back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mask and ANKHD1

DIOPT Version :9

Sequence 1:	NP_001247280.1	Gene:	mask / 50070	FlyBaseID:	FBgn0043884	Length:	4010	Species:	Drosophila melanogaster
Sequence 2:	NP_060217.1	Gene:	ANKHD1 / 54882	HGNCID:	24714	Length:	2542	Species:	Homo sapiens

Alignment Length:	3837	Identity:	1172/3837 - (30%)
Similarity:	1524/3837 - (39%)	Gaps:	1535/3837 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 TTLLMGAAAAAADSNAGAALGGSGAGGSGSSSSVGAVGGARMALNPAVDMANAAVLLKQKLKDAA 347
            |..|.|.|..|      :.:|.||.|||||    |..||     :.|:|...||.:|:     ..
Human    43 TVRLFGEAGPA------SGVGSSGGGGSGS----GTGGG-----DAALDFKLAAAVLR-----TG 87

  Fly   348 AAASASASNRSATSSMSSTASSLSSSAGIVNAISSALQNIITPDTDTDTEFYPQPVTTDLSESEE 412
            ....||.|:....|.:.|                     .|....|.|     .||.
Human    88 GGGGASGSDEDEVSEVES---------------------FILDQEDLD-----NPVL-------- 118

  Fly   413 ESVSEILLAFLCLRPDLLDDIPESDPDSCPHEGEVREDEDETEEESEDSDESEGEEEEEDEEEID 477
            ::.|||.|                                        |..:||
Human   119 KTTSEIFL----------------------------------------SSTAEG----------- 132

  Fly   478 VLQDNDADDEEIDDEDEEEDAPEVSSFLLDANNKRSSNISALLEAA-------ANEKA----PVL 531
                  ||...:|.|.:                   :.:.||||||       |:.||    .||
Human   133 ------ADLRTVDPETQ-------------------ARLEALLEAAGIGKLSTADGKAFADPEVL 172

  Fly   532 RHATH----AIDETKQALTKMRCASSPRDKNGFSRSLVAACTDNDVNTVKRLLCKGNVNLNDAAA 592
            |..|.    |:||...|||:|:..:|.......:|||..||:|.|||.|::||.:|. ::|:
Human   173 RRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGR-SVNE--- 233

  Fly   593 STDDGESLLSMACSAGYYELAQVLLAMSAAQVEDKGQK-DSTPLMEAASAGHLDIVKLLLNHNAD 656
            .|::|||||.:||||||||||||||||. |.|||:|.| |.||||.|:|.|:||||||||.|:||
Human   234 HTEEGESLLCLACSAGYYELAQVLLAMH-ANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDAD 297

  Fly   657 VNAHCATGNTPLMFACAGGQVDVVKVLLKHGANVEEQNENGHTPLMEAASAGHVEVAKVLLEHGA 721
            ||:..|||||.|.:|||||.||:|||||..|||:|:.||||||||||||||||||||:|||:|||
Human   298 VNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGA 362

  Fly   722 GINTHSNEFKESALTLACYKGHLDMVRFLLQAGADQEHKTDEMHTALMEASMDGHVEVARLLLDS 786
            ||||||||||||||||||||||||||||||:|||||||||||||||||||.||||||||||||||
Human   363 GINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDS 427

  Fly   787 GAQVNMPTDSFESPLTLAACGGHVELATLLIERGANIEEVNDEGYTPLMEAAREGHEEMVALLLS 851
            |||||||.|||||||||||||||||||.||||||||:|||||||||||||||||||||||||||:
Human   428 GAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA 492

  Fly   852 KGANINATTEETQETALTLACCGGFMEVAAFLIKEGANLELGASTPLMEASQEGHTDLVSFLLKK 916
            :||||||.|||||||||||||||||.|||.||||.||::|||.||||||||||||.:||.:||..
Human   493 QGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLAS 557

  Fly   917 KANVHAETQTGDTALTHACENGHTDAAGVLLSYGAELEHESEGGRTPLMKACRAGHLCTVKFLIQ 981
            .|||||.|.|||||||:||||||||.|.|||..||:|||||||||||||||.||||||||:|||.
Human   558 GANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLIS 622

