |..:|   .|..::|
  Fly   359 HHQFYNPSANTASYIMPGENGNTTPTGNIIVSSYETQLGSVYGTETETHQTMPRNESPNESVS-- 421

Human   231 GTNAVTSHLNQSPASLSTQGYGA---SSLGFNSTTD 263
               :....|..:|.|||....||   ||.|.||..|
  Fly   422 ---SAFGQLPPTPNSLSAVVSGAGVTSSSGANSGAD 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OTX2	NP_068374.1	Homeodomain	47..102	CDD:459649	33/54 (61%)
		TF_Otx	161..242	CDD:427350	20/93 (22%)
prd	NP_723721.1	PAX	27..154	CDD:238076
		Homeodomain	214..270	CDD:459649	33/55 (60%)