DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mask and ANKRD55

DIOPT Version :9

Sequence 1:	NP_001247280.1	Gene:	mask / 50070	FlyBaseID:	FBgn0043884	Length:	4010	Species:	Drosophila melanogaster
Sequence 2:	XP_016865341.1	Gene:	ANKRD55 / 79722	HGNCID:	25681	Length:	623	Species:	Homo sapiens

Alignment Length:	789	Identity:	157/789 - (19%)
Similarity:	260/789 - (32%)	Gaps:	273/789 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   612 LAQVLLAMSAAQVEDKGQKDS------TPLMEAASAGHLDIVKLLLNHNADVNAHC-ATGNTPLM 669
            :.|..:..|...|.|:.:.||      |.:.:|||.|.::.:..::..:..:...| :.|.||||
Human     2 MRQATMDFSTPSVFDQQRGDSSEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLM 66

  Fly   670 FACAGGQVDVVKVLLKHGANVEEQNENGHTPLMEAASAGHVEVAKVLLEHGAGINTHSNEFKESA 734
            .|.:|.|.|.||:|||.|||:..|:..|.|                                  :
Human    67 HAVSGRQADTVKLLLKMGANINMQDAYGRT----------------------------------S 97

  Fly   735 LTLACYKGHLDMVRFLLQAGADQEHKTDEMHTALMEASMDGHVEVARLLLDSGAQVNMPTDSFES 799
            |.||.|.|.|                             :|.|.    ||.:||:.|:|..:...
Human    98 LCLATYLGWL-----------------------------EGCVS----LLRNGAKHNIPDKNGRL 129

  Fly   800 PLTLAACGGHVELATLLIERGANIEEVN---DEGYTPLMEAAREGHEEMVALLLSKGANINATTE 861
            ||..|.....:.|.|:|::: :||.|:|   :||.|||..||.....:...:||.|||:.....:
Human   130 PLHAATAEPDMRLLTVLLQQ-SNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDK 193

  Fly   862 ETQETALTLACCGGFMEVAAFLIKEGANLELGASTPLMEASQEGHTDLVSFLLKKKAN---VHAE 923
            :.:                               |.|..|.|.|:..|.|.:|.....   ::.:
Human   194 DFK-------------------------------TALHWAVQSGNRILCSIILSHHQGPSIINYD 227

  Fly   924 TQTGDTALTHACENGHTDAAGVLLSYGAELEHESEGGRTPLMKACR------------------A 970
            .::|.|.:..|...|.:|           :.||.  .|.|   .|.                  .
Human   228 DESGKTCVHIAAAAGFSD-----------IIHEL--ARVP---ECNLQALDVDDSFLLCALFVPK 276

  Fly   971 GHLCTVKFLIQKGANVNKQTTSNDHTALSLACAGGHQSVVELLLKNNADPFHKLKDNSTMLIEAS 1035
            ||||| ...:|...||:....|.:.||   .|.          ....|.|
Human   277 GHLCT-GLQLQGRPNVSSHCWSWEWTA---TCG----------TSMRARP--------------- 312

  Fly  1036 KGGHTRVVELLFRYPNISPTENAASANVTQAAPTSNQPGPNQMRQKIMKQQLQHQLQQLNAPPGL 1100
                       :..|..:.|...::::..:|.||  :|.|:|..:...|::..:.|.|:......
Human   313 -----------WPMPCTAVTRRVSNSSPKRAEPT--RPPPSQSSRPQKKERRFNVLNQIFCKNKK 364

  Fly  1101 HELSEAARASNQQHFHQQQFSSAGNGSSNIVAMGTGDFLDAGELQLTATAGMSAGAGTS---TTG 1162
            .|.....:..::..:.::..|..    ::|:.  |.|.:                .||:   ..|
Human   365 EEQRAHQKDPSRDRYREEDTSEV----NDIIT--TFDSI----------------VGTNCQEQPG 407

