Protein Alignment OTX2 and CG32532

DIOPT Version :10

• Sequence 1: NP_068374.1
• Gene: OTX2 / 5015
• HGNCID: 8522
• Length: 297
• Species: Homo sapiens
• Sequence 2: NP_608318.5
• Gene: CG32532 / 32943
• FlyBaseID: FBgn0052532
• Length: 688
• Species: Drosophila melanogaster
• Alignment Length: 231
• Identity: 75/231 - (32%)
• Similarity: 103/231 - (44%)
• Gaps: 50/231 - (21%)

Human     3 SYLKQPPYAVNGLSLTT-------SGMDLLHPSVGYPGPWASCPAATPRKQRRERTTFTRAQLDV 60
            ::.|..|...:|||..:       ||:..|....|:....||||  ||.: ||.|||||:.||..
  Fly   463 AFKKLKPEPNSGLSTVSAGITSPGSGLSSLSQHAGHTPTTASCP--TPAR-RRHRTTFTQEQLAE 524

Human    61 LEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQ-----------NGGQN 114
            |||.|||:.||||:.|||:|....|.|:|:||||:|||||.|:|::|.|           ||...
  Fly   525 LEAAFAKSHYPDIYCREELARTTKLNEARIQVWFQNRRAKYRKQEKQLQKALAPSVIPSCNGMMR 589

Human   115 KV---------RPAKKKTSPAR--------EVSSESGTSGQFTPPSSTSVPTIA---------SS 153
            .:         :|.....:..|        ..||..|.:..|:...||::.::.         ..
  Fly   590 NIQGYSVSRGYQPYPHHNTMNRYPQDLFQMGASSYPGMTQPFSMAHSTNMGSVGVRQDSMGEFHG 654

Human   154 SAPVSIWSPASISPLSDPLSTSSSCMQRSYPMTYTQ 189
            .:|...|...|:|.|.   ..||.....|.||...|
  Fly   655 MSPEDEWYNKSLSALR---MNSSHHPNLSAPMLQYQ 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OTX2	NP_068374.1	Homeodomain	47..102	CDD:459649	35/54 (65%)
		TF_Otx	161..242	CDD:427350	9/29 (31%)
CG32532	NP_608318.5	Homeodomain	511..567	CDD:459649	35/55 (64%)