DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mask and Pla2g6

DIOPT Version :9

Sequence 1:NP_001247280.1 Gene:mask / 50070 FlyBaseID:FBgn0043884 Length:4010 Species:Drosophila melanogaster
Sequence 2:XP_006242059.1 Gene:Pla2g6 / 360426 RGDID:628867 Length:868 Species:Rattus norvegicus


Alignment Length:741 Identity:157/741 - (21%)
Similarity:263/741 - (35%) Gaps:193/741 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   495 EEDAPEVSSFLLDANNKRSSNISALLEAAANE-KAPVLRHATHAIDETKQALTKMRCASSPRDKN 558
            |.:|..:.:|     .:.||.:....|::... ...||:|.|..| ....:.|....|.....:.
  Rat   112 ESEADALVNF-----QQYSSQLPPFYESSVQVLHVEVLQHLTDLI-RNHPSWTVTHLAVELGIRE 170

  Fly   559 GFSRSLVAACTDNDVNTVKRLLCKGNVNLNDAAASTDDGESLLSMACSAGYYELAQVLLAMSAAQ 623
            .|..|.:.:|.::..|                    ::|.:.|.:||..|..|:...|:....||
  Rat   171 CFHHSRIISCANSTEN--------------------EEGCTPLHLACRKGDSEILVELVQYCHAQ 215

  Fly   624 VEDKGQKDSTPLMEAASAGHLDIVKLL-LNHNADVNAHCATGNTPLMFACAGGQVDVVKVLLKHG 687
            ::....|..|....|....:..:::|| .|.:|.:|.....|.|||..||..|:.::|:|||...
  Rat   216 MDVTDNKGETAFHYAVQGDNPQVLQLLGKNASAGLNQVNNQGLTPLHLACQMGKQEMVRVLLLCN 280

  Fly   688 ANVEEQNENGHTPLMEAASAGHVEVAKVLLEHGAGINTHSNEFKESALTLACYKGHLDMVRFLLQ 752
            |........|. |:..|........|::::...:. ..||.:.:..|..|...| :.:|.|.||:
  Rat   281 ARCNIMGPGGF-PIHTAMKFSQKGCAEMIISMDSN-QIHSKDPRYGASPLHWAK-NAEMARMLLK 342

  Fly   753 AGADQEHKTDEMHTALMEASMDGHVEVARLLLDSGAQVNMPTDSFESPLTLAACGGHVELATLLI 817
            .|.|.:..:...:|||..|......:...:||..||......:...:||.||....::|:...||
  Rat   343 RGCDVDSTSASGNTALHVAVTRNRFDCVMVLLTYGANAGARGEHGNTPLHLAMSKDNMEMVKALI 407

  Fly   818 ERGANIEEVNDEGYTPLMEAAREG----HEEMVALLLSKGANIN------ATTEE---------- 862
            ..||.::..||.|.||...|::..    .:.::.||.:.||:.:      .:||:          
  Rat   408 VFGAEVDTPNDFGETPAFIASKISKLITRKALLTLLKTVGADYHFPFIQGVSTEQSSAAGPHPFF 472

  Fly   863 ----TQETALTLACCGGFMEVAAFLIKEGANLELGASTPLMEASQEGHTDLVSFLLKKKANVHAE 923
                ||...::|                 .||||....|:..|.:.      :|:|....:    
  Rat   473 SLDRTQPPTISL-----------------NNLELQDLMPVSRARKP------AFILSSMRD---- 510

  Fly   924 TQTGDTALTHACENGHTDAAGVLLSYGAELEHESEGGRTPLMKACRAGHLCT----VKFL----- 979
                             :...:|.:.|:.|.....||.|..........||.    ||.|     
  Rat   511 -----------------EKRRLLSTLGSLLLEAFLGGTTDFQSESHDHLLCLDGGGVKGLVIIQL 558

  Fly   980 ---IQKGANVNKQTTSNDHTALSLACAGGHQSVVELLLKNNA---DPFHKLKD---------NST 1029
               |:|.:.|   .|.:....::....||..::..|..|:.|   ..:.::||         .|.
  Rat   559 LIAIEKASGV---ATKDLFDWVAGTSTGGILALAILHSKSMAYMRGVYFRMKDEVFRGSRPYESG 620

