Protein Alignment Hsp70Bbb and Hspa4l

DIOPT Version :10

• Sequence 1: NP_788663.1
• Gene: Hsp70Bbb / 50022
• FlyBaseID: FBgn0051354
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_035150.3
• Gene: Hspa4l / 18415
• MGIID: 107422
• Length: 838
• Species: Mus musculus
• Alignment Length: 704
• Identity: 197/704 - (27%)
• Similarity: 345/704 - (49%)
• Gaps: 101/704 - (14%)

  Fly     1 MPAIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVF 65
            |..:|||||.....:.|.:.|.:|.|||:..:|.||:.::.....|.||:.||:|:..|.|||:.
Mouse     1 MSVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNVRNTIH 65

  Fly    66 DAKRLIGRKYDDPKIAEDMKHWPFKVVS-DGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAE 129
            ..|:|.||.:|||.:..:....|:::.. ..|...:.|.|..|.:.||.|:::.|:|.|:|||:|
Mouse    66 GFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSTGVKVRYLEEERPFAIEQVTGMLLAKLKETSE 130

  Fly   130 AYLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDK----NLKDE- 189
            ..|.:.:.|.||::|::|.|::|::...|..:||||.||::||.||.|||||:.|    :|.::
Mouse   131 NALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALAYGIYKQDLPSLDEKP 195

  Fly   190 RNVLIFDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSN 254
            |||:..|:|...:.||:...::|.| :|.:|..|.:|||.:||..||.:..:|||.|||.:::.|
Mouse   196 RNVVFIDMGHSAYQVSVCAFNKGKL-KVLATTFDPYLGGRNFDEALVDYFCDEFKTKYKINVKEN 259

  Fly   255 PRALRRLRTAAERAKRTLS-SSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKA 318
            .|||.||....|:.|:.:| ::::..:.|:......|..:|::||:||:|||.|......|::..
Mouse   260 SRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSKMNRAQFEQLCASLLARVEPPLKSV 324

  Fly   319 LNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQS 383
            ::.|.:.:..|:.|.:|||:||||.|:..:..||. |:::.::|.|||||.|.|:|.||||  .:
Mouse   325 MDQANLQREDINSIEIVGGATRIPAVKEQVTRFFL-KDISTTLNADEAVARGCALQCAILS--PA 386

  Fly   384 GKIQDVLLVDVAPLSLGIE-----TAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQVYEG 443
            .|:::..:.|:.|.|:.:.     ..|....::..:|...|..:..||   ...:|......|..
Mouse   387 FKVREFSITDLVPYSVTLRWKTSFEEGTGECEVFSKNHPAPFSKVITF---HKKEPFELEAFYTN 448

  Fly   444 ERAMTKDNNALGTFDLSGIPPAPRG-VPQIEVTFDLDANGILNVSAKEM---------------- 491
            ...:...:..:|.|.:..:.|...| ..:::|...::.:||.:|::..:
Mouse   449 LHEVPYPDPRIGNFTIQNVFPQSDGDSSKVKVKVRINIHGIFSVASASVIEKQNLEGDHNDAAME 513

  Fly   492 --------------------------------------STG-KAK----------NITIKNDK-- 505
                                                  .|| |||          |.|||..|
Mouse   514 TEAPKSEGKEDVDKMQVDQEEGGHQKCHAEHTPEEEIDHTGAKAKAPPSDKQDRINQTIKKGKIK 578

  Fly   506 -----------GRLSQAEIDRMVNEAEKYADEDEKHRQRITSRNALESYVFNVKQSVEQAPAGKL 559
                       .:|:|..::..:....|...:|:..::|..::||:|.||::.:..:.......:
Mouse   579 SIDLPIQSSLYRQLTQDLLNSYIENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDKLGTVYEKFI 643

  Fly   560 DEADKNSVLDKCNETIRWL-DSNTTAEKEEFDHKMEELTRHCSPIMTKM--HQQ 610
            ...|.|.:.....:|..|| :......|:.:..:::||.::..||..|.  |::
Mouse   644 TPEDMNKLSAMLEDTENWLYEEGEDQPKQVYVDRLQELKKYGQPIQMKYVEHEE 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Bbb	NP_788663.1	PTZ00009	2..641	CDD:240227	196/703 (28%)
Hspa4l	NP_035150.3	ASKHA_NBD_HSP70_HSPA4L	2..384	CDD:466844	143/383 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	506..566		5/59 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	784..838