Protein Alignment OTX1 and Rx

DIOPT Version :10

• Sequence 1: NP_055377.1
• Gene: OTX1 / 5013
• HGNCID: 8521
• Length: 354
• Species: Homo sapiens
• Sequence 2: NP_726006.3
• Gene: Rx / 37367
• FlyBaseID: FBgn0020617
• Length: 904
• Species: Drosophila melanogaster
• Alignment Length: 321
• Identity: 98/321 - (30%)
• Similarity: 130/321 - (40%)
• Gaps: 88/321 - (27%)

Human    36 RKQRRERTTFTRSQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQSG 100
            :|.||.|||||..||..||..|.|:.|||::.|||:|:|:||||.||||||:|||||.|:|::|.
  Fly   557 KKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKSE 621

Human   101 SGTKSRPAKKKSSPVRESSGSESSGQFTPPAVSSSASSSSSASSSSANPAAAAAAGLGGNPVAAA 165
            |   .|......:.:....|..:||....|.:|.              |..:|..|...:|....
  Fly   622 S---LRLGLTHFTQLPHRLGCGASGLPVDPWLSP--------------PLLSALPGFLSHPQTVY 669

Human   166 SSLSTPAASSIWSPASISPGSAPASVSVPEPLAAPSNTSCMQRSVAA-GAATAAASYPMSYGQGG 229
            .|..||       |.|::||:...|                  |:|| |...|....|..:...|
  Fly   670 PSYLTP-------PLSLAPGNLTMS------------------SLAAMGHHHAHNGPPPPHVGHG 709

Human   230 SYGQGYPTPSSSYFGGVDCSSYLAPMHSHHHPHQLSPMAPSSMAGHHHHHPHAH---HPLSQSSG 291
            .:||..|.|.             .|.|...|||           |.||..|.:|   | ||:.|.
  Fly   710 GHGQPQPPPP-------------PPPHGVPHPH-----------GSHHVVPLSHLSPH-LSRMSP 749

Human   292 HHHHHHHHHHQGYGGSGLAFNSADCLDYKEPGAAA----------ASSAWKLNFNSPD-CL 341
            |.......|| |....|...:|:     ..|.:.|          :||:..|..:.|| |:
  Fly   750 HATSLGSPHH-GVTPLGTPLHSS-----LPPSSTATTVAVSSSQSSSSSASLECSGPDVCM 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OTX1	NP_055377.1	Homeodomain	39..95	CDD:459649	36/55 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..146		12/54 (22%)
		TF_Otx	178..274	CDD:427350	21/96 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..305		16/50 (32%)
Rx	NP_726006.3	Homeodomain	560..616	CDD:459649	36/55 (65%)
		OAR	876..892	CDD:461067