Protein Alignment OTX2 and Vsx2

DIOPT Version :10

• Sequence 1: NP_068374.1
• Gene: OTX2 / 5015
• HGNCID: 8522
• Length: 297
• Species: Homo sapiens
• Sequence 2: NP_001284897.1
• Gene: Vsx2 / 31469
• FlyBaseID: FBgn0263512
• Length: 645
• Species: Drosophila melanogaster
• Alignment Length: 297
• Identity: 79/297 - (26%)
• Similarity: 113/297 - (38%)
• Gaps: 102/297 - (34%)

Human    44 RKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQ 108
            :|:|..||.||..||:.||..|.:..|||::.||.::||..|||.|:||||:|||||.|:.::..
  Fly   228 KKRRHSRTIFTSYQLEKLEEAFKEAHYPDVYAREMLSLKTELPEDRIQVWFQNRRAKWRKTEKVW 292

Human   109 QNGG------------------------------QNKVRP----------AKKKTSPAREVSSES 133
              ||                              .:.|.|          .:|.......:..:|
  Fly   293 --GGSTIMAEYGLYGAMVRHSLPLPDTILKSAKDNDAVAPWLLGMEQKCMHRKSIEAQSALKDDS 355

Human   134 GTSGQFTPPSSTSVPT----------IASSSAPVSIWSPASISPLSDPLSTSSSCMQRSYPMTYT 188
            |.|.......|.|..:          ::||:..:::.|||   |.|.|.|.|:|.     |.|.|
  Fly   356 GVSDHEDSAGSKSAHSEDLSRSRCHALSSSTESLNVVSPA---PSSCPTSASTSA-----PPTST 412

Human   189 QASGYSQGYAG-----STSYFGGMDCGSYLTPMHHQLPGPGATLSP------------------- 229
                  .||||     :|:..|.....|..:| |.:|..|    ||
  Fly   413 ------SGYAGAASSAATTPTGASTTNSSSSP-HIELGSP----SPQQQQHLQLQQQQQQQASLY 466

Human   230 MGTNAVTS-------HLNQSPASLSTQGYGASSLGFN 259
            :|..||.:       |.....|:.:..|..|||..|:
  Fly   467 LGAGAVVTGCAPPSYHPLLDAANAAGAGAAASSKDFH 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OTX2	NP_068374.1	Homeodomain	47..102	CDD:459649	30/54 (56%)
		TF_Otx	161..242	CDD:427350	29/111 (26%)
Vsx2	NP_001284897.1	Homeodomain	230..287	CDD:459649	30/56 (54%)
		OAR	556..572	CDD:461067