DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45263 and KIRREL3

DIOPT Version :9

Sequence 1:	NP_731246.2	Gene:	CG45263 / 50003	FlyBaseID:	FBgn0266801	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	XP_011541328.1	Gene:	KIRREL3 / 84623	HGNCID:	23204	Length:	809	Species:	Homo sapiens

Alignment Length:	911	Identity:	213/911 - (23%)
Similarity:	349/911 - (38%)	Gaps:	200/911 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SSISTSISSSG-SSTKIAQLLLLIGIAVASC-----LPGSEGFQR--------FSEQPKYTEVNP 65
            :|:...:..|| :|:.:......:|:....|     ....:.|:|        ||:||:...|..
Human     3 ASLGAGLRCSGIASSPLRMQQNELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVVS 67

  Fly    66 AEDTLLTCKVIDKRGTCSWQKDNKPVGIYTKKYEWASRMPTSDNGNVLHLDLHPPPVQLGGDCSL 130
            .:...|.|.:.:..|...|.||...:|:......:...:..   ||           .|.|:..|
Human    68 GQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVV---GN-----------HLSGEHHL 118

  Fly   131 WIRSATLDFDDGLWECQVTASDFTTQDALTSQPVRLVVRVAPQRPRLEYEAVHVPPGHNITADAG 195
            .|..|.|. ||.::|||      ..|.|:.|:|.||.|.|.|..|       .:..|..|:..||
Human   119 KILRAELQ-DDAVYECQ------AIQAAIRSRPARLTVLVPPDDP-------VILGGPVISLRAG 169

  Fly   196 ALATVKCISHYGNPPATLKWFLGDQEISPIHPQMNATEPDNPRTWSAT-----------SVVQVS 249
            ....:.|.:....|.|::.|             :...|..|..|:|.|           |.:.:|
Human   170 DPLNLTCHADNAKPAASIIW-------------LRKGEVINGATYSKTLLRDGKRESIVSTLFIS 221

  Fly   250 AMRERHGDILRCAAYHESYTAKSV----VVEARLDVKYAPSIRLIGSPEIDLEEDKDALVLRCVA 310
            .....:|..:.|.|     |.|::    .....:|:::.|.:.|...|:..||:  :.:...|.|
Human   222 PGDVENGQSIVCRA-----TNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLED--NVVTFHCSA 279

  Fly   311 DANPPASIVWRRAGRSEI----------ASLQETLQLRPVGRRDAGLYTCQAQNSVGTSEQLSVQ 365
            .|| ||...:|.|.|.:|          .::..|....||        :|:..|::| |..||..
Human   280 KAN-PAVTQYRWAKRGQIIKEASGEVYRTTVDYTYFSEPV--------SCEVTNALG-STNLSRT 334

  Fly   366 LDVKYPPKIISAGPDRLTTAP------LFSPAAFECLADGNPLPSFKWVQRMAHGSKYVERGSES 424
            :||.:.|        |:||.|      |.|.|.|.|...|||..:..|::|   ||..| ..:|.
Human   335 VDVYFGP--------RMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKR---GSGVV-LSNEK 387

  Fly   425 RLVIDNVTYEYQGEYECRA-TSYINGQERVAISDPVSLQVVGAPQVLRLHPSLHTVSVKRGEAAS 488
            .|.:.:|..|..|:|.||| ...:...||     .|:|.|.|.|.:    .|..|.....||...
Human   388 TLTLKSVRQEDAGKYVCRAVVPRVGAGER-----EVTLTVNGPPII----SSTQTQHALHGEKGQ 443

  Fly   489 LTMVVCADPRPQRVAWEWGSLRLEAGSGIDRFRADDMQPDTREDCYLSTLHILHADEHDSRPYY- 552
            :...:.:.|.|.|:||.|....||:|:. .|:..:.:   :.|:..:|||.|.:....|.:..|
Human   444 IKCFIRSTPPPDRIAWSWKENVLESGTS-GRYTVETI---STEEGVISTLTISNIVRADFQTIYN 504

  Fly   553 LVVENERGTDRHAIHLIVEGT--------FAEPYEMSYLMGVAGGCMAAILLLVCLCIYAIKSKR 609
            ....|..|:|...|.|..:|:        .||...|:.::|||.|...|.|:|:...:     ..
Human   505 CTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIV-----AF 564

  Fly   610 CCFKG--STGYKS--SDKDSEK---------ADLKSRSDSTSGPQGDSIYTTPA----GFHHHQQ 657
            ||.:.  |||.:|  |.:.:||         |:||....:.:..:.:.::..||    |..|...
Human   565 CCARSQRSTGGRSGISGRGTEKKARLRLPRRANLKGVVSAKNDIRVEIVHKEPASGREGEEHSTI 629

  Fly   658 QQQQQQQQQHAAAAAAAALHAASQHPQQQYPGHGSPEAMKVRMAAMILQPPTRVXQAIDTTSE-- 720
            :|....:.:....:....|....:. ::::..               |:.||....:::|..|
Human   630 KQLMMDRGEFQQDSVLKQLEVLKEE-EKEFQN---------------LKDPTNGYYSVNTFKEHH 678

  Fly   721 SNEQLTQQQQQDDNKNKNKNENEHQNELTDQHTT-SNEQRLDD-----------SSVS--HNNNN 771
            |...::....|.|.:...|.........|:.::| |.:.||.|           ||:.  .....
Human   679 STPTISLSSCQPDLRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMGSSSIELCEREFQ 743

  Fly   772 NHKISSTSTTVLTNSDNNNTS--------EVAKASDSSNSEGGSSLTSSKTSSSKRDLENNMNRD 828
            ...:|.:|:.:.|..|::.:|        :..|||.:|.|....|.:||:.|...|.|:..|...
Human   744 RGSLSDSSSFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRMQTH 808

  Fly   829 I 829
            :
Human   809 V 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45263	NP_731246.2	I-set	53..149	CDD:254352	26/103 (25%)
		Ig	198..281	CDD:299845	16/97 (16%)
		IG_like	302..368	CDD:214653	19/75 (25%)
		IGc2	302..357	CDD:197706	15/64 (23%)
		Ig	372..446	CDD:299845	27/80 (34%)
		Ig	475..568	CDD:299845	25/93 (27%)
		IG_like	478..570	CDD:214653	25/92 (27%)
KIRREL3	XP_011541328.1	Ig	58..149	CDD:299845	29/111 (26%)
		IG_like	60..149	CDD:214653	28/109 (26%)
		I-set	156..249	CDD:254352	21/117 (18%)
		Ig2_KIRREL3-like	171..252	CDD:143236	16/98 (16%)
		Ig_2	260..337	CDD:290606	23/88 (26%)
		I-set	341..422	CDD:254352	31/97 (32%)
		IGc2	355..406	CDD:197706	19/54 (35%)
		Ig5_KIRREL3	424..521	CDD:143306	27/104 (26%)
		IG_like	432..521	CDD:214653	24/92 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910