DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45263 and il1rapl1a

DIOPT Version :9

Sequence 1:	NP_731246.2	Gene:	CG45263 / 50003	FlyBaseID:	FBgn0266801	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	XP_021334418.1	Gene:	il1rapl1a / 568868	ZFINID:	ZDB-GENE-061013-249	Length:	1520	Species:	Danio rerio

Alignment Length:	1185	Identity:	200/1185 - (16%)
Similarity:	345/1185 - (29%)	Gaps:	452/1185 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 WQKDNKPVGI-YTKKYEWASRMPTSDNGNVLHLDLHPPPVQ------LGGDCSLWIRSATLDFDD 141
            |:||.   |: ....:.|.       |...:. |.||.|.|      |||:|..    :|:|...
Zfish   420 WKKDG---GLRICTDFRWL-------NARTMK-DAHPLPHQADCLAALGGNCFF----STMDLTS 469

  Fly   142 GLWECQVTASD-----FTT----------QDALTSQP---VRLVVRV------------------ 170
            |.:...::..|     |||          ...|.:.|   :|:::.:
Zfish   470 GFYNIPMSEEDKKYTAFTTPLGLHEYNRMPQGLCNSPASFMRMMLGIFGDLNFSKLLCYLDDLLV 534

  Fly   171 -APQR-----------PRLEYEAVHVPP-------------GHNITADAGAL----ATVKCISHY 206
             ||..           .||....:.:.|             ||.|  |:|.:    |.|:.|:..
Zfish   535 FAPSESEALSRLRTVFDRLRENNLKLSPKKCHLLQSQVRFLGHII--DSGGVSVDPAKVEVITRM 597

  Fly   207 ---------GNPPAT--LKWFLG----DQEISPIHPQMNATEPDNPRTWSATSVVQVSAMRERHG 256
                     |..|:.  :|.|||    .|...|     |.:....|       :..::|.::|.|
Zfish   598 TAHDLMDNDGCTPSVKRIKSFLGMVFYYQHFIP-----NCSSISKP-------LFGLTAGQKRRG 650

  Fly   257 DILRCAAYHESYTAKSVVVEARLDVKYAPSIRLIGSPEIDLEEDK-DALVLRCVADANP------ 314
            .:.:...:..:|.            |..|:   ..:.|..:..|| ...:|.||..|:|
Zfish   651 KLSKERKFQGTYR------------KLTPA---DWTTECQVAFDKLKTALLECVMLAHPDFNEPF 700

  Fly   315 ----PASIVWRRAGRSEIASLQETLQLRPVGRRDAGLYTCQAQNSVGTSEQLSVQ---------- 365
                .||:....|..|::.  :..||.||:......|.|.|.:......|.::::
Zfish   701 ILSVDASLDGLGAVLSQVP--KGELQARPIAFASKTLSTSQRRYPAHRLEFMALKWSVCEKFSHW 763

  Fly   366 ---------------------------------------LDVKYPPKIISAGPDRLTTAPLFSPA 391
                                                   .|:|:.|...:...|.|:..|...|.
Zfish   764 LKGHKFTIWTDNNPLTYILTKPKLDAYELRWVSKLAAYTFDLKHLPGKANVVADTLSRDPFVEPI 828

  Fly   392 AFECLADGNPLPSFKWVQRMAHG------------SKYVERGSESRLVIDNVTYEYQGEYECRA- 443
            ....|.:     .:.::.:.|.|            |.:::.......:..:|.|...   |.:|
Zfish   829 GRRLLNE-----PYSYLMQEASGIGEDSVHDVFRVSSHIQPNQPMECLSQSVDYNVD---EVKAL 885

  Fly   444 ----TSYINGQERVAISDPVSLQVV-GAPQVLRLHPSLHTVSVKRGEAASLTM-----VVCADPR 498
                .|:.:|.|..|:.....:|:: |..:.|   |.|....:|..:...||:     .:....|
Zfish   886 CQSHCSWTDGAESRALHLVHHVQMISGCQETL---PVLSAQELKDSQQEDLTISKVLSFLIRQRR 947

  Fly   499 PQ------------RVAWEWGSL--------RLEAGSGIDRFRADDMQPDTREDCYLSTLHILHA 543
            |.            |:..:|..|        |:.......|.|...:.||:..:..||.:|.|..
Zfish   948 PSRRERHGASAQVIRLLKQWSKLEVRDDVLYRVTKDPLTKRKRLQYVLPDSLRNKALSGIHDLAG 1012

