DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG45263 and Nphs1

DIOPT Version :9

Sequence 1:	NP_731246.2	Gene:	CG45263 / 50003	FlyBaseID:	FBgn0266801	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	NP_062332.2	Gene:	Nphs1 / 54631	MGIID:	1859637	Length:	1256	Species:	Mus musculus

Alignment Length:	1207	Identity:	241/1207 - (19%)
Similarity:	384/1207 - (31%)	Gaps:	413/1207 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LLLIGIAVA----SCLPGS--EGFQRFSEQPKYTEVNPAEDTLLTCKVIDKRGTCSWQKDNKPVG 92
            |||.|:...    |.:|.|  .||...||.....|.:..:   |.|.|........|.||...:|
Mouse    25 LLLAGMLTTGLAQSPVPTSAPRGFWALSENLTVVEGSTVK---LWCGVRAPGSVVQWAKDGLLLG 86

  Fly    93 IYTKKYEWASRMPTSDNGNVLHLDLHPPPVQLGGDCS-----LWIRSATLDFDDGLWECQVTASD 152
            ...|       :|..            |...|.||.:     |.|.:..|. ||..:||||..|:
Mouse    87 PNPK-------IPGF------------PRYSLEGDSAKGEFHLLIEACDLS-DDAEYECQVGRSE 131

  Fly   153 FTTQDALTSQPVRLVVRVAPQRPRLEYEA---------------------------VHVPPGHNI 190
            ...:  |.|..|.|.:.|:|:..:|..||                           :.:..|..:
Mouse   132 LGPE--LVSPSVILSILVSPKVLQLTPEAGSTVTWVAGQEYVVTCVSGDAKPAPDIIFIQGGRTV 194

  Fly   191 ---------------------------TADAG----------ALAT------------------- 199
                                       ::|.|          ||||
Mouse   195 EDVSSSVNEGSEEKLFFTEAEARVTPQSSDNGQLLVCEGSNPALATPIKASFTMNILFPPGPPVI 259

  Fly   200 -----------------VKCISHYGNPPATLKWFLGDQEIS----PIHPQMNATEPDNPRTWSAT 243
                             :.||:..|||||||:|....:.:|    ..|.|.           .|.
Mouse   260 DWPGLNEGHVRAGENLELPCIARGGNPPATLQWLKNGKPVSIAWGTEHAQA-----------VAH 313

  Fly   244 SVVQVSAMRERHGDILRCAAYHESYTAKSVVVEARLDVKYAPS-IRLIGSPEIDLEEDKDALVLR 307
            ||:.::...|.||..|.|.:|: |.:|::......|.|.:.|| :.::||..   :.:...:.|.
Mouse   314 SVLVMTVRPEDHGARLSCQSYN-SVSAETQERSITLQVTFPPSAVTILGSTS---QSENKNVTLC 374

  Fly   308 CVADANPPASIV-WRRAGRSEIASLQETLQ-------------LRPVGRRDAGL-YTCQAQNSVG 357
            |:..::.|..:: |...|| ::....||:.             ...|.|.|.|| .||:|.:...
Mouse   375 CLTKSSRPRVLLRWWLGGR-QLLPTDETVMDGLHGGHISMSNLTLLVKREDNGLSLTCEAFSDAF 438

  Fly   358 TSE--QLSVQLDVKYP-PKIISAGPDRLTTAPLFSPAAFECLA-DGNPLPSFKWVQ--------R 410
            :.|  :.|:.|:|||| .|:...||....:....:.....||| .|||.||..|::        |
Mouse   439 SKETFKKSLTLNVKYPAQKLWIEGPPEGQSIRTGTRVRLVCLAIGGNPEPSLTWLKDSRPVNDPR 503

  Fly   411 MAHGSKYVERGS----------ESRLVI---DNVTYEYQGEYECRATSYINGQERVAISDPVSLQ 462
            .:...:.|:.||          |..|:|   ||:     .::.|:|.......:.|....|.:|.
Mouse   504 QSQEPRRVQLGSVEKSGSTFSRELVLIIGPPDNL-----AKFSCKAGQLSASTQLVVQFPPTNLT 563

  Fly   463 VVGAPQVLRLHPSLHTVSVKRGEAASLTMVVCADPRPQRVAWEWGSLRLE-----------AGSG 516
            ::.....||           .|:|.:||.|..:...|..::.:....||:           .||.
Mouse   564 ILANSSALR-----------PGDALNLTCVSISSNPPVNLSLDKEGERLDDVAAKPQSAPFKGSA 617

  Fly   517 IDR---FRADDMQPDTREDCYLST------------LHILHADEHDSRPYYLVVENERGTDRHAI 566
            ..|   .|........|..|...:            |::|:.      |.:|      |....|:
Mouse   618 ASRSVFLRVSSRDHGHRVTCRAHSEALRETVSSFYRLNVLYP------PEFL------GEQVRAV 670

