DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mask and LOC100490559

DIOPT Version :9

Sequence 1:	NP_001247280.1	Gene:	mask / 50070	FlyBaseID:	FBgn0043884	Length:	4010	Species:	Drosophila melanogaster
Sequence 2:	XP_031750905.1	Gene:	LOC100490559 / 100490559	-ID:	-	Length:	764	Species:	Xenopus tropicalis

Alignment Length:	795	Identity:	144/795 - (18%)
Similarity:	251/795 - (31%)	Gaps:	236/795 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1337 FACAGEDPRLQRRRG----------FMPELKKGELPPESSSSDPNELALKGADNNQPVPTALDN- 1390
            :...|||..:.:|..          .|....:..:|..|.||   ..||: .:|.:.|...:.|
Frog    72 YVLTGEDYVVSKRTSAGILQSCGDCMMGGFCQRHVPTVSHSS---RSALQ-RENARKVLELISNI 132

  Fly  1391 --SACAQIPARNSGGAITHSSE---------VLQSTAISDRPKVKATNKNNRKQAAAAAAAAAAA 1444
              ....::..|:.......|||         |..:..|.:.|:.:..::::.|:.|::..:...|
Frog   133 FHMLTEEVAIRHEEAGSYFSSEEWDYLKGNHVFYTEVIKENPQQQLRSQDDGKEEASSIRSYMEA 197

  Fly  1445 AAAAAAAAQHAQQVLP----NPMVSIYNNLHLQHPHLQFQQQLQLHHQRVAGLDNAAAAAAAAAS 1505
            ...:...|.......|    |||                              ||:||
Frog   198 KVISNNKAPKRCSPCPREEGNPM------------------------------DNSAA------- 225

  Fly  1506 SANMAYSISPASPLPSPTGSGNYVDQQLQQQSMDVALQRKTAMDDFRGMLETAVNG-PRGRKDLA 1569
                     |.|..|:.:..|     :..:.|:|....|........|..::::|. ..|.|:..
Frog   226 ---------PISNYPTASWEG-----ERSESSIDPLTGRTLGTMHIWGHSQSSLNDTSMGNKETC 276

  Fly  1570 LNTPQLNFFKDGWHMVGVHNFFGDQPKSPTETPPEMEETTMSSPTEADRLGSEPRAEMKNLATLC 1634
                      ..|.       .|.:.|||.....:..:.| |||.    |||:.|.....
Frog   277 ----------PSWE-------GGGRAKSPIGPHTDPIQGT-SSPV----LGSKLRNRFVK----- 314

  Fly  1635 SAAAAAAAVAAVNKDQVEISSDLESECEDDAEGGAGADCEENTLPPEPI----------ELAAAL 1689
                                   |.....|.||     |...:..|||:          .|.||
Frog   315 -----------------------EESASWDKEG-----CSSYSALPEPVSEPGTPTLHMSLCAA- 350

  Fly  1690 REDGIIVEEEEDDEEEDDDDEEQDTNSGEVDKLNYDDEDAEVDNDGEVDYIDEDEGGGE------ 1748
             ..||  :||....||.:..:...|.:.|..:..:.....     |...:.....|..|
Frog   351 -SSGI--KEEYSPWEEGESVDYSCTLTPEAVQTAHTPAPG-----GPTFHYSRSSGIKEETASRQ 407

  Fly  1749 -GEEEEDDADDDEFFLDEPDSDQGTGNNNNNSKSGASSLPLKQRKMATRLENLILNSQT------ 1806
             ||..|...:..:..:..||....|....|.|.:...|..:|....:.....|..||.|
Frog   408 AGESSEFGINPPKELIRVPDPPTPTIRPTNQSPTIYKSHVIKVESASWGERPLDYNSSTDPIEAA 472

  Fly  1807 -----VCDFP--PELSNSELVHVLPQISNLKAAANSNAALNSVLQQQLAAASAAAAHAK------ 1858
                 :..:|  ..||:.|......:::.::.:|.:.||:.|..:|...:.:..|.|.:
Frog   473 DTSAHITRYPLNNRLSDMEFSDCAAELTRVQLSAPAVAAMYSYAEQPYPSHAGPARHRRTPKGKK 537

