DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mask and ankrd44

DIOPT Version :9

Sequence 1:	NP_001247280.1	Gene:	mask / 50070	FlyBaseID:	FBgn0043884	Length:	4010	Species:	Drosophila melanogaster
Sequence 2:	XP_005167840.1	Gene:	ankrd44 / 561373	ZFINID:	ZDB-GENE-070912-605	Length:	1068	Species:	Danio rerio

Alignment Length:	719	Identity:	197/719 - (27%)
Similarity:	279/719 - (38%)	Gaps:	180/719 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   472 DEEEIDVLQDNDADDEEIDDEDEEEDAP-EVSSFLLDANNKRSSNISALL---EAAANEK----- 527
            |.:||.||.   ...|:::..|.|:.|| ..::||.||      .|:.||   .|..|.|
Zfish    20 DPDEIRVLL---CKSEDVNALDAEKRAPLHAAAFLGDA------EITELLIVSGARVNAKDNMWL 75

  Fly   528 APVLRHATHAIDETKQALTKMRCASSPRDKNGFSRSLVAACTDNDVNTVKRLLCK-------GNV 585
            .|:.|......:|..:.|.:.....:.||||..:...|||..       |.|.|.       .:|
Zfish    76 TPLHRAVASRSEEAVRVLIRHSADVNARDKNWQTPLHVAAAN-------KALRCAEVIIPLLSSV 133

  Fly   586 NLNDAAASTDDGESLLSMACSAGYYELAQVLLAMSA----------------------------- 621
            |::|..     |.:.|..|...|:.|:..:|||..|
Zfish   134 NVSDRG-----GRTALHHAALNGHTEMVSLLLAKGANINAFDKKDCRALHWAAYMGHLDVVCLLV 193

  Fly   622 ---AQVEDKGQKDSTPLMEAASAGHLDIVKLLLNHNADVNAHCATGNTPLMFACAGGQVDVVKVL 683
               |::..|.::..|||..|||.|.:.:||.||:...:::...|.|||.|..||..||..||..|
Zfish   194 SQGAEISCKDKRGYTPLHAAASNGQIAVVKHLLSLAVEIDEANAFGNTALHVACFNGQDAVVSEL 258

  Fly   684 LKHGANVEEQNENGHTPLMEAASAGHVEVA-KVLLEHGAGINTHSNEFK---------------- 731
            :.:||||.:.|..|.|||..||::.|..:. :.|:..||.:|..|.:.|
Zfish   259 IDYGANVSQPNNKGFTPLHFAAASTHGALCLEFLVNSGADVNVQSRDGKSPLHLTAVHGRFTRSQ 323

  Fly   732 ----------------ESALTLACYKGHLDMVRFLLQAGADQEHKTDEMHTALMEASMDGHVEVA 780
                            .:.|.:|...||..::..|:.:|||...:.......|..|:::.|.:..
Zfish   324 TLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLITSGADCTRRGVHGMFPLHLAALNAHADCC 388

  Fly   781 RLLLDSGA------------------QVNMPTDSFESPLTLAACGGHVELATLLIERGANIEEVN 827
            |.||.||.                  |::.|.|...:.|..||.||:||...||:..||:....:
Zfish   389 RKLLSSGRRYSIMCPLSNDSVLSAGFQIDTPDDLGRTCLHAAAAGGNVECVKLLLSSGADHNRRD 453

  Fly   828 DEGYTPLMEAAREGHEEMVALLLSKGANINAT--------------------------------T 860
            ..|.|||..||...|.:.:..|:|.|..||||                                .
Zfish   454 KHGRTPLHYAAASRHFQCLETLVSCGTCINATDQWGRTAVHYAAASDLDRRRRVVLEPESDGVQA 518

  Fly   861 EETQETALTLACCGGFMEVAAFLIKEGANLEL----GASTPLMEASQEGHTDLVSFLLKKKANVH 921
            |..:|.||.|          .||::.||...|    |.|. :..|:..||...:..||.:..|..
Zfish   519 EREKEAALCL----------EFLLQHGAGPSLKDKQGYSA-VHYAAAYGHRHCLKLLLDRDENHQ 572

  Fly   922 AETQTGDT--ALTHACENGHTDAAGVLLSYGAELEHESEGGRTPLMKACRAGHLCTVKFLIQKGA 984
            .:.:...|  .|..|..:||..|..|||....|::...|..||||..|...||......|:..||
Zfish   573 DDMENNQTRSPLHLAAYHGHAQALEVLLEGHCEVDQGDEVDRTPLALAALRGHTDCALTLLNHGA 637

  Fly   985 NVNKQTTSNDHTALSLACAGGHQSVVELLLK--NNADPFHKLKDNS-----TMLIEASKGGHTRV 1042
            :...:.|....|.:.||...||.|.|.|||:  :|||    |.|.:     |.|:.|..|||...
Zfish   638 SPRSRDTVRGRTPIHLAVMNGHTSCVRLLLEDSDNAD----LVDTADSQGQTPLMLAVMGGHVDA 698

