DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mask and HOS4

DIOPT Version :9

Sequence 1:	NP_001247280.1	Gene:	mask / 50070	FlyBaseID:	FBgn0043884	Length:	4010	Species:	Drosophila melanogaster
Sequence 2:	NP_012154.1	Gene:	HOS4 / 854694	SGDID:	S000001374	Length:	1083	Species:	Saccharomyces cerevisiae

Alignment Length:	1078	Identity:	221/1078 - (20%)
Similarity:	370/1078 - (34%)	Gaps:	326/1078 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 PAPSSSSSSSSSSKKT-RAAVAALKRQVALQQQQPVTGNAPNMTSKDSAHLKF--------ATTT 284
            |....|.||..|:..| |..:..:.:|...:::.....:....|..:....||        :.||
Yeast     9 PLKKRSLSSYLSNVSTRREELEKISKQETSEEEDTAGKHEQRETLSEEVSDKFPENVASFRSQTT 73

  Fly   285 LLMGAAAAAADSNAGAALGGSGAGGSGSSSSVGAVGGARMALNPAVDMANAAVLLKQKLKDAAAA 349
                :...|..:|..|......|..:.:||..|.|.|                        .:..
Yeast    74 ----SVHQATQNNLNAKESEDLAHKNDASSHEGEVNG------------------------DSRP 110

  Fly   350 ASASASNRSATSSMSSTASSLSSSAGIVNAISSALQNIITPDTDTDTEFYPQPVTTD-----LSE 409
            .....:|...:.::.:..||.|||..:.|.   .:||             .||.:.|     |.|
Yeast   111 DDVPETNEKISQAIRAKISSSSSSPNVRNV---DIQN-------------HQPFSRDQLRAMLKE 159

  Fly   410 SEEESVSEILLAFLCLRPDLLDDIPESDPDSCPHEGEVREDEDETEEESEDSDESEGEEEEEDEE 474
            .:.::|               ||..|       .||....:|::..:|..:.:.:|.|..|:|.|
Yeast   160 PKRKTV---------------DDFIE-------EEGLGAVEEEDLSDEVLEKNTTEPENVEKDIE 202

  Fly   475 EIDVLQDNDADDEEIDD----------------EDEEEDAPEVSSFLLDANNKRSSNISALLEAA 523
            ..|  .|.|.||...||                ..::.||...|.|    ||:..|.:|. ::.:
Yeast   203 YSD--SDKDTDDVGSDDPTAPNSPIKLGRRKLVRGDQLDATTSSMF----NNESDSELSD-IDDS 260

  Fly   524 AN--EKAPVLRHATHAIDETKQALTKMRCASSPRDKNG-FSRSLVAACTDNDVNTVKRLLCKGNV 585
            .|  ..:.:.|..:..:.||...|:.|..:.:...|.| .|||
Yeast   261 KNIALSSSLFRGGSSPVKETNNNLSNMNSSPAQNPKRGSVSRS---------------------- 303

  Fly   586 NLNDAAASTDDGESLLSMACSAGYYELAQVLLAMSAAQVEDKG-QKDSTPLMEAASAGHLDIVKL 649
              ||:..|:.                     :|:|....:.|| .:||
Yeast   304 --NDSNKSSH---------------------IAVSKRPKQKKGIYRDS----------------- 328

  Fly   650 LLNHNADVNAHCATGNTPLMFACAGGQVDVVKVLLKHGA-NVEEQNENGHTPLMEAASAGHVEVA 713
                         .|.|.|..||..|:.||||.:::.|. ::.:|:..|:|.|.|||..||:|:.
Yeast   329 -------------GGRTRLQIACDKGKYDVVKKMIEEGGYDINDQDNAGNTALHEAALQGHIEIV 380

  Fly   714 KVLLEHGAGINTHSNE-FKESALTLACYKGHLDMVRFLLQAGADQEHKTDEMHTALMEASMDGHV 777
            ::|:|:||.:|..|.| |.::.|..|...||||:|::||:.|||...:..:..||.  .|:|...
Yeast   381 ELLIENGADVNIKSIEMFGDTPLIDASANGHLDVVKYLLKNGADPTIRNAKGLTAF--ESVDDES 443

  Fly   778 EVARLLLDSGAQVNMPTDSFESPLTLAACGGHVELATLLIERGANIEEVNDEGYTPLMEAAREGH 842
            |.               |..|....|......:.:|.......|.|.  ||:
Yeast   444 EF---------------DDEEDQKILREIKKRLSIAAKKWTNRAGIH--NDK------------- 478

  Fly   843 EEMVALLLSKGANINATTEETQETALTLACCGGFMEVAAFLIKEGANLELGASTPLM------EA 901
                    ||..| ||.|                ::...|.....|..|..|.:|.|      :|
Yeast   479 --------SKNGN-NAHT----------------IDQPPFDNTTKAKNEKAADSPSMASNIDEKA 518

  Fly   902 SQEGH--TDLVSFLLKKKANVHAETQTGDTALTHACENGHTDAAGVLLSYGAELEHESEGGRTPL 964
            .:|..  ||:.|             :.|...|..|.:.||....|..:..|.:::..|      .
Yeast   519 PEEEFYWTDVTS-------------RAGKEKLFKASKEGHLPYVGTYVENGGKIDLRS------F 564

