DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lrrtm4 and Fili

DIOPT Version :9

Sequence 1:	XP_017448300.1	Gene:	Lrrtm4 / 500219	RGDID:	1560707	Length:	591	Species:	Rattus norvegicus
Sequence 2:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	710	Identity:	156/710 - (21%)
Similarity:	260/710 - (36%)	Gaps:	204/710 - (28%)

- Green bases have known domain annotations that are detailed below.

  Rat    21 PTLLLVMLT------GAQRACPKNCRCDG----KIVYCESHAFADIPENISGGSQGLSLRFNSIQ 75
            |.|||::||      .....||..|:|.|    ....|...|..|:|..::..::.::|..|.|:
  Fly    22 PVLLLLLLTLVILPPETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNPETKYINLTVNRIR 86

  Rat    76 KLK-----------------------SNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELIL 117
            .|:                       |..|...::|..|.|..|.:||:.:.||:|:..|..|.|
  Fly    87 TLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLHKHAFKGLTNLLLLDL 151

  Rat   118 SSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVP-------- 174
            |.|:|..:|......:.:|..|||:.|.:.:|:...|||:..|.:|..|:|.|..||
  Fly   152 SFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLVFRNNRLLDVPASNLWHLH 216

  Rat   175 --------IRVFQDCRNLDF--------LDLGYNRLRSLSRNAFAGLLKLKELHLEHN------- 216
                    :.:.:..||..|        |.:..|.:..|..:||.||:.||.|.|..|
  Fly   217 ALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGLISLKHLDLSDNNLTMVPT 281

  Rat   217 -QFSKIN-----------FAHFP-----RLFNLRSIYL-QWNRIRSVSQGLTWTWSSLHTLDLSG 263
             |.||::           |:..|     .||:||.::| :.:.::.:........:.|.||.|:.
  Fly   282 QQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRIDSRAFVDNTHLQTLHLNN 346

  Rat   264 N-DIQAIEPGTFKCLPNLQKLNLDSNKLTNV--SQETVNAWISLISITLSGNMWECSRSICPLFY 325
            | .:..|....|:..||:.::.:.||.|..:  :|..|:   .|..:.|..|..:|:.|:  |:.
  Fly   347 NPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVD---QLQKLYLGDNPLQCNCSL--LWL 406

  Rat   326 W---LKNFKG------NKESTMICAGPKHIQGEKVSDAVETYNICSDVQVVNTERSHLAPQTPQK 381
            |   ..||:|      :.....:.|..|....|:::|  |...:.|....|....:::|.|....
  Fly   407 WRLVTGNFEGVDPGMEHAAGGAVAALAKEADDEELAD--EATAVASTDDGVAALAAYIAEQHIVN 469

  Rat   382 PPFFPKPTIFK-------------------------SDAIPATLEAVSPSPG-FQIPGTDHEYEH 420
            .....:|:.::                         .|.:....:.::.|.| ...|.      |
  Fly   470 ALHTTEPSAYELATSSSNRNSGILRMDRQQIGCDIWRDKVRTRRKLLTMSEGEITCPA------H 528

  Rat   421 VSFHKIIAGSVALFLSVAMI-LLVIYVSWKRYPASMKQLQQHSLMKRRRKKARESERQMNSPLQE 484
            :   ..:..:|...|.|||| :.|:|  :.|:            :|||||...|     ..|::
  Fly   529 I---VTVVCAVITCLLVAMIGISVLY--YLRF------------VKRRRKLLHE-----RGPMR- 570

  Rat   485 YYVDYKPTNSETMDIS---VNGSGP------CTYTISGSRE-------CEMPHHVKPLPYYSYDQ 533
                   |:...:::.   :.|..|      .:.|:.|...       ...|||.:.|
  Fly   571 -------TSKSIINVHDRILQGHNPGGLGLGMSMTLGGGNHVNGLGMTLNYPHHAQTL------- 621

  Rat   534 PVIGYCQAHQPLHI-----------NKAYEAVSIEQDDSPSLELGRDHSFIATIARSAAP 582
                  |||...|.           |..|:..::.|.|...||.......||...|:..|
  Fly   622 ------QAHHHYHQAMPLQSHGGNGNHEYQQTTLPQLDKLELERYLAAQTIANEYRALKP 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lrrtm4	XP_017448300.1	None
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	4/21 (19%)
		leucine-rich repeat	98..121	CDD:275380	2/22 (9%)
		LRR_8	120..180	CDD:404697	21/59 (36%)
		leucine-rich repeat	122..145	CDD:275380	9/22 (41%)
		leucine-rich repeat	146..169	CDD:275380	7/22 (32%)
		LRR	<161..>354	CDD:227223	46/192 (24%)
		leucine-rich repeat	170..193	CDD:275380	9/22 (41%)
		leucine-rich repeat	194..217	CDD:275380	7/22 (32%)
		leucine-rich repeat	218..265	CDD:275380	10/46 (22%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	3/22 (14%)
		leucine-rich repeat	314..338	CDD:275380	3/23 (13%)
		LRR_8	337..397	CDD:404697	17/62 (27%)
		leucine-rich repeat	339..360	CDD:275380	7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24373
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100