Protein Alignment mask and NFKBIA

DIOPT Version :10

• Sequence 1: NP_001247280.1
• Gene: mask / 50070
• FlyBaseID: FBgn0043884
• Length: 4010
• Species: Drosophila melanogaster
• Sequence 2: NP_065390.1
• Gene: NFKBIA / 4792
• HGNCID: 7797
• Length: 317
• Species: Homo sapiens
• Alignment Length: 273
• Identity: 73/273 - (26%)
• Similarity: 114/273 - (41%)
• Gaps: 45/273 - (16%)

  Fly  2319 ESNHDTALTLACAGGHEELVELLINRGANIEHRD-KKGFTPLILAATAGHDKVVDILLKHS---- 2378
            :..||:.|.......:|::|:.|  :...:|.:: .:|..|.....|...|..:.:.:.|.
Human    27 DDRHDSGLDSMKDEEYEQMVKEL--QEIRLEPQEVPRGSEPWKQQLTEDGDSFLHLAIIHEEKAL 89

  Fly  2379 ------------AELEAQSERTKDTPLSLACSGGRYEVVELLLSVGANKEHRNVSDYTPLSLAAS 2431
                        |.|..|: ..:.|||.||....:.|:.|.||..|.:.|.|:....|||.||..
Human    90 TMEVIRQVKGDLAFLNFQN-NLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACE 153

  Fly  2432 GGYVNIIKLLLSHGAEINSRTGSKL----------GISPLMLAAMNGHTPAVKLLLDQGSDINAQ 2486
            .|      .|.|.|....|.|...|          |.:.|.||:::|:...|:||:..|:|:|||
Human   154 QG------CLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQ 212

  Fly  2487 IETNRNTALTLACFQGRHEVVSLLLDRRANVEHRAKTGLTPLM----EAASGGYIEVGRVLLDKG 2547
            ...|..|||.||......::|||||...|:|......|.:|..    ..::....::|::.|:
Human   213 EPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLE-- 275

  Fly  2548 ADVNAAPVPTSRD 2560
               |...:|.|.|
Human   276 ---NLQMLPESED 285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mask	NP_001247280.1	ANKYR	584..858	CDD:440430
		ANK repeat	596..628	CDD:293786
		ANK repeat	633..661	CDD:293786
		ANK repeat	663..694	CDD:293786
		ANK repeat	696..724	CDD:293786
		ANK repeat	730..760	CDD:293786
		ANKYR	744..1062	CDD:440430
		ANK repeat	765..794	CDD:293786
		ANK repeat	796..827	CDD:293786
		ANK repeat	829..858	CDD:293786
		ANK repeat	862..894	CDD:293786
		ANK repeat	896..923	CDD:293786
		ANK repeat	927..957	CDD:293786
		ANK repeat	959..991	CDD:293786
		ANK repeat	993..1023	CDD:293786
		ANK	2321..2349	CDD:197603	6/27 (22%)
		ANK repeat	2323..2352	CDD:293786	6/28 (21%)
		ANKYR	2336..2623	CDD:440430	69/256 (27%)
		ANK repeat	2354..2386	CDD:293786	8/47 (17%)
		ANK repeat	2390..2419	CDD:293786	11/28 (39%)
		ANK repeat	2421..2452	CDD:293786	10/30 (33%)
		ANK repeat	2456..2486	CDD:293786	12/39 (31%)
		ANK repeat	2492..2521	CDD:293786	12/28 (43%)
		ANK repeat	2523..2589	CDD:293786	8/42 (19%)
		ANK repeat	2560..2587	CDD:293786	1/1 (100%)
		ANK repeat	2591..2622	CDD:293786
		KH-I_MASK	3047..3116	CDD:411832
NFKBIA	NP_065390.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..39		3/11 (27%)
		Destruction motif. /evidence=ECO:0000269|PubMed:8657102	30..36		3/5 (60%)
		Nuclear export signal. /evidence=ECO:0000269|PubMed:10655476	45..54		2/10 (20%)
		ANK repeat	73..108	CDD:293786	4/34 (12%)
		ANK 1	73..103		2/29 (7%)
		ANKYR	75..>256	CDD:440430	57/187 (30%)
		ANK repeat	110..141	CDD:293786	11/30 (37%)
		ANK 2	110..139		10/28 (36%)
		Nuclear import signal. /evidence=ECO:0000269|PubMed:9566872	110..120		5/9 (56%)
		ANK repeat	143..180	CDD:293786	12/42 (29%)
		ANK 3	143..172		11/34 (32%)
		ANK repeat	182..213	CDD:293786	12/30 (40%)
		ANK 4	182..211		10/28 (36%)
		ANK repeat	216..246	CDD:293786	13/29 (45%)
		ANK 5	216..245		13/28 (46%)