DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45263 and kirrel3l

DIOPT Version :9

Sequence 1:	NP_731246.2	Gene:	CG45263 / 50003	FlyBaseID:	FBgn0266801	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	NP_001092814.2	Gene:	kirrel3l / 557315	ZFINID:	ZDB-GENE-070831-1	Length:	755	Species:	Danio rerio

Alignment Length:	825	Identity:	185/825 - (22%)
Similarity:	293/825 - (35%)	Gaps:	216/825 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LIGIAVASCLPGS-EGFQRFSEQPKYTEVNPAEDTLLTCKVIDKRGTCSWQKDNKPVGIYTKKYE 99
            ::...:|.||.|: .....||:||:...|...:...|.|.::..||...|.||...:|.......
Zfish     1 MLAFYIALCLLGTVSQAAYFSQQPQDQVVVAGQSVTLPCVIVGYRGMVQWTKDGLALGGERDLPG 65

  Fly   100 WASRMPTSDNGNVLHLDLHPPPVQLGGDCSLWIRSATLDFDDGLWECQVTASDFTTQDALTSQPV 164
            |.......|              .|.|:.||.|.||.|. ||.::|||      .||..|.|...
Zfish    66 WVRYSLMGD--------------PLSGEHSLVIDSAELG-DDAIYECQ------ATQAGLRSHRA 109

  Fly   165 RLVVRVAPQRPRLEYEAV-----HVPPGHNITADAGALATVKCISHYGNPPATLKWFLGDQEISP 224
            :|.|.|.|..|.:|...|     |.|  ||:|          |.:....|.|.:.|: .|.||..
Zfish   110 KLTVLVPPSDPIVEGGPVVRLKAHTP--HNLT----------CRASGAKPAAEITWY-RDGEIMQ 161

  Fly   225 IHPQMNATEPDNPRTWSATSVVQVSAMRERHGDILRCAAYHESYTA---KSVVVEARLDVKYAPS 286
            ......:...|..|. :|.|::.:.......|....|...:.:..|   .||.:    :|::.||
Zfish   162 NAIYSKSLMEDGKRE-TAVSMLPMVPEDSDSGRTYTCRVLNPAAPAGRQTSVTI----NVQHPPS 221

  Fly   287 IRLIGSPEIDLEEDKDALVLRCVADANPP-ASIVWRRAGRSEIASLQETLQLRPVGRRDAGLYT- 349
            :.|...|:..:|..|  ::..|.|.|||. ....|.:.|.....:..::|::    ..|...:|
Zfish   222 VTLSVQPQTVMEGAK--VLFICSASANPEITGYRWSKGGVPISEANGDSLEV----TADHSYFTD 280

  Fly   350 ---CQAQNSVGTSEQLSVQLDVKYPPKIISAGPDRLTTAPLFSPAAFECLADGNPLPSFKWVQRM 411
               |:..|||| |..:|..:||::.|::::....::....:  .|||.|...|||..:..|.::
Zfish   281 PVSCEVSNSVG-STNVSTLVDVQFGPRLLTEPKPQIVDIGM--DAAFTCSWTGNPPLTLAWTKQ- 341

  Fly   412 AHGSKYVERGSESRLVIDNVTYEYQGEYECRATSYINGQERVAISDPVSLQVVGAPQVLRLHPSL 476
              ||..|...|.: |.:..||.:..|.|.|:|.     ..|:.:::......|..|.::....:.
Zfish   342 --GSNVVLSNSNT-LQLKAVTQDDTGTYTCKAI-----VPRIGVAERDVTLTVNGPPIITAEATQ 398

  Fly   477 HTVSVKRGEAASLTMVVCADPRPQRVAWEWGSLRLEAGSGIDRFRADDMQPDTREDCYLSTLHIL 541
            ..:...:|:   |..:|.:.|.|.::.|.:|.:.|.:||. .||....:..|   ...||:|.:.
Zfish   399 QAIKHSKGK---LECLVGSSPPPDKIVWTFGDMMLSSGSS-GRFSVQTVNSD---QGVLSSLILS 456

  Fly   542 HADEHDSR-PYYLVVENERGTDRHAIHLIVEGTFAEPYEMSYLMGVAGGCMAAILLLVCLCIYAI 605
            .....|.: .|.....|..||....:.|  |...|.|..:.....|.|||:..:.::..:.|
Zfish   457 ETLAQDFQLRYNCTAWNRFGTGTALVTL--EEQEALPLLIIIGASVGGGCVFIVCVITLVSI--- 516

  Fly   606 KSKRCC---FKGSTGYKSS---------------------------------------------- 621
                ||   .||..|.:.|
Zfish   517 ----CCRHNAKGKKGTRLSKSDIRVQIVHSDHNAARGNDDEEDVKEPMAPNSSESPGTSRTEHSD 577

  Fly   622 ---DKDSEKADLKSRSDSTSG---------------------------------PQGDSIY---- 646
               ::|.|::|:|   |.|:|                                 |....:|
Zfish   578 LLEEEDDERSDIK---DPTNGYYNVRAHEDRHITRTGFSEYANNARPVYTPTQLPSPSPLYGQHS 639

  Fly   647 -------------TTPAGFHHHQQQQQQQQQQQHAAAAAAAALHAASQHPQQQ-YPGHGSPEAMK 697
                         ||||....::|||.||.|||.....|         :||:. |.|.....|..
Zfish   640 TQPRIYDFSQRYATTPANRTTYEQQQPQQPQQQPQTPTA---------YPQETVYSGSTYLPATY 695

  Fly   698 VRMAAMILQPPT--------RVXQAIDTTSES-----NEQLTQQQ 729
            .|.....::|.:        .. ||...:|.|     :.|::.||
Zfish   696 GRAFTSYVKPASYEKVDGYEHSDQASKVSSSSRFSYASSQVSSQQ 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45263	NP_731246.2	I-set	53..149	CDD:254352	28/95 (29%)
		Ig	198..281	CDD:299845	16/85 (19%)
		IG_like	302..368	CDD:214653	17/70 (24%)
		IGc2	302..357	CDD:197706	13/59 (22%)
		Ig	372..446	CDD:299845	20/73 (27%)
		Ig	475..568	CDD:299845	21/93 (23%)
		IG_like	478..570	CDD:214653	22/92 (24%)
kirrel3l	NP_001092814.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910