DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mask and PLA2G6

DIOPT Version :9

Sequence 1:	NP_001247280.1	Gene:	mask / 50070	FlyBaseID:	FBgn0043884	Length:	4010	Species:	Drosophila melanogaster
Sequence 2:	NP_001336793.1	Gene:	PLA2G6 / 8398	HGNCID:	9039	Length:	806	Species:	Homo sapiens

Alignment Length:	702	Identity:	153/702 - (21%)
Similarity:	255/702 - (36%)	Gaps:	163/702 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   526 EKAP------VLRHATHAIDETKQALTKMRCASSPRDKNGFSRSLVAACTDNDVNTVKRLLCKGN 584
            |.:|      ||:|.|..| ....:.:....|.....:..|..|.:.:|.:
Human    96 ESSPQVLHTEVLQHLTDLI-RNHPSWSVAHLAVELGIRECFHHSRIISCAN-------------- 145

  Fly   585 VNLNDAAASTDDGESLLSMACSAGYYELAQVLLAMSAAQVEDKGQKDSTPLMEAASAGHLDIVKL 649
                  .|..::|.:.|.:||..|..|:...|:.....|::....|..|....|....:..:::|
Human   146 ------CAENEEGCTPLHLACRKGDGEILVELVQYCHTQMDVTDYKGETVFHYAVQGDNSQVLQL 204

  Fly   650 L-LNHNADVNAHCATGNTPLMFACAGGQVDVVKVLLKHGANVEEQNENGHTPLMEAASAGHVEVA 713
            | .|..|.:|.....|.|||..||..|:.::|:|||...|.......||: |:..|........|
Human   205 LGRNAVAGLNQVNNQGLTPLHLACQLGKQEMVRVLLLCNARCNIMGPNGY-PIHSAMKFSQKGCA 268

  Fly   714 KVLLEHGAGINTHSNEFKESALTLACYKGHLDMVRFLLQAGADQEHKTDEMHTALMEASMDGHVE 778
            ::::...:. ..||.:.:..|..|...| :.:|.|.||:.|.:....:...:|||..|.|....:
Human   269 EMIISMDSS-QIHSKDPRYGASPLHWAK-NAEMARMLLKRGCNVNSTSSAGNTALHVAVMRNRFD 331

  Fly   779 VARLLLDSGAQVNMPTDSFESPLTLAACGGHVELATLLIERGANIEEVNDEGYTPLMEAAREG-- 841
            .|.:||..||..:...:...:||.||....:||:...||..||.::..||.|.||...|::.|
Human   332 CAIVLLTHGANADARGEHGNTPLHLAMSKDNVEMIKALIVFGAEVDTPNDFGETPTFLASKIGRL 396

  Fly   842 --HEEMVALLLSKGA--------NINA-----------TTEETQETALTLACCGGFMEVAAFLIK 885
              .:.::.||.:.||        .:.|           :.|..|...::|
Human   397 VTRKAILTLLRTVGAEYCFPPIHGVPAEQGSAAPHHPFSLERAQPPPISL--------------- 446

  Fly   886 EGANLELGASTPLMEASQEGHTDLVSFLLKKKANVHAETQTGDTALTHACENGHTDAAGVLLSYG 950
              .||||   ..||..|:....   :|:|   .::..|.:|.|..|   |.:|
Human   447 --NNLEL---QDLMHISRARKP---AFIL---GSMRDEKRTHDHLL---CLDG------------ 485

  Fly   951 AELEHESEGGRTPLMKACRAGHLCTVKFLIQKGANVNKQTTSNDHTALSLACAGGHQSVVELLLK 1015
                    ||...|:       :..:...|:|.:.|   .|.:....::....||..::..|..|
Human   486 --------GGVKGLI-------IIQLLIAIEKASGV---ATKDLFDWVAGTSTGGILALAILHSK 532

  Fly  1016 NNA---DPFHKLKD---------NSTMLIEASK---GGHTRVVELLFRYPNISPTENAASANVTQ 1065
            :.|   ..:.::||         .|..|.|..|   |.||::.::  |.|.:..|...:.....:
Human   533 SMAYMRGMYFRMKDEVFRGSRPYESGPLEEFLKREFGEHTKMTDV--RKPKVMLTGTLSDRQPAE 595

  Fly  1066 AAPTSNQPGPNQMRQKIMKQQLQHQLQQLNAPPGLHELSEAARASNQQHFHQQQFSSAGNGSSNI 1130
            .....|...|..:|:....|.:..:      ||        |:.|:|..:.    ::..:|::..
Human   596 LHLFRNYDAPETVREPRFNQNVNLR------PP--------AQPSDQLVWR----AARSSGAAPT 642