  Fly  1859 --------------ASVVHQKQQHGEGDQ-QCEDDG--------SASASELYSGLEHFANDGEME 1900
                          .:::..::.|.||.: .|.:.|        ..|..::::|.:.|| ..|..
Frog   538 LFTCLECGKCFTRNTTLLSHQRSHREGMRLTCAECGLCFPRYSSLVSHQQIHTGGKAFA-CSECG 601

  Fly  1901 DIFQELASSLN----YPELAEFSLNQMCKGRFA--GNWAQSSGKWTGQEQLVGVVRSPGLINPGD 1959
            ..|...:|.||    :|....|:.::..|| |:  .|..:.....||::             |..
Frog   602 LCFARYSSLLNHQKVHPGEKPFACSECGKG-FSRNSNLVRHKRMHTGEK-------------PYS 652

  Fly  1960 VPQDAQ---RQANLV--LLDYPMQQNIQLEQ-RLLDAEEMHLQQHQQTPLSLLPFTDEQQQQLHH 2018
            .|:..:   |.|.|:  |..:.:.:.....| .|.......|..||::.....|:...|    .|
Frog   653 CPECGKCFTRNAALIKHLTAHALGKLFACSQCGLCFTRSATLLSHQKSHAGGQPYPCPQ----CH 713

  Fly  2019 QALSNASDFQQHQQL 2033
            :..:|.:|.::||::
Frog   714 KVFTNVTDLERHQEI 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mask	NP_001247280.1	ANK	555..684	CDD:238125
		Ank_2	564..659	CDD:289560
		ANK repeat	596..628	CDD:293786
		ANK	633..751	CDD:238125
		ANK repeat	633..661	CDD:293786
		Ank_2	635..724	CDD:289560
		ANK repeat	663..694	CDD:293786
		ANK repeat	696..724	CDD:293786
		Ank_5	716..771	CDD:290568
		ANK	726..850	CDD:238125
		ANK repeat	730..760	CDD:293786
		ANK repeat	765..794	CDD:293786
		Ank_2	768..859	CDD:289560
		ANK repeat	796..827	CDD:293786
		ANK repeat	829..858	CDD:293786
		ANK repeat	862..894	CDD:293786
		ANK	896..1014	CDD:238125
		ANK repeat	896..923	CDD:293786
		Ank_2	898..989	CDD:289560
		ANK repeat	927..957	CDD:293786
		ANK repeat	959..991	CDD:293786
		ANK	989..>1049	CDD:238125
		ANK repeat	993..1023	CDD:293786
		Ank_4	995..1046	CDD:290365
		ANK	2321..2349	CDD:197603
		ANK repeat	2323..2352	CDD:293786
		Ank_2	2326..2419	CDD:289560
		ANK	2350..2477	CDD:238125
		ANK repeat	2354..2386	CDD:293786
		ANK repeat	2390..2419	CDD:293786
		Ank_2	2393..2486	CDD:289560
		ANK repeat	2421..2452	CDD:293786
		ANK repeat	2456..2486	CDD:293786
		ANK	2457..2579	CDD:238125
		Ank_2	2461..2552	CDD:289560
		ANK repeat	2492..2521	CDD:293786
		ANK	2519..2645	CDD:238125
		ANK repeat	2523..2589	CDD:293786
		Ank_2	2528..2622	CDD:289560
		ANK repeat	2560..2587	CDD:293786
		ANK repeat	2591..2622	CDD:293786
		KH-I	3049..3110	CDD:238053
LOC100490559	XP_031750905.1	zf-C2H2	539..561	CDD:395048	0/21 (0%)
		C2H2 Zn finger	541..559	CDD:275368	0/17 (0%)
		C2H2 Zn finger	569..589	CDD:275368	3/19 (16%)
		COG5048	<597..744	CDD:227381	31/150 (21%)
		C2H2 Zn finger	597..617	CDD:275368	5/19 (26%)
		C2H2 Zn finger	625..645	CDD:275368	4/20 (20%)
		zf-H2C2_2	637..662	CDD:404364	5/37 (14%)
		C2H2 Zn finger	653..673	CDD:275368	5/19 (26%)
		C2H2 Zn finger	681..701	CDD:275368	5/19 (26%)
		C2H2 Zn finger	709..729	CDD:275368	6/24 (25%)
		C2H2 Zn finger	737..757	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010