Protein Alignment OTX2 and Vsx1

DIOPT Version :10

• Sequence 1: NP_068374.1
• Gene: OTX2 / 5015
• HGNCID: 8522
• Length: 297
• Species: Homo sapiens
• Sequence 2: NP_572232.2
• Gene: Vsx1 / 31470
• FlyBaseID: FBgn0263511
• Length: 837
• Species: Drosophila melanogaster
• Alignment Length: 309
• Identity: 72/309 - (23%)
• Similarity: 113/309 - (36%)
• Gaps: 101/309 - (32%)

Human    17 LTTSGMDLLHPSVGYPGPWASCPAATPRKQRRE-RTTFTRAQLDVLEALFAKTRYPDIFMREEVA 80
            |...|.|:|      .||..:.|....:.:||. ||.||.:||:.||..|.:..|||:..||.::
  Fly   371 LAAHGGDVL------VGPGGTGPGGKKKNKRRHGRTIFTSSQLEELEKAFKEAHYPDVSARELLS 429

Human    81 LKINLPESRVQVWFKNRRAKCRQQQ-------QQQQNG------------GQNKVRPAK------ 120
            :|..|.|.|:|||::|||||.|:.:       :..:.|            .:..::.||
  Fly   430 MKTGLAEDRIQVWYQNRRAKWRKTEKCWGHSTKMAEYGLYGAMVRHSLPLPETIIKSAKEDESVA 494

Human   121 -------KKTSPAREVSSESGTSGQFTPPS---STSVPTIASSSAPVSIWSPASISPLSDPLSTS 175
                   ||:..|.|: .:|..|.:.||.|   :||....::.::|:|.:|.:.:...:.|.:..
  Fly   495 PWLLGMHKKSLEAAEL-LKSDESDRETPTSDDTNTSYSAGSTHNSPISSFSISRLLFDAPPPAAG 558

Human   176 SS-------------------------------------------CMQRSYPMTYTQASGYSQGY 197
            |:                                           ..|..:.:...:.|...|..
  Fly   559 SAGGKGHHHHHHHHKGHHHAHVHAQAQAHAHMLLHHQQQQQQQQQQQQHHHHLHAAENSLQQQQV 623

Human   198 AGSTSYFG-----GMDCGSYLTPMHHQLPGPGATLSPMGTNAVTSHLNQ 241
            ||:.|..|     |...||...|.||          |........||.|
  Fly   624 AGTGSGSGSGSGSGTGAGSTGPPAHH----------PYNQQQHLHHLQQ 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OTX2	NP_068374.1	Homeodomain	47..102	CDD:459649	28/55 (51%)
		TF_Otx	161..242	CDD:427350	20/129 (16%)
Vsx1	NP_572232.2	Homeodomain	395..452	CDD:459649	28/56 (50%)