Protein Alignment CAH5 and CA14

DIOPT Version :10

• Sequence 1: NP_001097988.2
• Gene: CAH5 / 50102
• FlyBaseID: FBgn0040629
• Length: 302
• Species: Drosophila melanogaster
• Sequence 2: NP_036245.1
• Gene: CA14 / 23632
• HGNCID: 1372
• Length: 337
• Species: Homo sapiens
• Alignment Length: 288
• Identity: 95/288 - (32%)
• Similarity: 145/288 - (50%)
• Gaps: 47/288 - (16%)

  Fly    39 AAGEYNYDEQG----DDWTGTC-QSGEN-QSPIDL-----IFEDSKIVAIPRLRFNNYDQPLQTP 92
            |.|..::..:|    |.|..:. :.|.| |||||:     .|:..    :|.|:.:.||||...|
Human    16 ADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPD----LPALQPHGYDQPGTEP 76

  Fly    93 LVITNNGHTANMVIPQT--RGGQRPSINGSLLPGNFEAQSVHFHWGSREAK-GSEHAINFQRYDV 154
            |.:.|||||..:.:|.|  .||         ||..:.|..:|.|||.:.:. ||||.||.:....
Human    77 LDLHNNGHTVQLSLPSTLYLGG---------LPRKYVAAQLHLHWGQKGSPGGSEHQINSEATFA 132

  Fly   155 EMHIVHKNT-IYETMGEATMHPDGLAVLGVMFRAVDRQTSQHYGLNKIFNQLPRIVQYNSNATIT 218
            |:||||.:: .|:::.||...|.||||||::   ::...:::.....|.:.|.. |::....|..
Human   133 ELHIVHYDSDSYDSLSEAAERPQGLAVLGIL---IEVGETKNIAYEHILSHLHE-VRHKDQKTSV 193

  Fly   219 GRLTVGQLLGNIVTGEFFTYNGSLTTPDCAEAVTWTVFPDVLDYPRRQIT---------KLWNLR 274
            ....:.:||...: |::|.||||||||.|.::|.||||     |.|.||:         .|::..
Human   194 PPFNLRELLPKQL-GQYFRYNGSLTTPPCYQSVLWTVF-----YRRSQISMEQLEKLQGTLFSTE 252

  Fly   275 DSRQRPLINNYRSIQDTNSRDVYYRTIQ 302
            :...:.|:.|||::|..|.|.|:...||
Human   253 EEPSKLLVQNYRALQPLNQRMVFASFIQ 280

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAH5	NP_001097988.2	Carb_anhydrase	50..299	CDD:459707	90/268 (34%)
CA14	NP_036245.1	alpha_CA_XII_XIV	29..278	CDD:239400	90/271 (33%)