  Fly  1043 VELL 1046
            |.||
Zfish   699 VSLL 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mask	NP_001247280.1	ANK	555..684	CDD:238125	46/167 (28%)
		Ank_2	564..659	CDD:289560	31/133 (23%)
		ANK repeat	596..628	CDD:293786	10/63 (16%)
		ANK	633..751	CDD:238125	45/150 (30%)
		ANK repeat	633..661	CDD:293786	11/27 (41%)
		Ank_2	635..724	CDD:289560	36/89 (40%)
		ANK repeat	663..694	CDD:293786	15/30 (50%)
		ANK repeat	696..724	CDD:293786	10/28 (36%)
		Ank_5	716..771	CDD:290568	15/86 (17%)
		ANK	726..850	CDD:238125	39/173 (23%)
		ANK repeat	730..760	CDD:293786	9/61 (15%)
		ANK repeat	765..794	CDD:293786	9/46 (20%)
		Ank_2	768..859	CDD:289560	34/108 (31%)
		ANK repeat	796..827	CDD:293786	11/30 (37%)
		ANK repeat	829..858	CDD:293786	11/28 (39%)
		ANK repeat	862..894	CDD:293786	9/35 (26%)
		ANK	896..1014	CDD:238125	36/119 (30%)
		ANK repeat	896..923	CDD:293786	6/26 (23%)
		Ank_2	898..989	CDD:289560	27/92 (29%)
		ANK repeat	927..957	CDD:293786	10/31 (32%)
		ANK repeat	959..991	CDD:293786	10/31 (32%)
		ANK	989..>1049	CDD:238125	25/65 (38%)
		ANK repeat	993..1023	CDD:293786	13/31 (42%)
		Ank_4	995..1046	CDD:290365	22/57 (39%)
		ANK	2321..2349	CDD:197603
		ANK repeat	2323..2352	CDD:293786
		Ank_2	2326..2419	CDD:289560
		ANK	2350..2477	CDD:238125
		ANK repeat	2354..2386	CDD:293786
		ANK repeat	2390..2419	CDD:293786
		Ank_2	2393..2486	CDD:289560
		ANK repeat	2421..2452	CDD:293786
		ANK repeat	2456..2486	CDD:293786
		ANK	2457..2579	CDD:238125
		Ank_2	2461..2552	CDD:289560
		ANK repeat	2492..2521	CDD:293786
		ANK	2519..2645	CDD:238125
		ANK repeat	2523..2589	CDD:293786
		Ank_2	2528..2622	CDD:289560
		ANK repeat	2560..2587	CDD:293786
		ANK repeat	2591..2622	CDD:293786
		KH-I	3049..3110	CDD:238053
ankrd44	XP_005167840.1	ANK repeat	11..38	CDD:293786	6/20 (30%)
		Ank_2	12..104	CDD:289560	24/92 (26%)
		ANK	35..160	CDD:238125	36/142 (25%)
		ANK repeat	40..71	CDD:293786	12/36 (33%)
		ANK repeat	76..104	CDD:293786	4/27 (15%)
		ANK	101..226	CDD:238125	33/136 (24%)
		ANK repeat	106..137	CDD:293786	9/37 (24%)
		Ank_2	111..203	CDD:289560	19/103 (18%)
		ANK repeat	139..170	CDD:293786	9/35 (26%)
		ANK repeat	172..203	CDD:293786	1/30 (3%)
		Ank_2	177..269	CDD:289560	29/91 (32%)
		ANK repeat	238..266	CDD:293786	14/27 (52%)
		Ank	239..270	CDD:278452	15/30 (50%)
		Ank_5	258..312	CDD:290568	19/53 (36%)
		ANK	269..392	CDD:238125	26/122 (21%)
		ANK repeat	271..302	CDD:293786	11/30 (37%)
		ANK repeat	305..336	CDD:293786	1/30 (3%)
		Ank_4	308..359	CDD:290365	4/50 (8%)
		ANK	333..476	CDD:238125	37/142 (26%)
		ANK repeat	338..369	CDD:293786	8/30 (27%)
		Ank_2	343..453	CDD:289560	30/109 (28%)
		ANK repeat	375..420	CDD:293786	9/44 (20%)
		ANK	417..565	CDD:238125	42/158 (27%)
		ANK repeat	423..453	CDD:293786	11/29 (38%)
		Ank_2	427..542	CDD:289560	35/124 (28%)
		ANK repeat	455..486	CDD:293786	13/30 (43%)
		ANK repeat	488..542	CDD:293786	10/63 (16%)
		Ank_4	545..600	CDD:290365	15/55 (27%)
		ANK repeat	545..577	CDD:293786	8/32 (25%)
		ANK	574..703	CDD:238125	46/133 (35%)
		ANK repeat	579..610	CDD:293786	10/30 (33%)
		Ank_2	584..677	CDD:289560	35/96 (36%)
		ANK repeat	614..643	CDD:293786	10/28 (36%)
		ANK repeat	646..680	CDD:293786	15/37 (41%)
		ANK	647..806	CDD:238125	24/60 (40%)
		ANK repeat	682..713	CDD:293786	9/21 (43%)
		ANK repeat	715..740	CDD:293786
		ANKYR	728..927	CDD:223738
		ANK repeat	748..783	CDD:293786
		ANK repeat	817..850	CDD:293786
		ANK	819..940	CDD:238125
		ANK repeat	852..883	CDD:293786
		ANK	880..1009	CDD:238125
		ANK repeat	885..913	CDD:293786
		Ank_2	890..985	CDD:289560
		ANK repeat	919..952	CDD:293786
		ANK repeat	954..985	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010