DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsp70Bbb and T14G8.3

DIOPT Version :9

Sequence 1:	NP_788663.1	Gene:	Hsp70Bbb / 50022	FlyBaseID:	FBgn0051354	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001024913.1	Gene:	T14G8.3 / 181422	WormBaseID:	WBGene00011771	Length:	921	Species:	Caenorhabditis elegans

Alignment Length:	733	Identity:	192/733 - (26%)
Similarity:	328/733 - (44%)	Gaps:	157/733 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPAIGIDLGTTYSCVGVYQHG-KVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTV 64
            :.|:.||||:.:..:|:.:.| .::|:.|.:..|.||:.::|.:.||...:.|....:.:|:::.
Worm    26 LAAMSIDLGSQFIKIGLVKPGVPMDIVLNKESRRKTPNVISFKNDERFFAEAAAAMSSSHPQSSY 90

  Fly    65 FDAKRLIGRKYDDPKIAEDMKHWPFKVVS-DGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETA 128
            .....:|.||..|.......|.:||.... |..:..:...||.|  ::..|.:.:|:|...|:..
Worm    91 NFLLSMIARKEGDDAFVTFQKTFPFTAFEFDEVRKTVVFPYKEE--KYNVETLLAMILWNAKKVT 153

  Fly   129 EAYLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGL--DKNLKDE-R 190
            |||..:::.|.|||||.:.|.::|:|...|..|||||:|:::|:.:||||.||:  .|.:.:: .
Worm   154 EAYADQTVKDVVITVPIFLNQAERRAIASAAEIAGLNLLQLLNDGSAAALNYGVFRRKEITEKPT 218

  Fly   191 NVLIFDLGGGTFDVSILTI----------DEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKR 245
            ::||:|:|......:|:..          |:...........|..|||.:..|||..||.:.|:.
Worm   219 HMLIYDMGAVKTTATIVQYVLESTRKDGKDKQPTLRTVGVGFDKTLGGLEITNRLRDHLEKVFRD 283

  Fly   246 --KYKKDLRSNPRALRRLRTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLF 308
              |..||:.:|.||:.:|...|||.|:.||::.:...::::|||.|:|..||:|...|::..||.
Worm   284 TVKTSKDISTNARAIGKLHKEAERVKQVLSANKDTYAQVESLFEEQNFRAKVTREELEKMIEDLE 348

  Fly   309 RNTLQPVEKALNDAKMDKGQIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAV 373
            .....|:..|:..|::....|..:||:|..||:|||:.:|:.....|.::..:|.|||:|.||..
Worm   349 PRIAAPILDAIGMAQISTNDIDLVVLMGAGTRVPKVKEILKTILKDKEISNFLNTDEAIAMGAVY 413

  Fly   374 QAAILSGDQSGK-----IQDVLLVDVAPLSLGIETAGGVM----TKLIERNCRIPCKQTKTFSTY 429
            |||.||  :|.|     :.:.:|..|. ::...:|..|.|    ..|...|..:| .:...||:|
Worm   414 QAAHLS--KSFKVLPFNVHEKILYPVF-VNFLTKTEEGTMKPIRKSLFGENYPVP-NRVMHFSSY 474

  Fly   430 SDNQPGVSIQVYEGERAMTKDNNALGTFDLSGIPPA-----------PRGVPQIEVTFDLDANGI 483
            ||:   ..|.:.:.      |.|.|.|.::||:..|           .:||   :.||.:|.:||
Worm   475 SDD---FKIDIQDA------DKNPLSTVEISGVKDAIEKEVTDENSVLKGV---KTTFSIDLSGI 527

  Fly   484 LNV-----------------------------------------------SAKEMSTG------- 494
            ::|                                               ..|:.:.|
Worm   528 VSVEKASVVVEKVPTPEEKDKYEVDKKEFDEWEKEQEELKKKEKAEKKEKEEKKKTEGEEEKNED 592

  Fly   495 ----------------------------KAKNITI-------KNDKGRLSQAEI---DRMVNEAE 521
                                        |||.|.:       |.|...|::.|:   .:::.:.|
Worm   593 AAGEEKTEEKTEEVEKPVVVKKTKPVEPKAKKINVALTIKETKTDNIDLNEEEVTAAKKVLGDFE 657

  Fly   522 KYADEDEKHRQRITSRNALESYVFNVKQSVEQAP--AGKLDEADKNSVLDKCNETIRWLDSNTTA 584
            :  .|.||| .|..:.|.||..::::...:|...  |....|.:|.::|::......|.:.:.:.
Worm   658 Q--KEKEKH-DREEAMNRLEGLLYDLAVRLEDGEEYAEYATEEEKKAILEEVAVLKLWFEDDVSL 719

  Fly   585 E--KEEFDH---KMEELT 597
            |  |||||.   |:||||
Worm   720 ETKKEEFDEKRAKLEELT 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Bbb	NP_788663.1	PTZ00009	2..641	CDD:240227	192/732 (26%)
Hsp70Bbb	NP_788663.1	HSPA1-2_6-8-like_NBD	3..379	CDD:212675	123/392 (31%)
T14G8.3	NP_001024913.1	HYOU1-like_NBD	29..416	CDD:212672	120/388 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910