DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp70Bbb and Hyou1

DIOPT Version :9

Sequence 1:	NP_788663.1	Gene:	Hsp70Bbb / 50022	FlyBaseID:	FBgn0051354	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001029200.1	Gene:	Hyou1 / 192235	RGDID:	621146	Length:	998	Species:	Rattus norvegicus

Alignment Length:	801	Identity:	204/801 - (25%)
Similarity:	343/801 - (42%)	Gaps:	209/801 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPAIGIDLGTTYSCVGVYQHG-KVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTV 64
            :..:.:|||:....|.:.:.| .:||:.|.:..|.||..|...::||.:||.|......||:.|:
  Rat    33 LAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVTVTLKENERFLGDSAAGMAIKNPKATL 97

  Fly    65 FDAKRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGESKR--------FAPEEISSMVL 121
            ...:.|:|::.|:|.:|.....:|        :.::.|:.:.::.|        |:|||:..|||
  Rat    98 RYFQHLLGKQADNPHVALYRSRFP--------EHELNVDPQRQTVRFQISPQLQFSPEEVLGMVL 154

  Fly   122 TKMKETAEAYLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNL 186
            ...:..||.:..:.|.||||||||:||.::|:|...|..:|||.||::||:.||.||:||:.:.
  Rat   155 NYSRSLAEDFAEQPIKDAVITVPAFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRR- 218

  Fly   187 KD----ERNVLIFDLGGGTFDVSILTI------DEGS--LFEVRSTAGDTHLGGEDFDNRLVTHL 239
            ||    .:|::.:|:|.|:...:|:|.      :.|:  ..::|....|..|||.:.:.||..||
  Rat   219 KDINSTAQNIMFYDMGSGSTVCTIVTYQTVKTKEAGTQPQLQIRGVGFDRTLGGLEMELRLREHL 283

  Fly   240 AEEFKRKYK----KDLRSNPRALRRLRTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARF 300
            |:.|..:.|    ||:|.||||:.:|...|.|.|..||::.:...:|:.|.:..||..||:|..|
  Rat   284 AKLFNEQRKGQKAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEF 348

  Fly   301 EELCADLFRNTLQPVEKALNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDE 365
            ||||||||.....||::||..|:|...||..::||||:||:||||.:|.:....:.|..:||.||
  Rat   349 EELCADLFDRVPGPVQQALQSAEMSLDQIEQVILVGGATRVPKVQEVLLKAVGKEELGKNINADE 413

  Fly   366 AVAYGAAVQAAILSGDQSGKIQDVLLVD--VAPL----SLGIETAGGVMTKLIERNCRI------ 418
            |.|.||..|||.||  ::.|::..::.|  :.|:    :..:|...|:  :.::.|.|:
  Rat   414 AAAMGAVYQAAALS--KAFKVKPFVVRDAVIYPILVEFTREVEEEPGL--RSLKHNKRVLFSRMG 474

  Fly   419 --PCKQTKTFSTYSD------NQPGVSIQVYEGERAMTKDNNALGTFDLSGIPPAPRGVPQ---- 471
              |.::..||:.||.      |...:.....|..|.....|  |.|..|.|:..:.:..|.
  Rat   475 PYPQRKVITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQN--LTTVKLKGVGESFKKYPDYESK 537

  Fly   472 -IEVTFDLDANGILNV--------------------------------------SAKEMST---- 493
             |:..|:||.:|:|::                                      .|||..|
  Rat   538 GIKAHFNLDESGVLSLDRVESVFETLVEDSPEEESTLTKLGNTISSLFGGGTSSDAKENGTDAVQ 602

  Fly   494 -------------------------------------------------------GKAKNITIKN 503
                                                                   |........|
  Rat   603 EEEESPAEGSKDEPAEQGELKEEAEAPMEDTSQPPPSEPKGDAAREGETPDEKESGDKSEAQKPN 667

  Fly   504 DKGR---------------------------------------LSQAEIDRMVNEAEKYADEDEK 529
            :||:                                       |.:.|:...|.:.|.....|.:
  Rat   668 EKGQAGPEGVPPAPEEEKKQKPARKQKMVEEIGVELAVLDLPDLPEDELAHSVQKLEDLTLRDLE 732

  Fly   530 HRQRITSRNALESYVFNVKQSVEQAPAGKLD-EADKNSVLDKCNETIRWLDSN----TTAEKEEF 589
            .::|..:.|:||:::|..:..:.|....::. |..:..:..|.:.|..||:..    ||...::
  Rat   733 KQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSATSTWLEDEGFGATTVMLKD- 796

  Fly   590 DHKMEELTRHCSPIMTKMHQQ 610
              |:.||.:.|..:..::.::
  Rat   797 --KLAELRKLCQGLFFRVEER 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Bbb	NP_788663.1	PTZ00009	2..641	CDD:240227	204/800 (26%)
Hsp70Bbb	NP_788663.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	145/400 (36%)
Hyou1	NP_001029200.1	HSP70	35..700	CDD:278441	182/679 (27%)
		HYOU1-like_NBD	36..424	CDD:212672	143/396 (36%)
		RR_TM4-6	549..>706	CDD:283990	10/156 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	564..694		8/129 (6%)
		Prevents secretion from ER. /evidence=ECO:0000255	995..998
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810