Protein Alignment OTX1 and eve

DIOPT Version :10

• Sequence 1: NP_055377.1
• Gene: OTX1 / 5013
• HGNCID: 8521
• Length: 354
• Species: Homo sapiens
• Sequence 2: NP_523670.2
• Gene: eve / 36039
• FlyBaseID: FBgn0000606
• Length: 376
• Species: Drosophila melanogaster
• Alignment Length: 315
• Identity: 84/315 - (26%)
• Similarity: 116/315 - (36%)
• Gaps: 97/315 - (30%)

Human     5 LKQPPYGMNG-LGLAGPAMDLLHPSVGYPATPRKQRRERTTFTRSQLDVLEALFAKTRYPDIFMR 68
            |..|...:|| .|...||    .|||         ||.||.|||.||..||..|.|..|.....|
  Fly    49 LSSPDNSLNGSRGSEIPA----DPSV---------RRYRTAFTRDQLGRLEKEFYKENYVSRPRR 100

Human    69 EEVALKINLPESRVQVWFKNRRAKCRQQQQSGSGTKSRPAKKKSSPVRESSGSESSGQFTPPAVS 133
            .|:|.::|||||.::|||:|||.|.::|:                              ...|..
  Fly   101 CELAAQLNLPESTIKVWFQNRRMKDKRQR------------------------------IAVAWP 135

Human   134 SSASSSSSASSSSANPAAAAAAGLGGNPVAAASSLSTPAASSIWSPASISPGSAPASVSVPEPLA 198
            .:|..|..|.::|...|||.:.|:...|.|.|::.:..||:::.:...::.|..|  :.:|:
  Fly   136 YAAVYSDPAFAASILQAAANSVGMPYPPYAPAAAAAAAAAAAVATNPMMATGMPP--MGMPQ--- 195

Human   199 APSNTSCMQRSVAAGAATAAASYPMSYGQGGSYGQGYPTPSSSYFGGVDCSSYLAPMHSHHHPHQ 263
                                  .|.....|.|...|:|:|...|        ...|.|....|
  Fly   196 ----------------------MPTMQMPGHSGHAGHPSPYGQY--------RYTPYHIPARP-- 228

Human   264 LSPMAPSSMAGHHHHHPHAHHPLSQSSGHHHHHHHHHHQGYGGSGL--AFNSADC 316
                ||...||.|.||||.....:..|.:          ..|.:||  |..||.|
  Fly   229 ----APPHPAGPHMHHPHMMGSSATGSSY----------SAGAAGLLGALPSATC 269

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OTX1	NP_055377.1	Homeodomain	39..95	CDD:459649	29/55 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..146		6/54 (11%)
		TF_Otx	178..274	CDD:427350	15/95 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..305		11/47 (23%)
eve	NP_523670.2	Homeodomain	71..127	CDD:459649	29/55 (53%)