DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45263 and KIRREL1

DIOPT Version :9

Sequence 1:	NP_731246.2	Gene:	CG45263 / 50003	FlyBaseID:	FBgn0266801	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	XP_005245362.1	Gene:	KIRREL1 / 55243	HGNCID:	15734	Length:	773	Species:	Homo sapiens

Alignment Length:	941	Identity:	206/941 - (21%)
Similarity:	337/941 - (35%)	Gaps:	247/941 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 SEGFQ-RFSEQPKYTEVNPAEDTLLTCKVIDKRGTCSWQKDNKPVGIYTKKYEWAS-RMPTSDNG 110
            |:|.| |||::|....|...:..:|.|.:::..|...|.||...:|:......|.. |:..|.:
Human    16 SQGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSAD- 79

  Fly   111 NVLHLDLHPPPVQLGGDCSLWIRSATLDFDDGLWECQVTASDFTTQDALTSQPVRLVVRVAPQRP 175
                          .|..:|.|..|.|. ||..:|||      .|:.||.|:..:|.|.:.|:..
Human    80 --------------AGQYNLEITDAELS-DDASYECQ------ATEAALRSRRAKLTVLIPPEDT 123

  Fly   176 RLEYEAVHVPPGHNITADAGALATVKCISHYGNPPATLKWFL-GDQEISPIHPQMNATE--PDNP 237
            |::       .|..|...||....:.|.:....|.||:.||. |.|:...:    .:||  .|..
Human   124 RID-------GGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAV----ASTELLKDGK 177

  Fly   238 RTWSATSVVQVSAMRERHGDILRCAAYHESY-TAKSVVVEARLDVKYAPSIRLIGSPEIDLEEDK 301
            |. :..|.:.::......|.:..|.:.:|:. :.|...:|  |||.:.|::.|...|:...|.::
Human   178 RE-TTVSQLLINPTDLDIGRVFTCRSMNEAIPSGKETSIE--LDVHHPPTVTLSIEPQTVQEGER 239

  Fly   302 DALVLRCVADANPP-ASIVWRRAGRSEIASLQETLQLRPVGRRDAGLYT----CQAQNSVGTSEQ 361
              :|..|.|.|||. ....|.:.|    ..:::..:.|.....|...:|    |:..|.|| |..
Human   240 --VVFTCQATANPEILGYRWAKGG----FLIEDAHESRYETNVDYSFFTEPVSCEVHNKVG-STN 297

  Fly   362 LSVQLDVKYPPKIISAGPDRLTTAPLFSPAAFECLADGNPLPSFKWVQRMAH------GS----- 415
            :|..::|.:.|:|: ..| :.||..:.|.....|:..|||..:..|.::.::      ||
Human   298 VSTLVNVHFAPRIV-VDP-KPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMGPRPPGSPPEAA 360

  Fly   416 -KYVERGSESRLVIDNVTYEYQGEYECRATSYINGQERVAISD-PVSLQVVGAPQVLRLHPSLHT 478
             ......:.::|::.:||....|.|.|||.     ..|:.::: .|.|.|.|.|.:     |...
Human   361 LSAQVLSNSNQLLLKSVTQADAGTYTCRAI-----VPRIGVAEREVPLYVNGPPII-----SSEA 415

  Fly   479 VS-VKRGEAASLTMVVCADPRPQRVAWEWGSLRLEAGSGIDRFRADDMQPDTREDCYLSTLHILH 542
            |. ..||:...:...:.:.|.|.|:||.|....||.|: ::|:..:.....:.   .||||.|.:
Human   416 VQYAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGT-LERYTVERTNSGSG---VLSTLTINN 476

  Fly   543 ADEHDSRPYY-LVVENERGTDRHAIHLIVEGTFAEPYEMSYLMGVAGGCMAAILLLV---CLCIY 603
            ..|.|.:.:| ....|..|.....|.|       |..|:..:..:||..:.|.:||:   ...::
Human   477 VMEADFQTHYNCTAWNSFGPGTAIIQL-------EEREVLPVGIIAGATIGASILLIFFFIALVF 534

  Fly   604 AIKSKRCCFKGSTGYKSSDKDSEKADLKSRSDSTSGPQGDSIYTTPAGFHHHQQQQQQQQQQQHA 668
            .:..:|   |||    ..|....|.|:|.          :::...|...|        ..::...
Human   535 FLYRRR---KGS----RKDVTLRKLDIKV----------ETVNREPLTMH--------SDREDDT 574

  Fly   669 AAAAAAALHAASQHPQQQYPGHGSPEAMKVRMAAMILQPPTRVXQAIDTTSESNEQLTQQQQQDD 733
            |:.:.|                                  |||.:||.::.:.:..|.|..:
Human   575 ASVSTA----------------------------------TRVMKAIYSSFKDDVDLKQDLR--- 602

  Fly   734 NKNKNKNENEHQNELTDQHTTSNEQRLDDSSVSHNNNNNHKISSTSTTVL---------TNSDNN 789
                           .|...|..|..:.|.:..:.|...|:...:|..||         ...|..
Human   603 ---------------CDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPARFDGR 652

  Fly   790 NTSEVAKASDSSNSEGGSSLTSSKTSSSKRDLENNMNRDIKPATAPKLLHLNVTSGEQQEHQQPG 854
            .:|.:      |:|.|.:.|             |..:|.  ||:                  ..|
Human   653 PSSRL------SHSSGYAQL-------------NTYSRG--PAS------------------DYG 678

  Fly   855 PVDPLPVGPLTPEETQVLLQKLSINN---------------PFYRFRKQSNSLKELRR------- 897
            | :|.|.||..|..|....| ||..|               |.||..........|.|
Human   679 P-EPTPPGPAAPAGTDTTSQ-LSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYD 741

  Fly   898 KTGSDAPSVR---SRSETDLGQVRGQQLMPH 925
            ..|..|.:.|   :...:|.||...|::..|
Human   742 PIGKYATATRFSYTSQHSDYGQRFQQRMQTH 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45263	NP_731246.2	I-set	53..149	CDD:254352	25/96 (26%)
		Ig	198..281	CDD:299845	19/86 (22%)
		IG_like	302..368	CDD:214653	17/70 (24%)
		IGc2	302..357	CDD:197706	13/59 (22%)
		Ig	372..446	CDD:299845	21/85 (25%)
		Ig	475..568	CDD:299845	25/94 (27%)
		IG_like	478..570	CDD:214653	25/93 (27%)
KIRREL1	XP_005245362.1	I-set	22..116	CDD:254352	30/115 (26%)
		Ig	25..116	CDD:299845	27/112 (24%)
		Ig2_KIRREL3-like	138..219	CDD:143236	19/87 (22%)
		I-set	223..304	CDD:254352	21/87 (24%)
		Ig_2	227..305	CDD:290606	20/84 (24%)
		Ig_2	311..405	CDD:290606	22/100 (22%)
		IG_like	314..405	CDD:214653	22/96 (23%)
		Ig5_KIRREL3	407..504	CDD:143306	28/112 (25%)
		IG_like	416..504	CDD:214653	25/98 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910