  Fly   982 KGANVNKQTTSNDHTALSLACAGGHQSVVELLLKNNADPFHKLKDNSTMLIEASKGGHTRVVELL 1046
            ||||||:.|.:||||.:||||||||.:||||||.:.|||.|:|||.|||||||:|||||.||..|
Human   623 KGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687

  Fly  1047 FRYPNISPTENAASANVTQAAPTSNQPGPNQMRQKIMKQQLQHQLQQLNAPPGLHELSEAARASN 1111
            ..|||
Human   688 LDYPN------------------------------------------------------------ 692

  Fly  1112 QQHFHQQQFSSAGNGSSNIVAMGTGDFLDAGELQLTATAGMSAGAGTSTTGSETGMEEYGEVGGI 1176
                             |::::.|.|.
Human   693 -----------------NVLSVPTTDV-------------------------------------- 702

  Fly  1177 DLTTLGAQQQEGLIAKSRLFHLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQPPAAGQHQLVPCK 1241
                                                            .|..||:..|.|:
Human   703 ------------------------------------------------SQLPPPSQDQSQV---- 715

  Fly  1242 HFDLDMEHINSLQPPQKAPPAPPVLFHTVCQQPVMQQQQQQLQPGQLKLKAMLPNRNRALKTAEV 1306
                                 |.|..||:                     ||:
Human   716 ---------------------PRVPTHTL---------------------AMV------------ 726

  Fly  1307 VEFIDCPVDQQQPGEQVRTQPLGEDGKTPQFACAGEDPRLQRRRGFMPELKKGELPPESSSSDPN 1371
                                                                  :||:
Human   727 ------------------------------------------------------VPPQ------- 730

  Fly  1372 ELALKGADNNQPVPTALDNSACAQIPARNSGGAITHSSEVLQSTAISDRPKVKATNKNNRKQAAA 1436
                      :|..|:.:||                             |.:....|...||.::
Human   731 ----------EPDRTSQENS-----------------------------PALLGVQKGTSKQKSS 756

  Fly  1437 AAAAAAAAAAAAAAAAQHAQQVLPNPMVSIYNNLHLQHPHLQFQQQLQLHHQRVAGLDNAAAAAA 1501
            :...|             .|.:||
Human   757 SLQVA-------------DQDLLP----------------------------------------- 767

  Fly  1502 AAASSANMAYSISPASPLPSPTGSGNYVDQQLQQQSMDVALQRKTAMDDFRGMLETAVNGPRGRK 1566
                      |..|..|                                    ||..|.
Human   768 ----------SFHPYQP------------------------------------LECIVE------ 780

  Fly  1567 DLALNTPQLNFFKDGWHMVGVHNFFGDQPKSPTETPPEMEETTMSSPTEADRLGSEPRAEMKNLA 1631
                                             ||..::.|.       ..|:.:..:|::|:|.
Human   781 ---------------------------------ETEGKLNEL-------GQRISAIEKAQLKSLE 805

  Fly  1632 TLCSAAAAAAAVAAVNKDQVEISSDLESECEDDAEGGAGADCEENTLPPEPIELAAALREDGIIV 1696
            .:..        ..:|||::|   :|:...|:..:
Human   806 LIQG--------EPLNKDKIE---ELKKNREEQVQ------------------------------ 829

  Fly  1697 EEEEDDEEEDDDDEEQDTNSGEVDKLNYDDEDAEVDNDGEVDYIDEDEGGGEGEEEEDDADDDEF 1761

Human   830 ----------------------------------------------------------------- 829

  Fly  1762 FLDEPDSDQGTGNNNNNSKSGASSLPLKQRKMATRLENLILNSQTVCDFPPELSNSELVHVLPQI 1826
                                       |::|:...|:.:
Human   830 ---------------------------KKKKILKELQKV-------------------------- 841

  Fly  1827 SNLKAAANSNAALNSVLQQQLAAASAAAAHAKASVVHQKQQHGEGDQQCEDDGSASASELYSGLE 1891
                     ...|....|||...                                         |
Human   842 ---------ERQLQMKTQQQFTK-----------------------------------------E 856

  Fly  1892 HFANDGEMEDIFQELASSLNYPELAEFSLNQMCKGRFAGNWAQSSGKWTGQEQLVGVVRSPGLIN 1956
            :....|:.:.:                ||:|.|..|  |.:.:..|
Human   857 YLETKGQKDTV----------------SLHQQCSHR--GVFPEGEG------------------- 884