  Fly   965 MKACRAGHLCTVKFLIQKGANVNKQTTSNDHTALSLACAGGHQSVVELLLKNNADPFHKLKDNST 1029
            .::.:.||.......:..|..||:.:..|..:||.:|...||...|:|||:..|||..:.|...|
Yeast   565 FESVKCGHEDITSIFLAFGFPVNQTSRDNKTSALMVAVGRGHLGTVKLLLEAGADPTKRDKKGRT 629

  Fly  1030 MLIEASKG--GHTRVVELLFRYPNISPTENAASANVTQAAPTSNQPGPN--------QMRQKIMK 1084
            .|..|...  |.|...|       |...|||.:..:.:.:..:|....:        :..:|..|
Yeast   630 ALYYAKNSIMGITNSEE-------IQLIENAINNYLKKHSEDNNDDDDDDDNNNETYKHEKKREK 687

  Fly  1085 QQLQHQLQQLNAPPGLHELSEAARA--------SNQQHFHQQQFSSAGNGSSNIVAMGTGDFLD- 1140
            .|......:.:|.|.:.:..:..|.        :|.:...:...|.:.....:...:||...||
Yeast   688 TQSPILASRRSATPRIEDEEDDTRMLNLADDDFNNDRDVKESTTSDSRKRLDDNENVGTQYSLDW 752

  Fly  1141 --------AGELQLTATAGMSAGAGTSTTGSETGMEEYG-------EVGGIDLTTLGAQQ----Q 1186
                    ..|.:|.:.:.:|             ||.:.       |:..|...|...::    :
Yeast   753 KKRKTNALQDEEKLKSISPLS-------------MEPHSPKKAKSVEISKIHEETAAEREARLKE 804

  Fly  1187 EGLIAKSRLFHLQQQQQQQQQQQQQQQQQQQQQQQQQQ 1224
            |....|.||...::::|:..|:..:.::::.::|::|:
Yeast   805 EEEYRKKRLEKKRKKEQELLQKLAEDEKKRIEEQEKQK 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mask	NP_001247280.1	ANK	555..684	CDD:238125	24/130 (18%)
		Ank_2	564..659	CDD:289560	9/95 (9%)
		ANK repeat	596..628	CDD:293786	2/31 (6%)
		ANK	633..751	CDD:238125	36/119 (30%)
		ANK repeat	633..661	CDD:293786	0/27 (0%)
		Ank_2	635..724	CDD:289560	25/89 (28%)
		ANK repeat	663..694	CDD:293786	11/31 (35%)
		ANK repeat	696..724	CDD:293786	13/27 (48%)
		Ank_5	716..771	CDD:290568	22/55 (40%)
		ANK	726..850	CDD:238125	28/124 (23%)
		ANK repeat	730..760	CDD:293786	13/29 (45%)
		ANK repeat	765..794	CDD:293786	5/28 (18%)
		Ank_2	768..859	CDD:289560	15/90 (17%)
		ANK repeat	796..827	CDD:293786	5/30 (17%)
		ANK repeat	829..858	CDD:293786	3/28 (11%)
		ANK repeat	862..894	CDD:293786	3/31 (10%)
		ANK	896..1014	CDD:238125	28/125 (22%)
		ANK repeat	896..923	CDD:293786	7/34 (21%)
		Ank_2	898..989	CDD:289560	19/98 (19%)
		ANK repeat	927..957	CDD:293786	7/29 (24%)
		ANK repeat	959..991	CDD:293786	5/31 (16%)
		ANK	989..>1049	CDD:238125	20/61 (33%)
		ANK repeat	993..1023	CDD:293786	13/29 (45%)
		Ank_4	995..1046	CDD:290365	19/52 (37%)
		ANK	2321..2349	CDD:197603
		ANK repeat	2323..2352	CDD:293786
		Ank_2	2326..2419	CDD:289560
		ANK	2350..2477	CDD:238125
		ANK repeat	2354..2386	CDD:293786
		ANK repeat	2390..2419	CDD:293786
		Ank_2	2393..2486	CDD:289560
		ANK repeat	2421..2452	CDD:293786
		ANK repeat	2456..2486	CDD:293786
		ANK	2457..2579	CDD:238125
		Ank_2	2461..2552	CDD:289560
		ANK repeat	2492..2521	CDD:293786
		ANK	2519..2645	CDD:238125
		ANK repeat	2523..2589	CDD:293786
		Ank_2	2528..2622	CDD:289560
		ANK repeat	2560..2587	CDD:293786
		ANK repeat	2591..2622	CDD:293786
		KH-I	3049..3110	CDD:238053
HOS4	NP_012154.1	ANK repeat	330..361	CDD:293786	11/30 (37%)
		Ank_2	334..429	CDD:403870	39/94 (41%)
		ANK repeat	363..396	CDD:293786	15/32 (47%)
		ANK repeat	398..429	CDD:293786	13/30 (43%)
		Ank_2	537..624	CDD:403870	25/92 (27%)
		ANK repeat	592..624	CDD:293786	13/31 (42%)
		Ank_2	598..>656	CDD:403870	22/64 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto99127
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2152
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940