  Fly   544 DEHDSRPYYLVVENERGTD-----RHAIHLIVEGTFA---EPYEMSYLMGVAGGCMAAILLLVCL 600
            .:...|...|..:.....|     |..:........|   ||...:.|..:..   .|.:.|||:
Zfish  1013 HQGQDRTISLARQRFYWPDMEKNIREYVQCCRRCVLAKSPEPAARAPLENIKS---TAPMELVCI 1074

  Fly   601 CIY-AIKSKRCCF----------KGSTGYKSSDKDSEKADLKSRSDSTSGPQGDSIYTTPAGFHH 654
            ..: |..||:|..          |.:..:..:::.:::. .|...|:..     .||..|...|.
Zfish  1075 DFWSAENSKQCSVDVLVVTDHFTKLAHAFPCANQTAKQV-AKKLWDNVF-----CIYGFPERIHS 1133

  Fly   655 HQQQQ-QQQQQQQHAAAAAAAALHAASQHPQQQYPGHGSPEAMKVRMAAMILQPPTR-------- 710
            .|... :.....:....|..|..|..:.||.    |:|..|.....:..::...|.:
Zfish  1134 DQGTNFESNLIAELLRLAGVAKSHTTAYHPM----GNGGTERFNRTLGNLLRSLPLKEKCQWPQQ 1194

  Fly   711 -----------------------------------------------------------VXQAID 716
                                                                       :..|:|
Zfish  1195 IQTLTFAYNATIHETTGYAPFFLMFGRIPRLPVDIMFNQVLDNPDIADYDSYVKSLLCCLKNAMD 1259

  Fly   717 TTSESNEQLTQQQQQDDNKNK----------------NKNENEHQNELTDQ-----------HTT 754
            ...:.:.  .:|:.|.:..||                ||:| ..:.:|.|:           :..
Zfish  1260 IAQKHSS--VEQRHQANQYNKRVRGTHLSVGDRVLVANKSE-RGKRKLADKWEDGVFTVVEVNPD 1321

  Fly   755 SNEQRLDDSS----VSHNN--------------------NNNHKISSTSTTVLTNSDNNNTSEVA 795
            .:..|:.|:|    |.|.|                    .||..:      ::..||.|...:
Zfish  1322 IHVYRIRDASGRTKVVHRNLLLEVNFLPIVGIDKEQSTSENNQPL------IIVESDQNGADQ-- 1378

  Fly   796 KASDSSNSEGGSSLTSSKTSSSKR----------------------DLENNMNRDIKPATAPKLL 838
               |||......|.|.|...||..                      ||||:.:.|
Zfish  1379 ---DSSEDLSAVSFTESSIQSSSDYPYPLPVCESDRNPVVHVTLPVDLENSHDLD---------- 1430

  Fly   839 HLNVTSGEQQEHQQPGPVDPLPVGPLTPEETQVLLQ------KLSINNPFYRFRKQSNSLKELRR 897
              .|.:.:...||.||..:.||......:::..:.|      .|..::|..|..:.::.:|.:|.
Zfish  1431 --EVDTVDADIHQSPGAANELPTNEKHEQDSNEIAQYLPGSPDLLCSDPSLRGAENADLVKPVRT 1493

  Fly   898 KTGSDAPSVRSRSET 912
            :.|....||....|:
Zfish  1494 RVGRIVKSVNRLIES 1508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45263	NP_731246.2	I-set	53..149	CDD:254352	18/71 (25%)
		Ig	198..281	CDD:299845	17/97 (18%)
		IG_like	302..368	CDD:214653	17/124 (14%)
		IGc2	302..357	CDD:197706	16/64 (25%)
		Ig	372..446	CDD:299845	13/90 (14%)
		Ig	475..568	CDD:299845	22/122 (18%)
		IG_like	478..570	CDD:214653	21/121 (17%)
il1rapl1a	XP_021334418.1	retropepsin_like	46..137	CDD:133136
		RT_LTR	403..579	CDD:238825	32/173 (18%)
		RNase_HI_RT_Ty3	701..823	CDD:260006	17/123 (14%)
		rve	1068..1176	CDD:307008	23/117 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910