Protein Alignment Hsp70Bbb and Hspa9

DIOPT Version :10

• Sequence 1: NP_788663.1
• Gene: Hsp70Bbb / 50022
• FlyBaseID: FBgn0051354
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_034611.2
• Gene: Hspa9 / 15526
• MGIID: 96245
• Length: 679
• Species: Mus musculus
• Alignment Length: 628
• Identity: 312/628 - (49%)
• Similarity: 424/628 - (67%)
• Gaps: 32/628 - (5%)

  Fly     4 IGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFT-DSERLIGDPAKNQVAMNPRNTVFDA 67
            :|||||||.|||.|.:..:.:::.|.:|.|||||.|||| |.|||:|.|||.|...||.||.:..
Mouse    56 VGIDLGTTNSCVAVMEGKQAKVLENAEGARTTPSVVAFTADGERLVGMPAKRQAVTNPNNTFYAT 120

  Fly    68 KRLIGRKYDDPKIAEDMKHWPFKVV--SDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEA 130
            ||||||:||||::.:|.|:.|||:|  |:|   ...||..|  |.::|.:|.:.||.|||||||.
Mouse   121 KRLIGRRYDDPEVQKDTKNVPFKIVRASNG---DAWVEAHG--KLYSPSQIGAFVLMKMKETAEN 180

  Fly   131 YLGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKDERNVLIF 195
            |||.:..:|||||||||||||||||||||.|:||||||:|||||||||||||||:  :::.:.::
Mouse   181 YLGHTAKNAVITVPAYFNDSQRQATKDAGQISGLNVLRVINEPTAAALAYGLDKS--EDKVIAVY 243

  Fly   196 DLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSNPRALRR 260
            ||||||||:|||.|.:| :|||:||.|||.|||||||..|:.|:.:||||:...||..:..||:|
Mouse   244 DLGGGTFDISILEIQKG-VFEVKSTNGDTFLGGEDFDQALLRHIVKEFKRETGVDLTKDNMALQR 307

  Fly   261 LRTAAERAKRTLSSSTEATIEIDALFEG----QDFYTKVSRARFEELCADLFRNTLQPVEKALND 321
            :|.|||:||..||||.:..|.:..|...    :....|::||:||.:..||.:.|:.|.:||:.|
Mouse   308 VREAAEKAKCELSSSVQTDINLPYLTMDASGPKHLNMKLTRAQFEGIVTDLIKRTIAPCQKAMQD 372

  Fly   322 AKMDKGQIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKI 386
            |::.|..|.:::||||.||:||||..:|:.| |:..:.::|||||||.|||:|..:|:||    :
Mouse   373 AEVSKSDIGEVILVGGMTRMPKVQQTVQDLF-GRAPSKAVNPDEAVAIGAAIQGGVLAGD----V 432

  Fly   387 QDVLLVDVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQVYEGERAMTKDN 451
            .||||:||.||||||||.|||.||||.||..||.|:::.|||.:|.|..|.|:|.:|||.|..||
Mouse   433 TDVLLLDVTPLSLGIETLGGVFTKLINRNTTIPTKKSQVFSTAADGQTQVEIKVCQGEREMAGDN 497

  Fly   452 NALGTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRM 516
            ..||.|.|.|||||||||||||||||:|||||::||||:..||:.:.|.|:: .|.||:.:|:.|
Mouse   498 KLLGQFTLIGIPPAPRGVPQIEVTFDIDANGIVHVSAKDKGTGREQQIVIQS-SGGLSKDDIENM 561

  Fly   517 VNEAEKYADEDEKHRQRITSRNALESYVFNVKQSVE----QAPAGKLDEADK-NSVLDKCNETIR 576
            |..|||||:||.:.::|:.:.|..|..:.:.:..:|    |.||   ||.:| ...:.|....:.
Mouse   562 VKNAEKYAEEDRRKKERVEAVNMAEGIIHDTETKMEEFKDQLPA---DECNKLKEEISKMRALLA 623

  Fly   577 WLDSNTTAEKEEFDHKMEELTRHCSPIMTK---MHQQGAGAAG 616
            ..||.|.....:....:::.:.....:..|   ..::|:|::|
Mouse   624 GKDSETGENIRQAASSLQQASLKLFEMAYKKMASEREGSGSSG 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Bbb	NP_788663.1	PTZ00009	2..641	CDD:240227	312/628 (50%)
Hspa9	NP_034611.2	Interaction with NFS1. /evidence=ECO:0000250|UniProtKB:P38646	1..432		207/388 (53%)
		dnaK	52..673	CDD:234715	312/628 (50%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P38646	63..431		199/376 (53%)
		Interaction with FXN and ISCU. /evidence=ECO:0000250|UniProtKB:P38646	432..679		105/239 (44%)
		Interdomain linker. /evidence=ECO:0000250|UniProtKB:P38646	432..441		5/8 (63%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P38646	442..679		99/229 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	656..679		3/11 (27%)