Protein Alignment OTX1 and Drgx

DIOPT Version :10

• Sequence 1: NP_055377.1
• Gene: OTX1 / 5013
• HGNCID: 8521
• Length: 354
• Species: Homo sapiens
• Sequence 2: NP_001097075.2
• Gene: Drgx / 5740176
• FlyBaseID: FBgn0085369
• Length: 587
• Species: Drosophila melanogaster
• Alignment Length: 590
• Identity: 137/590 - (23%)
• Similarity: 194/590 - (32%)
• Gaps: 264/590 - (44%)

Human     1 MMSYLKQPPYGMNGLGLAGPAMDLL-------HPSVGYPATP---------RKQRRERTTFTRSQ 49
            |..|  |.|..::..|...|.:..|       ||...|...|         |||||.|||||..|
  Fly     1 MFCY--QCPPALHPCGPHPPRLPTLDYPFAATHPYTSYSYHPAIHDETFVRRKQRRNRTTFTLQQ 63

Human    50 LDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCR---------QQQQSGSGTKS 105
            |:.||..||:|.|||:|.||::|:||||.|:||||||:|||||.|         :::::|..:.|
  Fly    64 LEELETAFAQTHYPDVFTREDLAMKINLTEARVQVWFQNRRAKWRKAERLKDEQRKRENGESSSS 128

Human   106 -------------------------RPAKKKSSPVR--------------------------ESS 119
                                     .|.::..||:.                          :||
  Fly   129 LDKLHDSRESSPDITGEIDDDMDDLPPRQRSHSPLANGQMEQQHSHSHSHSHSRSPGGGMHLDSS 193

Human   120 GSE---SSGQFTPPAVSSSASSS-SSASSSSANPA--------AAAAAGLGGNPVAAASSLSTPA 172
            .:|   ||.|.|  |...|||.| .|.|:.|.:|:        .....|.|..|.:.::|.:|.:
  Fly   194 DNERPLSSNQLT--ATPHSASQSLGSISAGSPSPSGMHREREHTPLVGGGGQGPSSPSNSRNTDS 256

Human   173 ASSIWSPASISPGSAPA------SVSVPEPLA--AP---------------------------SN 202
            ...:..|.|::.||..|      :.|.|.|..  ||                           |:
  Fly   257 PIEVGGPMSLTTGSRMAASSNNSASSTPTPTTPHAPQMPHSSAAAAAAFGSHIFGNFGGGSNASD 321

Human   203 TSC-------MQRSVAAGAATAAA----------------------------------------- 219
            ::|       .|.:|||.||.|||
  Fly   322 SNCGFRPVLSEQSAVAAAAAAAAAQRSANHPPLFLPPHLAAQFTHQPLFPGLKGVSPFQSLCSCC 386

Human   220 ----------------SYPMSYGQGGSYGQGYPTPSSSYFGGV--DCSSYLAPMHSHHHPH---- 262
                            |.|:|.....|..:   :|.||..|.|  ..|:.:|.:......|
  Fly   387 SLKPPPPPGSSVVAPLSIPVSSSSAASSPE---SPKSSGQGSVHDPRSNSVAELRRKAQEHSAAL 448

Human   263 --QLSPMAPSSMAGHHHHHP---HAHHPLSQSSGHHHHHHHHHH--------------------- 301
              .|...|.:.:|....|.|   .||||   :.|.|..:|::::
  Fly   449 LQSLHAAAAAGLAFPGLHLPPLSFAHHP---ALGQHVVNHNNNNTMRMKHEAQDMTMNGLGPGSG 510

Human   302 --QGYGGSGLAFNSADCLDYKE---------------------------------PGAAAASSAW 331
              .|.|.:|...:||..||..|                                 ||:.|.:.:.
  Fly   511 SGSGSGSAGGGTSSAALLDLAESAVAYQQQQHATLSPPTTPTQQSSGGVAATEGSPGSGAIAGSG 575

Human   332 KLNFN 336
            .||.|
  Fly   576 SLNGN 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OTX1	NP_055377.1	Homeodomain	39..95	CDD:459649	38/64 (59%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..146		22/118 (19%)
		TF_Otx	178..274	CDD:427350	35/202 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..305		14/79 (18%)
Drgx	NP_001097075.2	Homeodomain	53..109	CDD:459649	37/55 (67%)
		OAR	428..446	CDD:461067	3/17 (18%)