Protein Alignment OTX1 and hbn

DIOPT Version :10

• Sequence 1: NP_055377.1
• Gene: OTX1 / 5013
• HGNCID: 8521
• Length: 354
• Species: Homo sapiens
• Sequence 2: NP_788420.1
• Gene: hbn / 47894
• FlyBaseID: FBgn0008636
• Length: 409
• Species: Drosophila melanogaster
• Alignment Length: 333
• Identity: 94/333 - (28%)
• Similarity: 128/333 - (38%)
• Gaps: 111/333 - (33%)

Human    35 PRKQRRERTTFTRSQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQS 99
            |||.||.|||||..||..||..|.||:|||:|.||::|::::|.|:||||||:|||||.|::::.
  Fly   150 PRKVRRSRTTFTTFQLHQLERAFEKTQYPDVFTREDLAMRLDLSEARVQVWFQNRRAKWRKREKF 214

Human   100 GSGTKSR---------------PAKKKSSPVRESSGSESSGQFTPPAVSSSASSSSSASSSSANP 149
            .:..|:.               |......|....|   ...:|.||         ..|.....||
  Fly   215 MNQDKAGYLLPEQGLPEFPLGIPLPPHGLPGHPGS---MQSEFWPP---------HFALHQHFNP 267

Human   150 AAAAAAGLGGNPVAAASSLSTPAASSIWSPASISPGSAPASVSVPEPLAAP-------------- 200
            ||||||||                                   :|:.|.||
  Fly   268 AAAAAAGL-----------------------------------LPQHLMAPHYKLPNFHTLLSQY 297

Human   201 SNTSCMQRSVAAGAATAAASYPMSYGQGGSYGQGYPTPSSSYFGGVDCSSYLAPMHSHHHPHQLS 265
            ...|.:.....||||.|||          :...||| .:.|...|:...|.::|..|:..|.:..
  Fly   298 MGLSNLNGIFGAGAAAAAA----------AASAGYP-QNLSLHAGLSAMSQVSPPCSNSSPRESP 351

Human   266 PMAPSSMAGHHHHHPHAHHPLSQSSGHHHHHHHHHHQGYGGSGLAFNSADCLDYKEPGAAAASSA 330
            .:.|      |...|||..|..               |.||.||..........:.|.:||.:|:
  Fly   352 KLVP------HPTPPHATPPAG---------------GNGGGGLLTGGLISTAAQSPNSAAGASS 395

Human   331 WKLNFNSP 338
               |.::|
  Fly   396 ---NASTP 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OTX1	NP_055377.1	Homeodomain	39..95	CDD:459649	34/55 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..146		11/69 (16%)
		TF_Otx	178..274	CDD:427350	22/109 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..305		9/47 (19%)
hbn	NP_788420.1	Homeodomain	154..210	CDD:459649	34/55 (62%)