Protein Alignment OTX1 and oc

DIOPT Version :10

• Sequence 1: NP_055377.1
• Gene: OTX1 / 5013
• HGNCID: 8521
• Length: 354
• Species: Homo sapiens
• Sequence 2: NP_001356934.1
• Gene: oc / 31802
• FlyBaseID: FBgn0004102
• Length: 664
• Species: Drosophila melanogaster
• Alignment Length: 501
• Identity: 146/501 - (29%)
• Similarity: 194/501 - (38%)
• Gaps: 173/501 - (34%)

Human     9 PYGMNGLGLAGPAMDLLHPSVG-YPATPRKQRRERTTFTRSQLDVLEALFAKTRYPDIFMREEVA 72
            |:|:..:|.          |.| :....||||||||||||:|||||||||.||||||||||||||
  Fly    47 PHGLEAVGF----------SQGMWGVNTRKQRRERTTFTRAQLDVLEALFGKTRYPDIFMREEVA 101

Human    73 LKINLPESRVQVWFKNRRAKCR----QQQQSGSGTKSRPAKK-------KSSPVRESSGSESSGQ 126
            ||||||||||||||||||||||    |||||.|.:.|:.|..       .||.....|.|.::|.
  Fly   102 LKINLPESRVQVWFKNRRAKCRQQLQQQQQSNSLSSSKNASGGGSGNSCSSSSANSRSNSNNNGS 166

Human   127 FTPPAVSSSASSSSSASS------------------SSANPAAAAAAGLGGNPVAAASSLSTPAA 173
            .:.....||..::|:.||                  :::|..:||||......||||.|:.|..:
  Fly   167 SSNNNTQSSGGNNSNKSSQKQGNSQSSQQGGGSSGGNNSNNNSAAAAASAAAAVAAAQSIKTHHS 231

Human   174 SSIWSPASISPG-----------------SAPAS--------------VSVPEPLAAPSNTSCMQ 207
            |.:.:.|:.:.|                 |.|.|              :|.....||.:.|:..|
  Fly   232 SFLSAAAAAASGGTNQSANNNSNNNNQGNSTPNSSSSGGGGGSQAGGHLSAAAAAAALNVTAAHQ 296

Human   208 RSVAAGAATAAASYPMS-----------YGQ--GGSYGQGYPTPSSSYFG---------GVDCSS 250
            .|.......|.:..|:|           ||.  ||..|.|..:......|         ||..|.
  Fly   297 NSSPLLPTPATSVSPVSIVCKKEHLSGGYGSSVGGGGGGGGASSGGLNLGVGVGVGVGVGVGVSQ 361

Human   251 YL----------------APMHSHH---------HPHQL----------------------SPMA 268
            .|                |.:|.||         :|..|                      :||:
  Fly   362 DLLRSPYDQLKDAGGDIGAGVHHHHSIYGSAAGSNPRLLQPGGNITPMDSSSSITTPSPPITPMS 426

Human   269 PSSMAGHHH--------HHPHAHHPLSQSSGHHHHHHHHHHQGYGGSGLA----------FNSAD 315
            |.|.|...|        ||..||.....|:...::..|:.:|.|..:...          |::.:
  Fly   427 PQSAAAAAHAAQSAQSAHHSAAHSAAYMSNHDSYNFWHNQYQQYPNNYAQAPSYYSQMEYFSNQN 491

Human   316 CLDYK---------------EPGAAAASSAWKLNFNSPDCLDYKDQ 346
            .::|.               .|......||...:.||.|.:..:|:
  Fly   492 QVNYNMGHSGYTASNFGLSPSPSFTGTVSAQAFSQNSLDYMSPQDK 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OTX1	NP_055377.1	Homeodomain	39..95	CDD:459649	54/59 (92%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..146		22/83 (27%)
		TF_Otx	178..274	CDD:427350	35/195 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..305		17/86 (20%)
oc	NP_001356934.1	Homeodomain	68..123	CDD:459649	52/54 (96%)