DRSC/TRiP Functional Genomics Resources

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Protein Alignment mask and ANKRD44

DIOPT Version :9

Sequence 1:NP_001247280.1 Gene:mask / 50070 FlyBaseID:FBgn0043884 Length:4010 Species:Drosophila melanogaster
Sequence 2:NP_001354424.1 Gene:ANKRD44 / 91526 HGNCID:25259 Length:1074 Species:Homo sapiens


Alignment Length:932 Identity:215/932 - (23%)
Similarity:311/932 - (33%) Gaps:324/932 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   472 DEEEIDVLQDNDADDEEIDDEDEEEDAP-EVSSFLLDANNKRSSNISALLEAAANEK-----APV 530
            |.|||.:|...   .|:::..|.|:..| .|::||.||   ....:..|..|..|.|     .|:
Human    20 DPEEIRMLIHK---TEDVNTLDSEKRTPLHVAAFLGDA---EIIELLILSGARVNAKDNMWLTPL 78

  Fly   531 LRHATHAIDETKQALTKMRCASSPRDKNGFSRSLVAACTDNDVNTVKRLLCK-------GNVNLN 588
            .|......:|..|.|.|.....:.||||..:...|||..       |.:.|.       .:||::
Human    79 HRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAAN-------KAVKCAEVIIPLLSSVNVS 136

  Fly   589 DAAASTDDGESLLSMACSAGYYELAQVLLAMSAAQVEDKGQKDSTPLMEAASAGHLDIVKLLLNH 653
            |..     |.:.|..|...|:.|:..:||| ..|.:....:||...|..||..||||:|.||:||
Human   137 DRG-----GRTALHHAALNGHVEMVNLLLA-KGANINAFDKKDRRALHWAAYMGHLDVVALLINH 195

  Fly   654 NADVNA---------HCAT------------------------GNTPLMFACAGGQVDVVKVLLK 685
            .|:|..         |.|.                        |||.|..||..||..||..|:.
Human   196 GAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELID 260

  Fly   686 HGANVEEQNENGHTPLMEAASAGHVEVA-KVLLEHGAGINTHSNEFK------------------ 731
            :||||.:.|.||.|||..||::.|..:. ::|:.:||.:|..|.:.|                  
Human   261 YGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTL 325

  Fly   732 --------------ESALTLACYKGHLDMVRFLLQAGADQE----HKTDEMHTALMEASMD---- 774
                          .:.|.:|...||..::..|:.:|||..    |....:|.|.:.|..|    
Human   326 IQNGGEIDCVDKDGNTPLHVAARYGHELLINTLITSGADTAKCGIHSMFPLHLAALNAHSDCCRK 390

  Fly   775 -------------------------------------------GHVEVARLLLDSGAQVNMPTDS 796
                                                       |:||..:||..|||..:.....
Human   391 LLSSGQKYSIVSLFSNEHVLSAGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKC 455

  Fly   797 FESPLTLAACGGHVELATLLIERGANIEEVND--------------------------------- 828
            ..:||..||...|......|:..|||:.|.:|                                 
Human   456 GRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELER 520

  Fly   829 ----------------------------EGYTPLMEAAREGHEEMVALLLSK------GANINAT 859
                                        |||..:..||..||.:.:.|||.:      .::..||
Human   521 ARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGAT 585

  Fly   860 ----------------------------TEETQETALTLACCGGFMEVAAFLIKEGAN------- 889
                                        .:|...|||.||...|..|....||.:||:       
Human   586 KSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINQGASIFVKDNV 650

  Fly   890 ---------------------LELG------------ASTPLMEASQEGHTDLVSFLLKKKANVH 921
                                 ||:.            ..||||.|...||.|.||.||:|:|||.
Human   651 TKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVD 715

  Fly   922 AETQTGDTALTHACENGHTDAAGVLLSYGAELEHESEGGRTPLMKACRAGHLCTVKFLIQKGANV 986
            .....|.|||......||.:...:||.....:..:...|||||..|...||...:..|:|...:.
Human   716 TVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSE 780

  Fly   987 NKQTTSND--HTALSLACAGGHQSVVELLLKNN------ADPFHKLK------------------ 1025
            ......::  :|.|..||..|:::.:|:||:..      .:||..|.                  
Human   781 EDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAI 845

