Protein Alignment CAH5 and CA8

DIOPT Version :10

• Sequence 1: NP_001097988.2
• Gene: CAH5 / 50102
• FlyBaseID: FBgn0040629
• Length: 302
• Species: Drosophila melanogaster
• Sequence 2: NP_001399060.1
• Gene: CA8 / 767
• HGNCID: 1382
• Length: 306
• Species: Homo sapiens
• Alignment Length: 283
• Identity: 78/283 - (27%)
• Similarity: 136/283 - (48%)
• Gaps: 50/283 - (17%)

  Fly    20 IEIPEAYLTAIRQDRADEQAAGEYNYDEQGDDWTGTC---QSGENQSPIDLIFEDSKIVAIPRLR 81
            :..||.     .:|..:|:...|:.| |:|.:| |..   .:||.||||:|...:::
Human    11 VAFPEK-----EEDEEEEEEGVEWGY-EEGVEW-GLVFPDANGEYQSPINLNSREAR-------- 60

  Fly    82 FNNYDQPLQTPLV-----------ITNNGHTANMVIPQTRGGQRPSINGSLLP--GNFEAQSVHF 133
               ||..|....:           :||:|||..:::.     .:..::|..||  ..||...|.|
Human    61 ---YDPSLLDVRLSPNYVVCRDCEVTNDGHTIQVILK-----SKSVLSGGPLPQGHEFELYEVRF 117

  Fly   134 HWGSREAKGSEHAINFQRYDVEMHIVHKN-TIYETMGEATMHPDGLAVLGVMFRAVDRQTSQHYG 197
            |||....:||||.:||:.:.:|:|::|.| |::.::.||...|.|:|:: .:|..:.:   :|.|
Human   118 HWGRENQRGSEHTVNFKAFPMELHLIHWNSTLFGSIDEAVGKPHGIAII-ALFVQIGK---EHVG 178

  Fly   198 LNKIFNQLPRIVQYNSNATITGRLTVGQLLGNIVTGEFFTYNGSLTTPDCAEAVTWTVFPDVLDY 262
            | |...::.:.:||...:..........||.:.:..:::.|.||||.|.|:|.|||.:|...|..
Human   179 L-KAVTEILQDIQYKGKSKTIPCFNPNTLLPDPLLRDYWVYEGSLTIPPCSEGVTWILFRYPLTI 242

  Fly   263 PRRQITKLWNLRDSRQ--RPLIN 283
            .:.|:   |.:...|:  .|:|:
Human   243 SQLQV---WRMESGRKVGMPVIS 262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAH5	NP_001097988.2	Carb_anhydrase	50..299	CDD:459707	70/253 (28%)
CA8	NP_001399060.1	alpha_CARP_VIII	35..305	CDD:239394	70/253 (28%)