Protein Alignment Lrrtm4 and Fili

DIOPT Version :10

• Sequence 1: XP_017448300.1
• Gene: Lrrtm4 / 500219
• RGDID: 1560707
• Length: 591
• Species: Rattus norvegicus
• Sequence 2: NP_001369108.1
• Gene: Fili / 5740472
• FlyBaseID: FBgn0085397
• Length: 789
• Species: Drosophila melanogaster
• Alignment Length: 710
• Identity: 156/710 - (21%)
• Similarity: 260/710 - (36%)
• Gaps: 204/710 - (28%)

  Rat    21 PTLLLVMLT------GAQRACPKNCRCDG----KIVYCESHAFADIPENISGGSQGLSLRFNSIQ 75
            |.|||::||      .....||..|:|.|    ....|...|..|:|..::..::.::|..|.|:
  Fly    22 PVLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIR 86

  Rat    76 KLK-----------------------SNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELIL 117
            .|:                       |..|...::|..|.|..|.:||:.:.||:|:..|..|.|
  Fly    87 TLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDL 151

  Rat   118 SSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVP-------- 174
            |.|:|..:|......:.:|..|||:.|.:.:|:...|||:..|.:|..|:|.|..||
  Fly   152 SFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLH 216

  Rat   175 --------IRVFQDCRNLDF--------LDLGYNRLRSLSRNAFAGLLKLKELHLEHN------- 216
                    :.:.:..||..|        |.:..|.:..|..:||.||:.||.|.|..|
  Fly   217 ALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPT 281

  Rat   217 -QFSKIN-----------FAHFP-----RLFNLRSIYL-QWNRIRSVSQGLTWTWSSLHTLDLSG 263
             |.||::           |:..|     .||:||.::| :.:.::.:........:.|.||.|:.
  Fly   282 QQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHLNN 346

  Rat   264 N-DIQAIEPGTFKCLPNLQKLNLDSNKLTNV--SQETVNAWISLISITLSGNMWECSRSICPLFY 325
            | .:..|....|:..||:.::.:.||.|..:  :|..|:   .|..:.|..|..:|:.|:  |:.
  Fly   347 NPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVD---QLQKLYLGDNPLQCNCSL--LWL 406

  Rat   326 W---LKNFKG------NKESTMICAGPKHIQGEKVSDAVETYNICSDVQVVNTERSHLAPQTPQK 381
            |   ..||:|      :.....:.|..|....|:::|  |...:.|....|....:::|.|....
  Fly   407 WRLVTGNFEGVDPGMEHAAGGAVAALAKEADDEELAD--EATAVASTDDGVAALAAYIAEQHIVN 469

  Rat   382 PPFFPKPTIFK-------------------------SDAIPATLEAVSPSPG-FQIPGTDHEYEH 420
            .....:|:.::                         .|.:....:.::.|.| ...|.      |
  Fly   470 ALHTTEPSAYELATSSSNRNSGILRMDRQQIGCDIWRDKVRTRRKLLTMSEGEITCPA------H 528

  Rat   421 VSFHKIIAGSVALFLSVAMI-LLVIYVSWKRYPASMKQLQQHSLMKRRRKKARESERQMNSPLQE 484
            :   ..:..:|...|.|||| :.|:|  :.|:            :|||||...|     ..|::
  Fly   529 I---VTVVCAVITCLLVAMIGISVLY--YLRF------------VKRRRKLLHE-----RGPMR- 570

  Rat   485 YYVDYKPTNSETMDIS---VNGSGP------CTYTISGSRE-------CEMPHHVKPLPYYSYDQ 533
                   |:...:::.   :.|..|      .:.|:.|...       ...|||.:.|
  Fly   571 -------TSKSIINVHDRILQGHNPGGLGLGMSMTLGGGNHVNGLGMTLNYPHHAQTL------- 621

  Rat   534 PVIGYCQAHQPLHI-----------NKAYEAVSIEQDDSPSLELGRDHSFIATIARSAAP 582
                  |||...|.           |..|:..::.|.|...||.......||...|:..|
  Fly   622 ------QAHHHYHQAMPLQSHGGNGNHEYQQTTLPQLDKLELERYLAAQTIANEYRALKP 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lrrtm4	XP_017448300.1	leucine-rich repeat	44..62	CDD:275380	4/17 (24%)
		leucine-rich repeat	65..87	CDD:275380	6/44 (14%)
		LRR	67..>312	CDD:443914	79/319 (25%)
		leucine-rich repeat	88..111	CDD:275380	9/22 (41%)
		leucine-rich repeat	112..135	CDD:275380	7/22 (32%)
		leucine-rich repeat	136..159	CDD:275380	9/22 (41%)
		leucine-rich repeat	160..183	CDD:275380	7/38 (18%)
		leucine-rich repeat	184..207	CDD:275380	8/30 (27%)
		leucine-rich repeat	208..231	CDD:275380	11/46 (24%)
		leucine-rich repeat	232..255	CDD:275380	3/23 (13%)
		leucine-rich repeat	256..279	CDD:275380	7/23 (30%)
		leucine-rich repeat	304..316	CDD:275378	3/11 (27%)
Fili	NP_001369108.1	LRR	71..>348	CDD:443914	67/276 (24%)
		leucine-rich repeat	75..97	CDD:275378	4/21 (19%)
		leucine-rich repeat	98..121	CDD:275380	2/22 (9%)
		leucine-rich repeat	122..145	CDD:275380	9/22 (41%)
		leucine-rich repeat	146..169	CDD:275380	7/22 (32%)
		leucine-rich repeat	170..193	CDD:275380	9/22 (41%)
		leucine-rich repeat	194..217	CDD:275380	7/22 (32%)
		leucine-rich repeat	218..265	CDD:275380	10/46 (22%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	3/22 (14%)
		leucine-rich repeat	314..338	CDD:275380	3/23 (13%)
		LRR_8	337..397	CDD:404697	17/62 (27%)
		leucine-rich repeat	339..360	CDD:275380	7/20 (35%)