Protein Alignment Hsp70Bbb and HSPA9

DIOPT Version :10

• Sequence 1: NP_788663.1
• Gene: Hsp70Bbb / 50022
• FlyBaseID: FBgn0051354
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_004125.3
• Gene: HSPA9 / 3313
• HGNCID: 5244
• Length: 679
• Species: Homo sapiens
• Alignment Length: 628
• Identity: 314/628 - (50%)
• Similarity: 426/628 - (67%)
• Gaps: 32/628 - (5%)

  Fly     4 IGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFT-DSERLIGDPAKNQVAMNPRNTVFDA 67
            :|||||||.|||.|.:..:.:::.|.:|.|||||.|||| |.|||:|.|||.|...||.||.:..
Human    56 VGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYAT 120

  Fly    68 KRLIGRKYDDPKIAEDMKHWPFKVV--SDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEA 130
            ||||||:||||::.:|:|:.|||:|  |:|   ...||..|  |.::|.:|.:.||.|||||||.
Human   121 KRLIGRRYDDPEVQKDIKNVPFKIVRASNG---DAWVEAHG--KLYSPSQIGAFVLMKMKETAEN 180

  Fly   131 YLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKDERNVLIF 195
            |||.:..:|||||||||||||||||||||.|:||||||:|||||||||||||||:  :::.:.::
Human   181 YLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKS--EDKVIAVY 243

  Fly   196 DLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSNPRALRR 260
            ||||||||:|||.|.:| :|||:||.|||.|||||||..|:.|:.:||||:...||..:..||:|
Human   244 DLGGGTFDISILEIQKG-VFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQR 307

  Fly   261 LRTAAERAKRTLSSSTEATIEIDALFEG----QDFYTKVSRARFEELCADLFRNTLQPVEKALND 321
            :|.|||:||..||||.:..|.:..|...    :....|::||:||.:..||.|.|:.|.:||:.|
Human   308 VREAAEKAKCELSSSVQTDINLPYLTMDSSGPKHLNMKLTRAQFEGIVTDLIRRTIAPCQKAMQD 372

  Fly   322 AKMDKGQIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKI 386
            |::.|..|.:::||||.||:||||..:|:.| |:..:.::|||||||.|||:|..:|:||    :
Human   373 AEVSKSDIGEVILVGGMTRMPKVQQTVQDLF-GRAPSKAVNPDEAVAIGAAIQGGVLAGD----V 432

  Fly   387 QDVLLVDVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQVYEGERAMTKDN 451
            .||||:||.||||||||.|||.||||.||..||.|:::.|||.:|.|..|.|:|.:|||.|..||
Human   433 TDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDN 497

  Fly   452 NALGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRM 516
            ..||.|.|.|||||||||||||||||:|||||::||||:..||:.:.|.|:: .|.||:.:|:.|
Human   498 KLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQS-SGGLSKDDIENM 561

  Fly   517 VNEAEKYADEDEKHRQRITSRNALESYVFNVKQSVE----QAPAGKLDEADK-NSVLDKCNETIR 576
            |..|||||:||.:.::|:.:.|..|..:.:.:..:|    |.||   ||.:| ...:.|..|.:.
Human   562 VKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPA---DECNKLKEEISKMRELLA 623

  Fly   577 WLDSNTTAEKEEFDHKMEELTRHCSPIMTK---MHQQGAGAAG 616
            ..||.|.....:....:::.:.....:..|   ..::|:|::|
Human   624 RKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSG 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Bbb	NP_788663.1	PTZ00009	2..641	CDD:240227	314/628 (50%)
HSPA9	NP_004125.3	Interaction with NFS1. /evidence=ECO:0000269|PubMed:26702583	1..432		208/388 (54%)
		dnaK	52..673	CDD:234715	314/628 (50%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000303|PubMed:24687350	63..431		200/376 (53%)
		Interaction with FXN and ISCU. /evidence=ECO:0000269|PubMed:26702583	432..679		106/239 (44%)
		Interdomain linker. /evidence=ECO:0000303|PubMed:24687350	432..441		5/8 (63%)
		Substrate-binding domain (SBD). /evidence=ECO:0000303|PubMed:24687350	442..679		100/229 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	656..679		3/11 (27%)