  Fly  1163 SETGMEEYGE-------------------------VGGIDLTTLG---------AQQQEGLIAKS 1193
            .:..|.|:.:                         ...:...|||         |....||  .|
Human   408 DQVAMVEFKKKTSDNSKYLLPEKKPLARKGLPPIRTQSLPPITLGNNFLTASHRATSHAGL--SS 470

  Fly  1194 RLFHLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPPAAGQHQLVPCKHF-----DLDMEHINSL 1253
            ...|:    .|:.|:.:.:|.....:...|.....|..:..:|:...|.:     |..::.:.|:
Human   471 APHHM----AQRSQKSRSEQDLLNNRTGCQMLLDNPWKSDSNQVFSYKVWTVSSSDKLLDRLLSV 531

  Fly  1254 QPPQKAPPAPPVLFHTVCQQPVMQQQQQQLQPGQLKLKAMLPNRNRALKTAEVVEFIDCPVDQQQ 1318
            :|..:....||.|.|  ...|...|..|.|.|.:.|::.:...||..           .|:..|:
Human   532 RPGHQEVSVPPHLRH--LHNPSSGQNFQHLSPNRHKIRDLPFTRNNL-----------APLPDQK 583

  Fly  1319 --PGEQVRT 1325
              .||.:||
Human   584 FLSGEPLRT 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mask	NP_001247280.1	ANK	555..684	CDD:238125	23/78 (29%)
		Ank_2	564..659	CDD:289560	11/52 (21%)
		ANK repeat	596..628	CDD:293786	4/15 (27%)
		ANK	633..751	CDD:238125	32/118 (27%)
		ANK repeat	633..661	CDD:293786	5/27 (19%)
		Ank_2	635..724	CDD:289560	25/89 (28%)
		ANK repeat	663..694	CDD:293786	17/30 (57%)
		ANK repeat	696..724	CDD:293786	2/27 (7%)
		Ank_5	716..771	CDD:290568	6/54 (11%)
		ANK	726..850	CDD:238125	31/126 (25%)
		ANK repeat	730..760	CDD:293786	6/29 (21%)
		ANK repeat	765..794	CDD:293786	7/28 (25%)
		Ank_2	768..859	CDD:289560	30/93 (32%)
		ANK repeat	796..827	CDD:293786	9/30 (30%)
		ANK repeat	829..858	CDD:293786	12/28 (43%)
		ANK repeat	862..894	CDD:293786	0/31 (0%)
		ANK	896..1014	CDD:238125	30/138 (22%)
		ANK repeat	896..923	CDD:293786	8/29 (28%)
		Ank_2	898..989	CDD:289560	25/111 (23%)
		ANK repeat	927..957	CDD:293786	6/29 (21%)
		ANK repeat	959..991	CDD:293786	11/49 (22%)
		ANK	989..>1049	CDD:238125	6/59 (10%)
		ANK repeat	993..1023	CDD:293786	5/29 (17%)
		Ank_4	995..1046	CDD:290365	5/50 (10%)
		ANK	2321..2349	CDD:197603
		ANK repeat	2323..2352	CDD:293786
		Ank_2	2326..2419	CDD:289560
		ANK	2350..2477	CDD:238125
		ANK repeat	2354..2386	CDD:293786
		ANK repeat	2390..2419	CDD:293786
		Ank_2	2393..2486	CDD:289560
		ANK repeat	2421..2452	CDD:293786
		ANK repeat	2456..2486	CDD:293786
		ANK	2457..2579	CDD:238125
		Ank_2	2461..2552	CDD:289560
		ANK repeat	2492..2521	CDD:293786
		ANK	2519..2645	CDD:238125
		ANK repeat	2523..2589	CDD:293786
		Ank_2	2528..2622	CDD:289560
		ANK repeat	2560..2587	CDD:293786
		ANK repeat	2591..2622	CDD:293786
		KH-I	3049..3110	CDD:238053
ANKRD55	XP_016865341.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920