Protein Alignment OTX1 and unc-4

DIOPT Version :10

• Sequence 1: NP_055377.1
• Gene: OTX1 / 5013
• HGNCID: 8521
• Length: 354
• Species: Homo sapiens
• Sequence 2: NP_573242.2
• Gene: unc-4 / 32757
• FlyBaseID: FBgn0024184
• Length: 588
• Species: Drosophila melanogaster
• Alignment Length: 419
• Identity: 101/419 - (24%)
• Similarity: 145/419 - (34%)
• Gaps: 135/419 - (32%)

Human     8 PPYGMNGLGLAGPAMDLLHPSVGYP------ATPRKQRRERTTFTRSQLDVLEALFAKTRYPDIF 66
            ||        |||..:..:...|:|      ::..|:||.||.|...||:.||..|:.:.|||||
  Fly   215 PP--------AGPPSEGSNEDGGFPGDGDDDSSAAKRRRSRTNFNSWQLEELERAFSASHYPDIF 271

Human    67 MREEVALKINLPESRVQVWFKNRRAKCRQQQQSGSGTKSRPAKKKSSPVRESSGSESSGQFTPP- 130
            |||.:|::::|.||||.|||:|||||.|:::.    ||..|.:    |...:.....||:..||
  Fly   272 MREALAMRLDLKESRVAVWFQNRRAKVRKREH----TKKGPGR----PAHNAQPQTCSGEPIPPN 328

Human   131 ----------------AVSSSA------------------------------------------- 136
                            |:...|
  Fly   329 ELKAKERARRRKKLAKAIDRQARKLQAKGITVDLEALKAEYISQHKANGTFSDSDLEDDGIQIDV 393

Human   137 ----SSSSSASSSSANPAAAAAAGLGGNPV------AAASSL---------STPAASSIWSPASI 182
                .|.....|.:.:|......|.||...      .|:|||         |:.|.|.|....|:
  Fly   394 VGGTDSDDEGDSDAVSPVRLGGGGGGGGGTGGGGGGGASSSLHCGLDGDGDSSRAGSFIGGGGSL 458

Human   183 SPGSAPASVSVPEPLAAPSNTSCMQRSVAAGAATAAASYPMSYGQGGSYGQGYPTPSSSYFGGVD 247
               .:|:||:.|..|   ||          ||.......||...:.....:...:|....| ...
  Fly   459 ---GSPSSVAPPSML---SN----------GAVQFGKLEPMDGNESEERDRERDSPKPLLF-PAK 506

Human   248 CSSYLAPMHSHHHPHQLSPMAPSSMAGHHHHHPHAHHPLSQSSGHHHHHHHHH-HQGYGGSGLAF 311
            ....|....|..|...:......|.:||.|             ||.|:||.|| |.|...:..|.
  Fly   507 AFHQLNLQSSQQHHGLVVGQGQGSGSGHGH-------------GHQHNHHQHHLHHGSASASAAA 558

Human   312 NSADCLDYKEPGAAAASSAWKLN---FNS 337
            ..|:.:....|.:...|:.:.:.   ||:
  Fly   559 AVANLVHQTSPISMRRSNPFSIESLLFNN 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OTX1	NP_055377.1	Homeodomain	39..95	CDD:459649	32/55 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..146		15/118 (13%)
		TF_Otx	178..274	CDD:427350	18/95 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..305		15/48 (31%)
unc-4	NP_573242.2	Homeodomain	244..300	CDD:459649	32/55 (58%)