  Fly   567 HLIVEGTFAEPYEMS--------------YLMGVAGGCMAAILLLVCLCIYAIKSKRCCFKGSTG 617
            .::.:|....|..:|              |.:..|||....||....|.::.:.      :...|
Mouse   671 TVVEQGQALLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSGGALQLWNVT------RADDG 729

  Fly   618 Y-----KSSDKDSE---KAD---------LKSRSDSTSGPQGDSIYTT------PAGFHHHQQQQ 659
            :     ::|:..:|   |.|         ||..::...|...|.:.|.      |..|...:..:
Mouse   730 FYQLHCQNSEGTAEALLKLDVHYAPTIRALKDPTEVNVGGSVDIVCTVDANPILPEMFSWERLGE 794

  Fly   660 QQQQ------QQQHAAAAAAAALHAASQHPQQQY---------PGHGSPEAMKVRMAAMILQPP- 708
            .:::      ::....:.....:..|.......|         |.......:.||.|..:..|.
Mouse   795 DEEELNLDDMEKMSKGSTGRLRIRQAKLSQAGAYQCIVDNGVAPAARGLVRLVVRFAPQVDHPTP 859

  Fly   709 -TRVXQAIDTTSES----------NEQLTQQQQ------QDDNKNKNKNENEHQNEL-TDQHTTS 755
             |:| .|.|:||.:          |...|..:.      ||....::|   .||..: :...|.:
Mouse   860 LTKVAAAGDSTSSATLHCRARGVPNIDFTWTKNGVPLDLQDPRYTEHK---YHQGVVHSSLLTIA 921

  Fly   756 NEQRLDDSSVSHNNNNNHKISSTSTTVLTNSDNNNTS-------------EVAKASDSS------ 801
            |.....|.::         ...|:|..| .||:.|..             :|...|..|
Mouse   922 NVSAAQDYAL---------FKCTATNAL-GSDHTNIQLVSISRPDPPLGLKVVSVSPHSVGLEWK 976

  Fly   802 -NSEGG-----------------------------SSLTSSKTSSSKRD--LENNMNRDIKPATA 834
             ..:||                             .:||..|.|:..|.  |.:|...|  ....
Mouse   977 PGFDGGLPQRFQIRYEALESPGFLYMDVLPAQATTFTLTGLKPSTRYRIWLLASNALGD--SGLT 1039

  Fly   835 PKLLHLNVTS-GEQQ----------EHQQPGPVDPLPVGPLTPEETQV----LLQKLSINNPFYR 884
            .|.:.:::|: |..|          ..|.|||    |..||.|....|    ||...|.......
Mouse  1040 DKGIQVSITTPGLDQAPEDTDQPLPTEQPPGP----PRLPLLPVLFAVGGLLLLSNASCVGGLLW 1100

  Fly   885 FRKQSNSLKELRRKTGSDAPSVRSRSETDLGQVRGQQ 921
            .|:.....:|:..||.:.:...|.|:|.:..|..|.:
Mouse  1101 RRRLRRLAEEISEKTEAGSEEDRIRNEYEESQWTGDR 1137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45263	NP_731246.2	I-set	53..149	CDD:254352	24/100 (24%)
		Ig	198..281	CDD:299845	27/122 (22%)
		IG_like	302..368	CDD:214653	19/82 (23%)
		IGc2	302..357	CDD:197706	16/69 (23%)
		Ig	372..446	CDD:299845	23/95 (24%)
		Ig	475..568	CDD:299845	20/118 (17%)
		IG_like	478..570	CDD:214653	20/117 (17%)
Nphs1	NP_062332.2	Ig	52..128	CDD:299845	24/98 (24%)
		IG_like	52..127	CDD:214653	23/97 (24%)
		C2-set_2	155..242	CDD:285423	9/86 (10%)
		Ig	254..332	CDD:299845	20/88 (23%)
		IG_like	268..350	CDD:214653	25/93 (27%)
		C2-set_2	358..440	CDD:285423	18/85 (21%)
		Ig	459..544	CDD:299845	21/89 (24%)
		I-set	460..555	CDD:254352	22/99 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..516		4/24 (17%)
		Ig	563..646	CDD:299845	16/93 (17%)
		IG_like	670..750	CDD:214653	14/85 (16%)
		Ig	676..750	CDD:299845	14/79 (18%)
		Ig_3	753..834	CDD:290638	9/80 (11%)
		IG_like	762..848	CDD:214653	8/85 (9%)
		Ig	848..956	CDD:299845	26/120 (22%)
		IG_like	859..949	CDD:214653	22/102 (22%)
		fn3	956..1039	CDD:278470	13/84 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1048..1071		5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1112..1143		7/26 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910