  Fly  1957 PGDVPQDAQRQANLVLLDYPMQQNIQLEQRLLDAEEMHLQQHQQTPLSLLPFTDEQQQQLHHQAL 2021
            .|.:|:|                              |..:        ||..|
Human   885 DGSLPED------------------------------HFSE--------LPQVD----------- 900

  Fly  2022 SNASDFQQHQQLALENDPELKQQLQQNSNARIIKAVAAQHQQQPPTNFVYNVESGDKNAPPVQLL 2086
                       ..|..|.::..:.|...:|..|..|..|....|..||..::.|...|:..:|.:
Human   901 -----------TILFKDNDVDDEQQSPPSAEQIDFVPVQPLSSPQCNFSSDLGSNGTNSLELQKV 954

  Fly  2087 FQLPPHMAQHQAQQQQGVGEPLTEQQQQQLHAEQAHLFQHRTGGQRPPTQSELEQVAQELLLQRS 2151
                       :..||.||:|
Human   955 -----------SGNQQIVGQP-------------------------------------------- 964

  Fly  2152 GQVPAGAPVVGVQAIPLKQKHFNLHPPPCPPTCVQHQVATQTHPASVVVPQPAVGYTQFALQASQ 2216
                                                |:|...|...::|.:|.      .|..:.
Human   965 ------------------------------------QIAITGHDQGLLVQEPD------GLMVAT 987

  Fly  2217 QQQMQQNELSIWPMATPTPAPSSGVSSTKSMPGGIAKKAIDKQSRKERRCVVRQTPAGIQENTKL 2281
            ..|...:.|.....|..|..|:...||:::                 ..|:   ||....:.|
Human   988 PAQTLTDTLDDLIAAVSTRVPTGSNSSSQT-----------------TECL---TPESCSQTT-- 1030

  Fly  2282 HLQPQVATAQQQFLVQNQLAVATTVSLDKTIEIDSETESNHDTALTLACAGGHEELVELLINRGA 2346
                            :.:|..:...:..:::||:.|||||||||||||||||||||.:||.|.|
Human  1031 ----------------SNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDA 1079

  Fly  2347 NIEHRDKKGFTPLILAATAGHDKVVDILLKHSAELEAQSERTKDTPLSLACSGGRYEVVELLLSV 2411
            .||||||||||||||||||||..||:|||....::||||||||||||||||||||.|||:|||:.
Human  1080 KIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLAR 1144

  Fly  2412 GANKEHRNVSDYTPLSLAASGGYVNIIKLLLSHGAEINSRTGSKLGISPLMLAAMNGHTPAVKLL 2476
            ||||||||||||||||||||||||||||:||:.|||||||||||||||||||||||||.||||||
Human  1145 GANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLL 1209

  Fly  2477 LDQGSDINAQIETNRNTALTLACFQGRHEVVSLLLDRRANVEHRAKTGLTPLMEAASGGYIEVGR 2541
            ||.||||||||||||||||||||||||.|||||||||:||||||||||||||||||||||.||||
Human  1210 LDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGR 1274

  Fly  2542 VLLDKGADVNAAPVPTSRDTALTIAADKGHQKFVELLLSRNASVEVKNKKGNSPLWLAAHGGHLS 2606
            |||||||||||.|||:||||||||||||||.||.|||:.|.|.::|:|||||:|||||::|||..
Human  1275 VLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFD 1339

  Fly  2607 VVELLYDHNADIDSQDNRRVSCLMAAFRKGHTKIVKWMVQYVSQFPSDQEMIRFIGTISDKELID 2671
            ||:||....||:|:.|||:::.||:||||||.|:|:::|:.|:|||||.|.:|:|.||:||||:.
Human  1340 VVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIECMRYIATITDKELLK 1404

  Fly  2672 KCFDCMKILRSAKEAQAVKANKNASILLEELDLERTREESRKAAAARRRERKKKKKMEKKEEKRR 2736
            ||..|::.:..||:.||.:|||||||||:|||||::||||||.|.|.:||::|:|:.:||||::|
Human  1405 KCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKKKEEQKR 1469

