Protein Alignment CAH5 and CA3

DIOPT Version :10

• Sequence 1: NP_001097988.2
• Gene: CAH5 / 50102
• FlyBaseID: FBgn0040629
• Length: 302
• Species: Drosophila melanogaster
• Sequence 2: NP_005172.1
• Gene: CA3 / 761
• HGNCID: 1374
• Length: 260
• Species: Homo sapiens
• Alignment Length: 275
• Identity: 83/275 - (30%)
• Similarity: 123/275 - (44%)
• Gaps: 39/275 - (14%)

  Fly    40 AGEYNYDEQG--DDWTGTCQS--GENQSPIDLIFEDSKIVAIPRLRFNNYDQPLQ---------T 91
            |.|:.|....  |.|.....:  ||||||::|..:|.:           :|..||         :
Human     2 AKEWGYASHNGPDHWHELFPNAKGENQSPVELHTKDIR-----------HDPSLQPWSVSYDGGS 55

  Fly    92 PLVITNNGHTANMVIPQTRGGQRPSINGSLLPGNFEAQSVHFHWGSREAKGSEHAINFQRYDVEM 156
            ...|.|||.|..:|...|.  .|..:.|..|||.:..:..|.||||.:..||||.::..:|..|:
Human    56 AKTILNNGKTCRVVFDDTY--DRSMLRGGPLPGPYRLRQFHLHWGSSDDHGSEHTVDGVKYAAEL 118

  Fly   157 HIVHKNTIYETMGEATMHPDGLAVLGVMFRAVDRQTSQHYGLNKIF-NQLPRIVQYNSNATITGR 220
            |:||.|..|.|..||....||:||:|:..:     .....|..:|| :.|.:|......|..| :
Human   119 HLVHWNPKYNTFKEALKQRDGIAVIGIFLK-----IGHENGEFQIFLDALDKIKTKGKEAPFT-K 177

  Fly   221 LTVGQLLGNIVTGEFFTYNGSLTTPDCAEAVTWTVFPDVLDYPRRQITKLWNLRDSRQR----PL 281
            .....|..  ...:::||.||.|||.|.|.:.|.:..:.:.....|:.||.:|..|.:.    ||
Human   178 FDPSCLFP--ACRDYWTYQGSFTTPPCEECIVWLLLKEPMTVSSDQMAKLRSLLSSAENEPPVPL 240

  Fly   282 INNYRSIQDTNSRDV 296
            ::|:|..|..|:|.|
Human   241 VSNWRPPQPINNRVV 255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAH5	NP_001097988.2	Carb_anhydrase	50..299	CDD:459707	80/263 (30%)
CA3	NP_005172.1	alpha_CA_I_II_III_XIII	1..259	CDD:239393	83/275 (30%)
		Involved in proton transfer. /evidence=ECO:0000269|PubMed:17427958	64..67		1/2 (50%)