  Fly  1026 DNSTMLIEASKG----------GHTRVVELLFRY-PNISPTENAASANVTQAAPTSNQPGPNQMR 1079
            |:|.:.....||          .|...::||.|: ..::..:|:....:..|| .:.|.|...:.
Human   846 DSSIVSCRDDKGRTPLHAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAA-ENGQAGAVDIL 909

  Fly  1080 QKIMKQQLQHQLQQLNAPPGLH 1101
            ....:..|..:.:.||.|  ||
Human   910 VNSAQADLTVKDKDLNTP--LH 929

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
maskNP_001247280.1 ANK 555..684 CDD:238125 49/168 (29%)
Ank_2 564..659 CDD:289560 33/101 (33%)
ANK repeat 596..628 CDD:293786 9/31 (29%)
ANK 633..751 CDD:238125 50/183 (27%)
ANK repeat 633..661 CDD:293786 14/36 (39%)
Ank_2 635..724 CDD:289560 43/122 (35%)
ANK repeat 663..694 CDD:293786 15/54 (28%)
ANK repeat 696..724 CDD:293786 11/28 (39%)
Ank_5 716..771 CDD:290568 17/90 (19%)
ANK 726..850 CDD:238125 42/267 (16%)
ANK repeat 730..760 CDD:293786 9/65 (14%)
ANK repeat 765..794 CDD:293786 12/75 (16%)
Ank_2 768..859 CDD:289560 31/204 (15%)
ANK repeat 796..827 CDD:293786 10/30 (33%)
ANK repeat 829..858 CDD:293786 10/34 (29%)
ANK repeat 862..894 CDD:293786 14/71 (20%)
ANK 896..1014 CDD:238125 40/119 (34%)
ANK repeat 896..923 CDD:293786 16/26 (62%)
Ank_2 898..989 CDD:289560 32/90 (36%)
ANK repeat 927..957 CDD:293786 8/29 (28%)
ANK repeat 959..991 CDD:293786 10/31 (32%)
ANK 989..>1049 CDD:238125 18/95 (19%)
ANK repeat 993..1023 CDD:293786 10/37 (27%)
Ank_4 995..1046 CDD:290365 16/84 (19%)
ANK 2321..2349 CDD:197603
ANK repeat 2323..2352 CDD:293786
Ank_2 2326..2419 CDD:289560
ANK 2350..2477 CDD:238125
ANK repeat 2354..2386 CDD:293786
ANK repeat 2390..2419 CDD:293786
Ank_2 2393..2486 CDD:289560
ANK repeat 2421..2452 CDD:293786
ANK repeat 2456..2486 CDD:293786
ANK 2457..2579 CDD:238125
Ank_2 2461..2552 CDD:289560
ANK repeat 2492..2521 CDD:293786
ANK 2519..2645 CDD:238125
ANK repeat 2523..2589 CDD:293786
Ank_2 2528..2622 CDD:289560
ANK repeat 2560..2587 CDD:293786
ANK repeat 2591..2622 CDD:293786
KH-I 3049..3110 CDD:238053
ANKRD44NP_001354424.1 ANK 1 7..36 6/18 (33%)
ANK 2 40..69 9/31 (29%)
ANK 3 73..102 6/28 (21%)
ANK 4 106..135 7/35 (20%)
ANK 5 139..168 9/34 (26%)
ANK 6 172..201 16/28 (57%)
ANK 7 205..234 2/28 (7%)
ANK 8 238..267 15/28 (54%)
ANK 9 271..301 11/29 (38%)
ANK 10 305..334 1/28 (4%)
ANK 11 338..367 8/28 (29%)
ANK 13 422..451 8/28 (29%)
ANK 14 455..484 9/28 (32%)
ANK 15 488..516 0/27 (0%)
ANK 16 549..579 10/29 (34%)
ANK 17 584..613 2/28 (7%)
ANK 18 617..646 11/28 (39%)
ANK 19 651..680 2/28 (7%)
ANK 20 687..716 16/28 (57%)
ANK 21 720..749 8/28 (29%)
ANK 22 753..782 10/28 (36%)
ANK 23 789..818 8/28 (29%)
ANK 24 821..850 5/28 (18%)
ANK 25 856..885 6/28 (21%)
ANK 26 889..919 5/30 (17%)
ANK 27 923..952 5/9 (56%)
ANK 28 959..988
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1115202at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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