  Fly  1131 VAMGTGDFLDAGELQLTATAGMSAGAGTSTTGSETGMEEYGEVGGIDLTTLG 1182
            .....|.|||.|.|           |...|..:.|.:.||.:    ||...|
Human   643 YFRPNGRFLDGGLL-----------ANNPTLDAMTEIHEYNQ----DLIRKG 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mask	NP_001247280.1	ANK	555..684	CDD:238125	29/129 (22%)
		Ank_2	564..659	CDD:289560	17/95 (18%)
		ANK repeat	596..628	CDD:293786	8/31 (26%)
		ANK	633..751	CDD:238125	31/118 (26%)
		ANK repeat	633..661	CDD:293786	7/28 (25%)
		Ank_2	635..724	CDD:289560	23/89 (26%)
		ANK repeat	663..694	CDD:293786	12/30 (40%)
		ANK repeat	696..724	CDD:293786	5/27 (19%)
		Ank_5	716..771	CDD:290568	13/54 (24%)
		ANK	726..850	CDD:238125	38/127 (30%)
		ANK repeat	730..760	CDD:293786	8/29 (28%)
		ANK repeat	765..794	CDD:293786	10/28 (36%)
		Ank_2	768..859	CDD:289560	30/113 (27%)
		ANK repeat	796..827	CDD:293786	10/30 (33%)
		ANK repeat	829..858	CDD:293786	9/40 (23%)
		ANK repeat	862..894	CDD:293786	6/31 (19%)
		ANK	896..1014	CDD:238125	21/117 (18%)
		ANK repeat	896..923	CDD:293786	5/26 (19%)
		Ank_2	898..989	CDD:289560	17/90 (19%)
		ANK repeat	927..957	CDD:293786	4/29 (14%)
		ANK repeat	959..991	CDD:293786	6/31 (19%)
		ANK	989..>1049	CDD:238125	15/74 (20%)
		ANK repeat	993..1023	CDD:293786	5/32 (16%)
		Ank_4	995..1046	CDD:290365	14/65 (22%)
		ANK	2321..2349	CDD:197603
		ANK repeat	2323..2352	CDD:293786
		Ank_2	2326..2419	CDD:289560
		ANK	2350..2477	CDD:238125
		ANK repeat	2354..2386	CDD:293786
		ANK repeat	2390..2419	CDD:293786
		Ank_2	2393..2486	CDD:289560
		ANK repeat	2421..2452	CDD:293786
		ANK repeat	2456..2486	CDD:293786
		ANK	2457..2579	CDD:238125
		Ank_2	2461..2552	CDD:289560
		ANK repeat	2492..2521	CDD:293786
		ANK	2519..2645	CDD:238125
		ANK repeat	2523..2589	CDD:293786
		Ank_2	2528..2622	CDD:289560
		ANK repeat	2560..2587	CDD:293786
		ANK repeat	2591..2622	CDD:293786
		KH-I	3049..3110	CDD:238053
PLA2G6	NP_001336793.1	ANK	<103..172	CDD:238125	16/89 (18%)
		ANK repeat	118..149	CDD:293786	5/50 (10%)
		ANK 1. /evidence=ECO:0000250\|UniProtKB:A0A3L7I2I8	120..147		4/46 (9%)
		ANK	147..272	CDD:238125	34/125 (27%)
		ANK repeat	151..183	CDD:293786	8/31 (26%)
		ANK 1. /evidence=ECO:0000255	151..181		8/29 (28%)
		ANK repeat	185..217	CDD:293786	8/31 (26%)
		ANK 2. /evidence=ECO:0000255	185..215		7/29 (24%)
		ANK repeat	219..248	CDD:293786	12/28 (43%)
		ANK 3. /evidence=ECO:0000255	219..248		12/28 (43%)
		ANK 4. /evidence=ECO:0000255	251..281		5/31 (16%)
		ANK	285..403	CDD:238125	35/118 (30%)
		ANK repeat	286..314	CDD:293786	8/28 (29%)
		ANK 5. /evidence=ECO:0000255	286..312		8/26 (31%)
		ANK repeat	316..347	CDD:293786	10/30 (33%)
		ANK 6. /evidence=ECO:0000255	316..345		10/28 (36%)
		ANK repeat	349..380	CDD:293786	10/30 (33%)
		ANK 7. /evidence=ECO:0000255	349..378		10/28 (36%)
		ANK 9. /evidence=ECO:0000250\|UniProtKB:A0A3L7I2I8	382..403		5/20 (25%)
		Pat_PNPLA9	480..793	CDD:132851	51/268 (19%)
		GXGXXG. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	485..490		3/24 (13%)
		GXSXG. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	517..521		0/3 (0%)
		DGA/G. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	652..654		1/1 (100%)
		Calmodulin-binding (1-9-14 motif). /evidence=ECO:0000250\|UniProtKB:A0A3L7I2I8	677..686		1/3 (33%)
		Calmodulin-binding (IQ motif). /evidence=ECO:0000250\|UniProtKB:A0A3L7I2I8	748..759
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156347
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930