Protein Alignment Hsp70Bbb and HSPA6

DIOPT Version :10

• Sequence 1: NP_788663.1
• Gene: Hsp70Bbb / 50022
• FlyBaseID: FBgn0051354
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_002146.2
• Gene: HSPA6 / 3310
• HGNCID: 5239
• Length: 643
• Species: Homo sapiens
• Alignment Length: 644
• Identity: 458/644 - (71%)
• Similarity: 542/644 - (84%)
• Gaps: 13/644 - (2%)

  Fly     3 AIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVFDA 67
            |:|||||||||||||:|.|:|||:|||||||||||||||||:|||:||.||:|.|:||.||||||
Human     8 AVGIDLGTTYSCVGVFQQGRVEILANDQGNRTTPSYVAFTDTERLVGDAAKSQAALNPHNTVFDA 72

  Fly    68 KRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEAYL 132
            |||||||:.|..:..|||||||:|||:|||||:.|.|:||.|.|.|||||||||:||||||||||
Human    73 KRLIGRKFADTTVQSDMKHWPFRVVSEGGKPKVRVCYRGEDKTFYPEEISSMVLSKMKETAEAYL 137

  Fly   133 GESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKDERNVLIFDL 197
            |:.:..|||||||||||||||||||||.|||||||||||||||||:|||||:....|||||||||
Human   138 GQPVKHAVITVPAYFNDSQRQATKDAGAIAGLNVLRIINEPTAAAIAYGLDRRGAGERNVLIFDL 202

  Fly   198 GGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSNPRALRRLR 262
            ||||||||:|:||.| :|||::|||||||||||||||||.|..|||:||:.|||..|.|||||||
Human   203 GGGTFDVSVLSIDAG-VFEVKATAGDTHLGGEDFDNRLVNHFMEEFRRKHGKDLSGNKRALRRLR 266

  Fly   263 TAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDKG 327
            ||.|||||||||||:||:|||:||||.||||.::||||||||:||||:||:||||||.|||:||.
Human   267 TACERAKRTLSSSTQATLEIDSLFEGVDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKA 331

  Fly   328 QIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLLV 392
            ||||:|||||||||||||.|||:||:||.||.|||||||||||||||||:|.||:..|:||:||:
Human   332 QIHDVVLVGGSTRIPKVQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAVLMGDKCEKVQDLLLL 396

  Fly   393 DVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQVYEGERAMTKDNNALGTF 457
            ||||||||:||||||||.||:||..||.|||:||:|||||||||.|||||||||||||||.||.|
Human   397 DVAPLSLGLETAGGVMTTLIQRNATIPTKQTQTFTTYSDNQPGVFIQVYEGERAMTKDNNLLGRF 461

  Fly   458 DLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNEAEK 522
            :|||||||||||||||||||:||||||:|:|.:.|||||..|||.|||||||:.|::|||:|||:
Human   462 ELSGIPPAPRGVPQIEVTFDIDANGILSVTATDRSTGKANKITITNDKGRLSKEEVERMVHEAEQ 526

  Fly   523 YADEDEKHRQRITSRNALESYVFNVKQSV-EQAPAGKLDEADKNSVLDKCNETIRWLDSNTTAEK 586
            |..|||..|.|:.::|:||::||:||.|: |::...|:.|.|:..:.|||.|.:.||:.|..|||
Human   527 YKAEDEAQRDRVAAKNSLEAHVFHVKGSLQEESLRDKIPEEDRRKMQDKCREVLAWLEHNQLAEK 591

  Fly   587 EEFDHKMEELTRHCSPIMTKMHQQGAGAAGGP----GANCGQQAGGFGGYSGPTVEEVD 641
            ||::|:..||.:.|.||.::::       |||    |::||.||......:||.:||||
Human   592 EEYEHQKRELEQICRPIFSRLY-------GGPGVPGGSSCGTQARQGDPSTGPIIEEVD 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Bbb	NP_788663.1	PTZ00009	2..641	CDD:240227	456/642 (71%)
HSPA6	NP_002146.2	Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	3..388		300/380 (79%)
		PTZ00009	8..643	CDD:240227	456/642 (71%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	396..511		92/114 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	616..643		10/26 (38%)