DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsp70Bbb and HSPA12B

DIOPT Version :9

Sequence 1:NP_788663.1 Gene:Hsp70Bbb / 50022 FlyBaseID:FBgn0051354 Length:641 Species:Drosophila melanogaster
Sequence 2:NP_443202.3 Gene:HSPA12B / 116835 HGNCID:16193 Length:686 Species:Homo sapiens


Alignment Length:660 Identity:141/660 - (21%)
Similarity:229/660 - (34%) Gaps:203/660 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 IGIDLGTTYSCVGVYQHGKVEII-------ANDQG--NRTTPSYVAFTDSERLIGDPAKNQVAMN 59
            :.||.|||.|..........|.|       ..|.|  ::.||:.:..|.      :.|.:.....
Human    63 VAIDFGTTSSGYAFSFASDPEAIHMMRKWEGGDPGVAHQKTPTCLLLTP------EGAFHSFGYT 121

  Fly    60 PRNTVFDAKRLIGRKYDDPKIAEDMKHW-PFKV----VSD----------GGKPKIGVEYKGESK 109
            .|:...|.         ||:.|.|..:: .||:    .:|          .||....:|....:.
Human   122 ARDYYHDL---------DPEEARDWLYFEKFKMKIHSATDLTLKTQLEAVNGKTMPALEVFAHAL 177

  Fly   110 RFAPEEISSMVLTKMKETAEAYLGESITDAVITVPAYFNDSQRQATKDAGHIAGL------NVLR 168
            ||..|.    .|.:::|.:.:...:.....|:||||.:....:|..::|.::|||      ..|.
Human   178 RFFREH----ALQELREQSPSLPEKDTVRWVLTVPAIWKQPAKQFMREAAYLAGLVSRENAEQLL 238

  Fly   169 IINEPTAAAL----------------AYG---------LDKNLKDERNVL--------------- 193
            |..||.||::                |.|         :|.:.:..|..|               
Human   239 IALEPEAASVYCRKLRLHQLLDLSGRAPGGGRLGERRSIDSSFRQAREQLRRSRHSRTFLVESGV 303

  Fly   194 --------------IFDLGGGTFDVSILTIDE--GSLFEV-RSTAGDTHLGGED--FDNRLVTHL 239
                          :.|.||||.|:::..:::  |:|.|: :::.|.....|.|  |:..|....
Human   304 GELWAEMQAGDRYVVADCGGGTVDLTVHQLEQPHGTLKELYKASGGPYGAVGVDLAFEQLLCRIF 368

  Fly   240 AEEFKRKYKKDLRSNPRALRRLRTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFE--- 301
            .|:|...:|   |..|.|...|..|.|..|||........:.|...|...|||.|......|   
Human   369 GEDFIATFK---RQRPAAWVDLTIAFEARKRTAGPHRAGALNISLPFSFIDFYRKQRGHNVETAL 430

  Fly   302 --------------------ELCADLFRNT----LQPVEKALNDAKMDKGQIHDIVLVGGSTRIP 342
                                |...:||:.|    :|.:|..|  |:.:...:..:.||||.....
Human   431 RRSSVNFVKWSSQGMLRMSCEAMNELFQPTVSGIIQHIEALL--ARPEVQGVKLLFLVGGFAESA 493

  Fly   343 KVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDVLLVDVAPLSLGIETAGGV 407
            .:|..:|.....:.|.:.:..|..:   ..::.|:|.|...|    |:.|..:||:.|:    ||
Human   494 VLQHAVQAALGARGLRVVVPHDVGL---TILKGAVLFGQAPG----VVRVRRSPLTYGV----GV 547

  Fly   408 MT----------KLIERNCRIPCKQTKTFS-----------------TYSDNQPG---VSIQVY- 441
            :.          ||:.|:.|..|  |..|.                 :|...:||   |.|.:| 
Human   548 LNRFVPGRHPPEKLLVRDGRRWC--TDVFERFVAAEQSVALGEEVRRSYCPARPGQRRVLINLYC 610

  Fly   442 ---EGERAMT----KDNNALGT--------FDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEM 491
               |..|.:|    :...||..        .|.:|.||..|.:.......|.:    :.|:|.::
Human   611 CAAEDARFITDPGVRKCGALSLELEPADCGQDTAGAPPGRREIRAAMQFGDTE----IKVTAVDV 671

  Fly   492 STGKAKNITI 501
            ||.::...:|
Human   672 STNRSVRASI 681

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsp70BbbNP_788663.1 PTZ00009 2..641 CDD:240227 141/660 (21%)
HSPA1-2_6-8-like_NBD 3..379 CDD:212675 102/490 (21%)
HSPA12BNP_443202.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 12..53
NBD_sugar-kinase_HSP70_actin 61..529 CDD:327376 103/492 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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