Protein Alignment Hsp70Bbb and Hspa2

DIOPT Version :10

• Sequence 1: NP_788663.1
• Gene: Hsp70Bbb / 50022
• FlyBaseID: FBgn0051354
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_068635.1
• Gene: Hspa2 / 60460
• RGDID: 620664
• Length: 633
• Species: Rattus norvegicus
• Alignment Length: 643
• Identity: 475/643 - (73%)
• Similarity: 544/643 - (84%)
• Gaps: 18/643 - (2%)

  Fly     2 PAIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVFD 66
            ||||||||||||||||:|||||||||||||||||||||||||:||||||.|||||||||.||:||
  Rat     6 PAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTIFD 70

  Fly    67 AKRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEAY 131
            ||||||||::|..:..|||||||:|||:|||||:.||||||.|.|.||||||||||||||.||||
  Rat    71 AKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGEMKTFFPEEISSMVLTKMKEIAEAY 135

  Fly   132 LGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKN--LKDERNVLI 194
            ||..:..|||||||||||||||||||||.|.|||||||||||||||:||||||.  ...|:||||
  Rat   136 LGGKVQSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEKNVLI 200

  Fly   195 FDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSNPRALR 259
            |||||||||||||||::| :|||:||||||||||||||||:|:|||||||||:|||:..|.||:|
  Rat   201 FDLGGGTFDVSILTIEDG-IFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRAVR 264

  Fly   260 RLRTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKM 324
            |||||.|||||||||||:|:||||:|:||.||||.::|||||||.|||||.||:||||||.|||:
  Rat   265 RLRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDAKL 329

  Fly   325 DKGQIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDV 389
            |||||.:||||||||||||:|.|||:||:||.||.|||||||||||||||||||.||:|..:||:
  Rat   330 DKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQDL 394

  Fly   390 LLVDVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQVYEGERAMTKDNNAL 454
            ||:||.||||||||||||||.||:||..||.|||:||:||||||..|.:||||||||||||||.|
  Rat   395 LLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNNLL 459

  Fly   455 GTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNE 519
            |.|||:|||||||||||||||||:||||||||:|.:.||||...|||.|||||||:.:|||||.|
  Rat   460 GKFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMVQE 524

  Fly   520 AEKYADEDEKHRQRITSRNALESYVFNVKQSVE-QAPAGKLDEADKNSVLDKCNETIRWLDSNTT 583
            |:.|..|||.:|.|:.::||:|||.:|:||:|| :...||:.|.|||.:||||.|.|.|||.|..
  Rat   525 ADGYKSEDEANRDRVAAKNAVESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINWLDRNQM 589

  Fly   584 AEKEEFDHKMEELTRHCSPIMTKMHQQGAGAAGGPGANCGQQAGGFGGYSGPTVEEVD 641
            |||:|::||.:||.|.|:||::|::|      |||        ||.|...|||:||||
  Rat   590 AEKDEYEHKQKELERVCNPIISKLYQ------GGP--------GGGGSSGGPTIEEVD 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Bbb	NP_788663.1	PTZ00009	2..641	CDD:240227	473/641 (74%)
Hspa2	NP_068635.1	PTZ00009	2..615	CDD:240227	461/609 (76%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	2..389		311/383 (81%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	397..512		89/114 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	613..633		12/33 (36%)