  Fly  1030 MLIEASK---GGHTRVVEL--------------------LFR-------------YPNIS---PT 1055
            .|.|..|   |.||::.::                    |||             .|||:   ||
  Rat   621 PLEEFLKREFGEHTKMTDVKKPKVMLTGTLSDRQPAELHLFRNYDAPEAVREPRCTPNINLKPPT 685

  Fly  1056 ENA-----ASANVTQAAPTSNQPGPNQMRQKIMKQQLQHQLQQLNAPPGLHELSEAARASNQQHF 1115
            :.|     .:|..:.||||..:|....:...::...           |.|..::|.       |.
  Rat   686 QPADQLVWRAARSSGAAPTYFRPNGRFLDGGLLANN-----------PTLDAMTEI-------HE 732

  Fly  1116 HQQQFSSAGNGS-----SNIVAMGTG 1136
            :.|.....|.|:     |.:|::|||
  Rat   733 YNQDMIRKGQGNKVKKLSIVVSLGTG 758

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
maskNP_001247280.1 ANK 555..684 CDD:238125 30/129 (23%)
Ank_2 564..659 CDD:289560 18/95 (19%)
ANK repeat 596..628 CDD:293786 9/31 (29%)
ANK 633..751 CDD:238125 30/118 (25%)
ANK repeat 633..661 CDD:293786 7/28 (25%)
Ank_2 635..724 CDD:289560 22/89 (25%)
ANK repeat 663..694 CDD:293786 12/30 (40%)
ANK repeat 696..724 CDD:293786 4/27 (15%)
Ank_5 716..771 CDD:290568 14/54 (26%)
ANK 726..850 CDD:238125 35/127 (28%)
ANK repeat 730..760 CDD:293786 9/29 (31%)
ANK repeat 765..794 CDD:293786 8/28 (29%)
Ank_2 768..859 CDD:289560 25/100 (25%)
ANK repeat 796..827 CDD:293786 9/30 (30%)
ANK repeat 829..858 CDD:293786 8/38 (21%)
ANK repeat 862..894 CDD:293786 7/45 (16%)
ANK 896..1014 CDD:238125 22/129 (17%)
ANK repeat 896..923 CDD:293786 4/26 (15%)
Ank_2 898..989 CDD:289560 17/102 (17%)
ANK repeat 927..957 CDD:293786 3/29 (10%)
ANK repeat 959..991 CDD:293786 11/43 (26%)
ANK 989..>1049 CDD:238125 18/107 (17%)
ANK repeat 993..1023 CDD:293786 5/32 (16%)
Ank_4 995..1046 CDD:290365 14/85 (16%)
ANK 2321..2349 CDD:197603
ANK repeat 2323..2352 CDD:293786
Ank_2 2326..2419 CDD:289560
ANK 2350..2477 CDD:238125
ANK repeat 2354..2386 CDD:293786
ANK repeat 2390..2419 CDD:293786
Ank_2 2393..2486 CDD:289560
ANK repeat 2421..2452 CDD:293786
ANK repeat 2456..2486 CDD:293786
ANK 2457..2579 CDD:238125
Ank_2 2461..2552 CDD:289560
ANK repeat 2492..2521 CDD:293786
ANK 2519..2645 CDD:238125
ANK repeat 2523..2589 CDD:293786
Ank_2 2528..2622 CDD:289560
ANK repeat 2560..2587 CDD:293786
ANK repeat 2591..2622 CDD:293786
KH-I 3049..3110 CDD:238053
Pla2g6XP_006242059.1 Ank_2 140..220 CDD:289560 20/100 (20%)
ANK repeat 156..186 CDD:293786 5/29 (17%)
ANK 186..309 CDD:238125 34/143 (24%)
ANK repeat 188..220 CDD:293786 9/31 (29%)
Ank_2 193..285 CDD:289560 28/91 (31%)
ANK repeat 222..254 CDD:293786 8/31 (26%)
ANK 251..407 CDD:238125 41/158 (26%)
ANK repeat 256..285 CDD:293786 12/28 (43%)
ANK repeat 323..351 CDD:293786 9/28 (32%)
Ank_2 328..417 CDD:289560 25/89 (28%)
ANK repeat 353..384 CDD:293786 8/30 (27%)
ANKYR <382..>456 CDD:223738 19/73 (26%)
ANK repeat 386..417 CDD:293786 9/30 (30%)
Pat_PNPLA9 542..855 CDD:132851 50/238 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166350281
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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