Protein Alignment Hsp70Bbb and Hspa1l

DIOPT Version :10

• Sequence 1: NP_788663.1
• Gene: Hsp70Bbb / 50022
• FlyBaseID: FBgn0051354
• Length: 641
• Species: Drosophila melanogaster
• Sequence 2: NP_038586.2
• Gene: Hspa1l / 15482
• MGIID: 96231
• Length: 641
• Species: Mus musculus
• Alignment Length: 641
• Identity: 474/641 - (73%)
• Similarity: 552/641 - (86%)
• Gaps: 9/641 - (1%)

  Fly     3 AIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVFDA 67
            |||||||||||||||:|||||||||||||||||||||||||:||||||.|||||||||:||||||
Mouse     8 AIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPQNTVFDA 72

  Fly    68 KRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEAYL 132
            |||||||::||.:..|||.|||:|:::.||||:.|.||||.|.|.||||||||||||||||||:|
Mouse    73 KRLIGRKFNDPVVQSDMKLWPFQVINEAGKPKVMVSYKGEKKAFYPEEISSMVLTKMKETAEAFL 137

  Fly   133 GESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKNLKDERNVLIFDL 197
            |.::|:|||||||||||||||||||||.|||||||||||||||||:||||||....||:||||||
Mouse   138 GHNVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDKGSHGERHVLIFDL 202

  Fly   198 GGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSNPRALRRLR 262
            |||||||||||||:| :|||::|||||||||||||||||:|..||||||:|||:..|.||:||||
Mouse   203 GGGTFDVSILTIDDG-IFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLR 266

  Fly   263 TAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKMDKG 327
            ||.|||||||||||:|.:|||:|:||.||||.::|||||||||||||.||:||||:|.||||||.
Mouse   267 TACERAKRTLSSSTQANLEIDSLYEGIDFYTSITRARFEELCADLFRGTLEPVEKSLRDAKMDKA 331

  Fly   328 QIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLLV 392
            :|||||||||||||||||.|||::|:|::||.|||||||||||||||||||.||:|.|:||:||:
Mouse   332 KIHDIVLVGGSTRIPKVQKLLQDYFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSEKVQDLLLL 396

  Fly   393 DVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQVYEGERAMTKDNNALGTF 457
            ||||||||:||||||||.||:||..||.|||:.|:|||||||||.|||||||||||:|||.||.|
Mouse   397 DVAPLSLGLETAGGVMTVLIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRF 461

  Fly   458 DLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNEAEK 522
            ||:|||||||||||||||||:||||||||:|.:.|||||..|||.|||||||:.||:|||.|||:
Mouse   462 DLTGIPPAPRGVPQIEVTFDIDANGILNVTAMDKSTGKANKITITNDKGRLSKEEIERMVQEAER 526

  Fly   523 YADEDEKHRQRITSRNALESYVFNVKQSV-EQAPAGKLDEADKNSVLDKCNETIRWLDSNTTAEK 586
            |..|||..|::|.::||||||.||:|.:| ::....|:.|:||..:||||||.:.||::|..|||
Mouse   527 YKAEDEGQREKIAAKNALESYAFNMKSAVGDEGLKDKISESDKKKILDKCNEVLSWLEANQLAEK 591

  Fly   587 EEFDHKMEELTRHCSPIMTKMHQQG-AGAAGGPGANCGQQAGGFGGYSGPTVEEVD 641
            :|||||.:||...|:||:||::|.| .|....||...|:.|      :|||:||||
Mouse   592 DEFDHKRKELENMCNPIITKLYQSGCTGPTCTPGYTPGRAA------TGPTIEEVD 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsp70Bbb	NP_788663.1	PTZ00009	2..641	CDD:240227	472/639 (74%)
Hspa1l	NP_038586.2	PTZ00009	3..641	CDD:240227	472/639 (74%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	3..388		307/380 (81%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	396..511		91/114 (80%)