  Fly  2737 QQQGNGPGGDDMQGDDDDASDKDDDSDKDDEDEEAAPAAAREEGDSGIDQGSCSSGDTKGARFGG 2801
            :|:      :|.:....:.|:..:|.|:::.||:.       |.:..|:..|.::..|.|.
Human  1470 KQE------EDEENKPKENSELPEDEDEEENDEDV-------EQEVPIEPPSATTTTTIGI---- 1517

  Fly  2802 SQSAQAA-------EAAANSVSTNSQGKKNKKQAKNKVLISVEPTQPVITSNSVLKGVCAKKHPA 2859
              ||.:|       :..||.|:|.|..:|||   |||
Human  1518 --SATSATFTNVFGKKRANVVTTPSTNRKNK---KNK---------------------------- 1549

  Fly  2860 VEVVKQPPATQQAAPLKRQLDVKKEEPALKKKEEKNSSSSSSSKREKENLAPKEVALPAKQQPSS 2924
               .|:.|.|......::.:.:.:::....|...:.....:....:.:||...:    ...:.||
Human  1550 ---TKETPPTAHLILPEQHMSLAQQKADKNKINGEPRGGGAGGNSDSDNLDSTD----CNSESSS 1607

  Fly  2925 SSKLQSSESASNINSS-------------TATNTS-------------SANTTRKEVAKPASQTA 2963
            ..|.|......::|||             |:|.||             |.:|:.|.|:.|.|...
Human  1608 GGKSQELNFVMDVNSSKYPSLLLHSQEEKTSTATSKTQTRLEGEVTPNSLSTSYKTVSLPLSSPN 1672

  Fly  2964 SATTLNPAKRTE--VDGWKEVVRKSSAQQTTAVGASGAPLPVTATSSATSVQHHPHHHLANSSSN 3026
            ....|...||.:  .:|||||||:|
Human  1673 IKLNLTSPKRGQKREEGWKEVVRRS---------------------------------------- 1697

  Fly  3027 SSSSLTTSTTTAASSVPEMTCKKVQVPVNAISRVIGRGGSNINAIRATTGAHIEVEKQGKNQSER 3091
                                 ||:.||.:.:||::||||.||.||:..|||||:|:||.....||
Human  1698 ---------------------KKLSVPASVVSRIMGRGGCNITAIQDVTGAHIDVDKQKDKNGER 1741

  Fly  3092 CITIKGLTDATKQAHMLILALIKDPDVDILQMLP----RINSSIKQASSGGASTPMSVGTWDNRT 3152
            .|||:|.|::|:.|..||.|||:||..::..::|    |..:|.|...:..:|   .|||   ..
Human  1742 MITIRGGTESTRYAVQLINALIQDPAKELEDLIPKNHIRTPASTKSIHANFSS---GVGT---TA 1800

  Fly  3153 AAGVNAYTFSSAASTTSTSSSSSASSTTPAG-------------------ASYSNAH-----KQH 3193
            |:..||  |...|.|..||.:::.|:..||.                   .:|.:.|     .|.
Human  1801 ASSKNA--FPLGAPTLVTSQATTLSTFQPANKLNKNVPTNVRSSFPVSLPLAYPHPHFALLAAQT 1863

  Fly  3194 QQQPQSVKGP----SGRSSTSVKS---------NGSSTKVSASSGSGSRSGRAGSSYLAQQQPGR 3245
            .||.:..:.|    .|..|.|..:         |..:|..|....:.||......:.|    |..
Human  1864 MQQIRHPRLPMAQFGGTFSPSPNTWGPFPVRPVNPGNTNSSPKHNNTSRLPNQNGTVL----PSE 1924

  Fly  3246 SSGGGSSNGVIKSKSESSSKSLPAAQKSSTTLGKSSTVSPGAQNFAKAAAIGQSSPKKAEGGATS 3310
            |:|..:::..|     :.|..:.|:|:...|    :|.:|.:......|.:.::||       .:
Human  1925 SAGLATASCPI-----TVSSVVAASQQLCVT----NTRTPSSVRKQLFACVPKTSP-------PA 1973

  Fly  3311 AVVTSAGGRSSGVVAPFGRGKPVAGQGGPAA--TAASNVAQLGSVSGNSNILAGP----IGTFN- 3368
            .|::|.....|.:  |.....|:.....|..  .|:::.|||.|....|.....|    :.|.:
Human  1974 TVISSVTSTCSSL--PSVSSAPITSGQAPTTFLPASTSQAQLSSQKMESFSAVPPTKEKVSTQDQ 2036

