DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13643 and Y56A3A.6

DIOPT Version :9

Sequence 1:	NP_001262937.1	Gene:	CG13643 / 50074	FlyBaseID:	FBgn0040601	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_499539.1	Gene:	Y56A3A.6 / 176618	WormBaseID:	WBGene00013227	Length:	798	Species:	Caenorhabditis elegans

Alignment Length:	747	Identity:	148/747 - (19%)
Similarity:	234/747 - (31%)	Gaps:	276/747 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 LQRAETGDIRRS-------KENHNNNNINNNRGADQKPRHRHNYAQTGGSSSSSSSPKLEITQST 217
            ::.|:.|.||..       ||:.....:.:|:.....|:       ||.:||.|||
Worm   212 MKLADGGSIREERMKAEVLKEHERLKMLLDNQITSDLPK-------TGSASSQSSS--------- 260

  Fly   218 KRPISTYYTPTTLGSTTTSTTSTTTTTERSYYNNNYNNNYSNNDDSKQDLDDIFKGSHSSHFFSN 282
                                         |..|||:||   ||::.|:.|.  .|.....:|:|
Worm   261 -----------------------------SSGNNNHNN---NNNNVKKQLP--LKIPQYGNFYS- 290

  Fly   283 RHGGREYDEEPSRPKPNDFSDYQRKTTRVTPTRG----VQRPTS----GSSSPIPSSTAAPSTTK 339
                     :||:|.       |.::..|.|...    |.:.||    ...||:|:.......|.
Worm   291 ---------QPSQPA-------QNRSPPVAPQAAPGGTVYKRTSREKLSPKSPVPNGNIISPKTD 339

  Fly   340 SLKKITLHATFNTDFLDSSSHTKSPSYSAVTTPRPSSSITSR------FSFGSNDFSTQERIQPT 398
            ..:.|.         :.|:|....||.:.|...|....:..:      .....|..:.:.:..|.
Worm   340 ENRNIV---------VTSASPKNPPSQNTVAVDRLRREVEEQRQREKEVKQYRNPRALESQASPR 395

  Fly   399 TYNPNNGAYRFKTTSPPASS------------TKVTGKGVQDFEKR----------SKPTSAAVR 441
            ..:|......:|....|...            .|.....:.|:.|.          |.||:..||
Worm   396 KSSPGPRMVEYKAMKSPGLEPDGVYEEIAPPIPKNPPPKLSDYRKEQQTVVAPRMPSVPTNGYVR 460

  Fly   442 KQKLGPQESNF------INQNEFV--DLSKSTKL--QQPQPFQVAQTKP--------------NQ 482
            .|..|.:.:..      ::...:.  :.|.|.||  :.|:|.::..:.|              .|
Worm   461 LQMNGKKPAPVTPHPVKLSPTPYTGPEYSSSPKLLRKTPEPAKIYSSVPVKEEKKVYEKPQAHPQ 525

  Fly   483 LEP-------------HYQRHKPQVTRVGGQEPAPFSAPSSKPRSFTSRGSITYKATTERYVDQE 534
            :.|             :|||.||...:     |.|.|:|            :..:|.:   |||.
Worm   526 IAPPMVRAASVDQNGNNYQRSKPVEVK-----PRPVSSP------------LMIRAAS---VDQN 570

  Fly   535 LYYPTTSSTTRAKEAYTPTTFRPTTYKK-----PYEQSYQSQQTHRPTQAATKKAA---HSVTS- 590
               |.|:|.:..:::....|..|.:|:|     |..|......|..|:....:|.:   ..|||
Worm   571 ---PMTASPSVIRKSQVTATQSPVSYRKIPPTSPTPQRRPLNNTEVPSPVTYRKISAPVQKVTSP 632

  Fly   591 APP------TTTNPHANVDEDDGQYHPELYENDFPRNRIRFLRNRSTSSTTSTTSA--------- 640
            |||      |...|.||                 .|:::..|...|:.:|.:.|||
Worm   633 APPAARSVSTDQPPPAN-----------------RRSQVGILSATSSKATVTVTSATSPPYPKGS 680

  Fly   641 --PVVSSRQPHGFQQAHHHLKSQQQSVYQKERERERERERESDLSDEDELFKTAQSLNFGAASIN 703
              |.|.|.:|...|||.           ...|....:.:...|:||   :.|..
Worm   681 VGPTVISIKPAPVQQAP-----------MAPRAAPTKVDTSFDISD---VLKGP----------- 720

  Fly   704 KLRADIYKAEKTSQQYNSQYSPQLASSPQASSSSSSSTSTTSTTTSTTTTTTRRPPTTVRTTTTT 768
            |||.....|||:.....     ::..|.:||.:..|||.....           ||..:
Worm   721 KLRKVGMPAEKSGISLG-----KVVESVEASGNRPSSTPPPPP-----------PPPPL------ 763

  Fly   769 FTTSAPPVETKKSVKSKKEQQQLEKKDRPAGK 800
              .:|||     ..|:...:..|..:.|.||:
Worm   764 --AAAPP-----QPKNPDLRDSLMNEIREAGR 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13643	NP_001262937.1	CBM_14	63..126	CDD:279884
Y56A3A.6	NP_499539.1	PHA03247	<448..704	CDD:223021	66/306 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22933
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100