DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mask and si:ch1073-398c20.3

DIOPT Version :9

Sequence 1:	NP_001247280.1	Gene:	mask / 50070	FlyBaseID:	FBgn0043884	Length:	4010	Species:	Drosophila melanogaster
Sequence 2:	XP_021331002.1	Gene:	si:ch1073-398c20.3 / 100331458	ZFINID:	ZDB-GENE-161017-19	Length:	418	Species:	Danio rerio

Alignment Length:	506	Identity:	104/506 - (20%)
Similarity:	165/506 - (32%)	Gaps:	142/506 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   455 EEESED-SDESEGEEEEEDEEEIDVLQDNDADDEEIDDEDEEEDAPEVSSFLLDANNKRSSNISA 518
            :||||| ..|.....:.||.|::..|.....:..|::|..||:|..|....:  :..|.|.|
Zfish     5 KEESEDLKIEETFRVKHEDAEQLTDLLPWKEEIPELNDVKEEKDLDEEGHLI--SGVKTSEN--- 64

  Fly   519 LLEAAANEKAPVLRHATHAIDETKQALTKMRCASSPRDKNGFSRSLVAACTDND---VNT-VKRL 579
                :|.:..||            ...|...|          .:||....|.||   ::| .|..
Zfish    65 ----SAQQTGPV------------SCFTCKEC----------GKSLTTKRTLNDHMRIHTGEKPC 103

  Fly   580 LCK--GNVNLNDAAAS----TDDGE-SLLSMACSAGYYELAQVLLAMSAAQVEDK---GQKDSTP 634
            .||  ||..::.:...    |..|| ......|..|:       ...|..:|..:   |||..|
Zfish   104 QCKQCGNRYIDKSTLRRHMITHTGERPFTCQQCGKGF-------TRKSNLEVHTRIHTGQKAFT- 160

  Fly   635 LMEAASAGHLDIVKLLLNHNADVNAHCATGNTPLMFACAG-GQVDVVKVLLKHGANVEEQNENGH 698
               ....||    ......|.:|:....||..|  |.|.. |.....|:||:    |..:...|.
Zfish   161 ---CQQCGH----GFTRKSNLEVHTRIHTGEKP--FICPQCGNCFSRKMLLE----VHMRIHTGK 212

  Fly   699 TPLMEAASAGHVEVAKVLLEHGAGINTHSNE----FKESALTLACYKGHLDMVRFLLQAGADQEH 759
            .| ......|:....|..|:  ..:.||:.|    .:|..::. .||..|            :||
Zfish   213 KP-YACQHCGNSFTRKQSLD--VHMRTHNEERPHICQECGVSF-IYKNSL------------EEH 261

  Fly   760 KTDEMHTA-------------LMEASMDGHVEV-------------ARLLLDSGAQVNMPTDSFE 798
            ..:  ||.             ..:.:::.|:.:             ...:..:....:|.|.:.|
Zfish   262 MRN--HTGEKPFTCQHCGNGFTRKRNLEDHMRIHNEERPHICQECGVSFIYKNSLTEHMTTHTGE 324

  Fly   799 SPLTLAACGGHVELATLLIERGANIEE--VNDEGYTPL-MEAAREGHEEMVALLLSKGANINATT 860
            .|.|...||..       ..|..|:::  :...|..|. .|...:|        .:|.:|:....
Zfish   325 KPFTCQQCGNG-------FTRKRNLKDHMITHTGEKPFTCEQCGKG--------FTKKSNLKVHM 374

  Fly   861 E-ETQETALTLACCGGFMEVAAFLIKEGANLELGASTPLMEASQEGHTDLV 910
            . .|:|...|...||     .:|.:|:  |||......:...|...:|.::
Zfish   375 RVHTEERPYTCEQCG-----KSFTLKD--NLESHRRIHMAGKSHTAYTSII 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mask	NP_001247280.1	ANK	555..684	CDD:238125	33/143 (23%)
		Ank_2	564..659	CDD:289560	25/108 (23%)
		ANK repeat	596..628	CDD:293786	6/35 (17%)
		ANK	633..751	CDD:238125	27/122 (22%)
		ANK repeat	633..661	CDD:293786	5/27 (19%)
		Ank_2	635..724	CDD:289560	19/89 (21%)
		ANK repeat	663..694	CDD:293786	10/31 (32%)
		ANK repeat	696..724	CDD:293786	5/27 (19%)
		Ank_5	716..771	CDD:290568	12/71 (17%)
		ANK	726..850	CDD:238125	24/156 (15%)
		ANK repeat	730..760	CDD:293786	5/29 (17%)
		ANK repeat	765..794	CDD:293786	4/54 (7%)
		Ank_2	768..859	CDD:289560	16/106 (15%)
		ANK repeat	796..827	CDD:293786	7/32 (22%)
		ANK repeat	829..858	CDD:293786	6/29 (21%)
		ANK repeat	862..894	CDD:293786	10/31 (32%)
		ANK	896..1014	CDD:238125	2/15 (13%)
		ANK repeat	896..923	CDD:293786	2/15 (13%)
		Ank_2	898..989	CDD:289560	2/13 (15%)
		ANK repeat	927..957	CDD:293786
		ANK repeat	959..991	CDD:293786
		ANK	989..>1049	CDD:238125
		ANK repeat	993..1023	CDD:293786
		Ank_4	995..1046	CDD:290365
		ANK	2321..2349	CDD:197603
		ANK repeat	2323..2352	CDD:293786
		Ank_2	2326..2419	CDD:289560
		ANK	2350..2477	CDD:238125
		ANK repeat	2354..2386	CDD:293786
		ANK repeat	2390..2419	CDD:293786
		Ank_2	2393..2486	CDD:289560
		ANK repeat	2421..2452	CDD:293786
		ANK repeat	2456..2486	CDD:293786
		ANK	2457..2579	CDD:238125
		Ank_2	2461..2552	CDD:289560
		ANK repeat	2492..2521	CDD:293786
		ANK	2519..2645	CDD:238125
		ANK repeat	2523..2589	CDD:293786
		Ank_2	2528..2622	CDD:289560
		ANK repeat	2560..2587	CDD:293786
		ANK repeat	2591..2622	CDD:293786
		KH-I	3049..3110	CDD:238053
si:ch1073-398c20.3	XP_021331002.1	C2H2 Zn finger	77..97	CDD:275368	6/29 (21%)
		COG5048	90..411	CDD:227381	75/381 (20%)
		C2H2 Zn finger	105..125	CDD:275368	4/19 (21%)
		C2H2 Zn finger	133..153	CDD:275368	4/26 (15%)
		C2H2 Zn finger	161..181	CDD:275368	4/23 (17%)
		C2H2 Zn finger	189..209	CDD:275368	6/23 (26%)
		C2H2 Zn finger	217..237	CDD:275368	3/21 (14%)
		C2H2 Zn finger	245..265	CDD:275368	6/34 (18%)
		C2H2 Zn finger	273..293	CDD:275368	1/19 (5%)
		C2H2 Zn finger	301..321	CDD:275368	1/19 (5%)
		C2H2 Zn finger	329..349	CDD:275368	4/26 (15%)
		C2H2 Zn finger	357..377	CDD:275368	4/27 (15%)
		C2H2 Zn finger	385..405	CDD:275368	7/26 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010