Protein Alignment CAH5 and CA4

DIOPT Version :10

• Sequence 1: NP_001097988.2
• Gene: CAH5 / 50102
• FlyBaseID: FBgn0040629
• Length: 302
• Species: Drosophila melanogaster
• Sequence 2: XP_005257696.1
• Gene: CA4 / 762
• HGNCID: 1375
• Length: 336
• Species: Homo sapiens
• Alignment Length: 313
• Identity: 89/313 - (28%)
• Similarity: 135/313 - (43%)
• Gaps: 57/313 - (18%)

  Fly    27 LTAIRQDRADEQAAGEYNYDEQGDD----------WTGTCQSGENQSPIDLIFEDSKI-VAIPRL 80
            |.|:...|....|...:.|:.|.:.          |.|.||. :.||||:::...:|: ..:.|.
Human     7 LLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQK-DRQSPINIVTTKAKVDKKLGRF 70

  Fly    81 RFNNYDQPLQTPLVITNNGHTANMVIPQTRGGQRPSINGSLLPGNFEAQSVHFHWGSREAKGSEH 145
            .|:.||:. || ..:.||||:..|::.     .:.||:|..||..::|:.:|.||.....|||||
Human    71 FFSGYDKK-QT-WTVQNNGHSVMMLLE-----NKASISGGGLPAPYQAKQLHLHWSDLPYKGSEH 128

  Fly   146 AINFQRYDVEMHIVH---KNTIYETMGEATMHPDGLAVLGVM----------------------- 184
            :::.:.:.:||||||   |.| ...:.||....|.:|||..:
Human   129 SLDGEHFAMEMHIVHEKEKGT-SRNVKEAQDPEDEIAVLAFLVEIGRMNWPPPLAPCRLSQDPSL 192

  Fly   185 -FRAVDRQTSQHYGLNKIFNQLPRIVQYNSNATITGRLTVGQLLGNIVTGEFFTYNGSLTTPDCA 248
             |:|   .|..:.|...:...|..|.:...:.|:.....:..|........:|.|.||||||.|.
Human   193 PFQA---GTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCD 254

  Fly   249 EAVTWTVFPDVLDYPRRQI----TKLWNLRDSRQR-PLINNYRSIQDTNSRDV 296
            |.|.||||.:.:...|.||    .||:  .|..|. .:.:|.|.:|....|.|
Human   255 EKVVWTVFREPIQLHREQILAFSQKLY--YDKEQTVSMKDNVRPLQQLGQRTV 305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAH5	NP_001097988.2	Carb_anhydrase	50..299	CDD:459707	83/290 (29%)
CA4	XP_005257696.1	alpha_CA_IV_XV_like	48..307	CDD:239391	79/272 (29%)