Protein Alignment OTX2 and oc

DIOPT Version :10

• Sequence 1: NP_068374.1
• Gene: OTX2 / 5015
• HGNCID: 8522
• Length: 297
• Species: Homo sapiens
• Sequence 2: NP_001356934.1
• Gene: oc / 31802
• FlyBaseID: FBgn0004102
• Length: 664
• Species: Drosophila melanogaster
• Alignment Length: 322
• Identity: 115/322 - (35%)
• Similarity: 144/322 - (44%)
• Gaps: 80/322 - (24%)

Human     8 PPYAVNGLSLTTSG-MDLLH--PSVGY-PGPWASCPAATPRKQRRERTTFTRAQLDVLEALFAKT 68
            ||    |:.:.:.| ..|.|  .:||: .|.|    ....||||||||||||||||||||||.||
  Fly    33 PP----GMPMPSLGPFGLPHGLEAVGFSQGMW----GVNTRKQRRERTTFTRAQLDVLEALFGKT 89

Human    69 RYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQ------------------------ 109
            ||||||||||||||||||||||||||||||||||||.||||
  Fly    90 RYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQLQQQQQSNSLSSSKNASGGGSGNSCSSSS 154

Human   110 --------------------NGGQNKVRPAKKKTSPAREVSSESGTSGQFTPPSSTSVPTIASSS 154
                                :||.|..:.::|:.:  .:.|.:.|.|......::.|....||::
  Fly   155 ANSRSNSNNNGSSSNNNTQSSGGNNSNKSSQKQGN--SQSSQQGGGSSGGNNSNNNSAAAAASAA 217

Human   155 APV----SIWSPASISPLSDPLSTSSSCMQRSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYL-- 213
            |.|    ||.:..|....:...:.|....|.:...:.....|.|...:.|:...||...|.:|
  Fly   218 AAVAAAQSIKTHHSSFLSAAAAAASGGTNQSANNNSNNNNQGNSTPNSSSSGGGGGSQAGGHLSA 282

Human   214 ---------TPMHHQ----LPGPGATLSPMGTNAVTSHLN---QSPASLSTQGYGASSLGFN 259
                     |..|..    ||.|..::||:.......||:   .|.......|.||||.|.|
  Fly   283 AAAAAALNVTAAHQNSSPLLPTPATSVSPVSIVCKKEHLSGGYGSSVGGGGGGGGASSGGLN 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OTX2	NP_068374.1	Homeodomain	47..102	CDD:459649	53/54 (98%)
		TF_Otx	161..242	CDD:427350	19/98 (19%)
oc	NP_001356934.1	Homeodomain	68..123	CDD:459649	53/54 (98%)