Protein Alignment CAH5 and CA1

DIOPT Version :10

• Sequence 1: NP_001097988.2
• Gene: CAH5 / 50102
• FlyBaseID: FBgn0040629
• Length: 302
• Species: Drosophila melanogaster
• Sequence 2: NP_001729.1
• Gene: CA1 / 759
• HGNCID: 1368
• Length: 261
• Species: Homo sapiens
• Alignment Length: 275
• Identity: 74/275 - (26%)
• Similarity: 122/275 - (44%)
• Gaps: 36/275 - (13%)

  Fly    39 AAGEYNYDEQG--DDWTG--TCQSGENQSPIDLIFEDSKIVAIPRLRFNNYDQPLQTPLVITNNG 99
            |:.::.||::.  :.|:.  ...:|.||||:|:...::|           :|..|: |:.::.|.
Human     2 ASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETK-----------HDTSLK-PISVSYNP 54

  Fly   100 HTANMVIPQTR--------GGQRPSINGSLLPGNFEAQSVHFHWGSREAKGSEHAINFQRYDVEM 156
            .||..:|....        ...|..:.|.....::.....||||||....||||.::..:|..|:
Human    55 ATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAEL 119

  Fly   157 HIVHKNTI-YETMGEATMHPDGLAVLGVMFRAVDRQTSQHYGLNKIFNQLPRIVQYNSNATITGR 220
            |:.|.|:. |.::.||....|||||:||:.:..:....    |.|:.:.|..|......|..| .
Human   120 HVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPK----LQKVLDALQAIKTKGKRAPFT-N 179

  Fly   221 LTVGQLLGNIVTGEFFTYNGSLTTPDCAEAVTWTVFPDVLDYPRRQITK----LWNLRDSRQRPL 281
            .....||.:.:  :|:||.||||.|...|:|||.:..:.:.....|:.:    |.|:......|:
Human   180 FDPSTLLPSSL--DFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPM 242

  Fly   282 INNYRSIQDTNSRDV 296
            .:|.|..|....|.|
Human   243 QHNNRPTQPLKGRTV 257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAH5	NP_001097988.2	Carb_anhydrase	50..299	CDD:459707	71/262 (27%)
CA1	NP_001729.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		7/28 (25%)
		alpha_CA	2..261	CDD:469577	74/275 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	241..261		6/17 (35%)