  Fly  3369 -VADVAAVNAAAAAGAAAATNSNVKPIAPIAPPSKRVGSPTQVQQQHQTQQQ-------QQQQLP 3425
             :|::...::.|.:.:::|:|:   |.||...||   .|||......|.:.|       ....:|
Human  2037 PMANLCTPSSTANSCSSSASNT---PGAPETHPS---SSPTPTSSNTQEEAQPSSVSDLSPMSMP 2095

  Fly  3426 -----QPAPVPGPQPQQQPLQQQQQQQAPQQQPQQP--NQQQQPQTSQQNLVINTNLLNDLMAAS 3483
                 :|||:....|:......|.....||.....|  :.:.||:.|..::|.|..:..|..:..
Human  2096 FASNSEPAPLTLTSPRMVAADNQDTSNLPQLAVPAPRVSHRMQPRGSFYSMVPNATIHQDPQSIF 2160

  Fly  3484 AAN--TTSDSFSAQLAAKLSSAYSLFSDYQQSQWGKLGDPGIGGGAGAVGDGLPQADASKAPGYN 3546
            ..|  |.:.......|.:||||.::.:..|..                    :..|:.|..|.:.
Human  2161 VTNPVTLTPPQGPPAAVQLSSAVNIMNGSQMH--------------------INPANKSLPPTFG 2205

  Fly  3547 R----NILSSPVGSSKASSNHSTSPPVGNVIQQQQQQQPQSSQQALNIITSGPGGPATAPARSPM 3607
            .    |..||...||:..:|            |.....|.||:.|.:             |...:
Human  2206 PATLFNHFSSLFDSSQVPAN------------QGWGDGPLSSRVATD-------------ASFTV 2245

  Fly  3608 VSANEGNPAVGQPSMNGTQGLGETAPAHSPGVIKPPTATVPIQRHVPMPISAPEAGAPPTFGAIG 3672
            .||..||..:|.        |....|.:|    |.|....|.||....|:..      |:....|
Human  2246 QSAFLGNSVLGH--------LENMHPDNS----KAPGFRPPSQRVSTSPVGL------PSIDPSG 2292

  Fly  3673 SNPASGNNSAAAQAAAAAAASAMIDRQQQNLQNLQTLQNLQRMVGASQQQQPQQQLNYPMDPTSS 3737
            |:|:|       .:|..|:.|.:...:
Human  2293 SSPSS-------SSAPLASFSGIPGTR-------------------------------------- 2312

  Fly  3738 FIVDANNVLRLNPRVIFPQGNTKPPQPPPQGGTQSNVFGGNPGRQPPGTGARQPGGAAAQRWYGG 3802
                           :|.||      |.|.|....|....:|   .|.|.|.....:|.
Human  2313 ---------------VFLQG------PAPVGTPSFNRQHFSP---HPWTSASNSSTSAP------ 2347

  Fly  3803 TLEYPSYTGRDMLHLENGAGGMAGMGSPSAMSPNHDDIRKMPRPIGTERAASWKYNNFNVGGPSL 3867
                |:                  :|.|..:|.:.|  ||:|.||||||.|..:.      |.|:
Human  2348 ----PT------------------LGQPKGVSASQD--RKIPPPIGTERLARIRQ------GGSV 2382

  Fly  3868 NMEDALASVLPP------WAHELKAQPPGLQQPPPPPQSQQQQQQPLNW----LKQQPQQQQYRA 3922
            ....|..|.:.|      |:..:.|...||.                .|    :...|..||...
Human  2383 AQAPAGTSFVAPVGHSGIWSFGVNAVSEGLS----------------GWSQSVMGNHPMHQQLSD 2431

  Fly  3923 YNNGPYPQQQQQHEPMNMPMDYHNMQAPPNMSQQQQQHVNLMPSYGYQHFVGAPGAVDISAHMPD 3987
                  |....||:||.  .|...|.||.|:..|..                |.|.||.|..:|.
Human  2432 ------PSTFSQHQPME--RDDSGMVAPSNIFHQPM----------------ASGFVDFSKGLPI 2472

  Fly  3988 KM 3989
            .|
Human  2473 SM 2474

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.