DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG45263 and side-VII

DIOPT Version :9

Sequence 1:	NP_731246.2	Gene:	CG45263 / 50003	FlyBaseID:	FBgn0266801	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	NP_001262432.1	Gene:	side-VII / 41184	FlyBaseID:	FBgn0037736	Length:	939	Species:	Drosophila melanogaster

Alignment Length:	1060	Identity:	204/1060 - (19%)
Similarity:	348/1060 - (32%)	Gaps:	291/1060 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 EDTLLTCKVI----DKRGTCSWQKDNKPVGIYT---------KKYEWASRMPTSDNGNVLHLDLH 118
            |:..|.|.|.    |:.....|.:|:|...||:         ....|:......|....: .|..
  Fly    34 ENIYLPCNVTTYDGDEPVLVLWYRDDKGTPIYSIDIRAGVSKAPKRWSDDSVFGDRAYFI-FDKE 97

  Fly   119 PPPVQLGGDCSLWIRSATLDFDDGLWECQVTASDFTTQDALTSQPVRLVVRVAPQRPRLEYEAVH 183
            |      |..|:....|:   |.|.:.|:|   ||.....:.|: :||.|...|::       |.
  Fly    98 P------GKLSIQNTQAS---DSGTYRCRV---DFLKAQTINSR-IRLNVISPPKQ-------VI 142

  Fly   184 VPPGHNITADA-------GALATVKCISHYGNPPATLKWFLGDQEISPIHPQMNATEPDNPRTWS 241
            :....|:....       |.:.::||....|.|..|:.|:....||           |......:
  Fly   143 IRDSSNVERSTVVGPYSEGDIVSLKCQVIGGYPTPTISWYRDGIEI-----------PCELSHLA 196

  Fly   242 ATSVVQV-----SAMRERHGDILRCAAYHESYTAKSVVVEA--RLDVKYAP-SIRLIGSPEIDLE 298
            ...:::.     |..||.....|.|.|...   .::.:|||  ::|:.:|| :|||:|:.: .|.
  Fly   197 GGKIIECEITLPSLGREDLNSRLTCRALSH---PRAPIVEAVVQIDMNFAPLNIRLLGAHQ-PLS 257

  Fly   299 EDKDALVLRCVADANPPASIVWRRAG----------RSEIASLQETLQLRPVGRRDAGLY-TCQA 352
            ..:...:|...|.:.|||.|.|.:.|          .|:......||.: .:.:.|||.| :|:|
  Fly   258 AGRRYDLLCQSAGSRPPAVITWWQNGIRLEKTTETTSSDGNQTTSTLSI-SLSKSDAGKYLSCKA 321

  Fly   353 QNSVGTSEQL--SVQLDVKYPPKI-----ISAGPDRLTTAPLFSPAAFECLADGNP-LPSFKW-- 407
            .|....||.|  ..:||::|.|:.     .|..|..|...   :...|:||...:| :...:|
  Fly   322 YNHAVPSEPLEDGWKLDIQYVPEAYVRLGTSLDPSTLREG---TDVYFDCLVMAHPNVFRIEWRH 383

  Fly   408 -VQRMAHGSKYVERGSESRLVIDNVTYEYQGEYECRATSYINGQERVAISDPVSLQVVGAPQVLR 471
             .|.::|........|...||:..||....|.|.|...:    .|...||.|.:|.::.||...:
  Fly   384 NEQPLSHNISLGVIISNHSLVLQGVTRATAGNYSCVGFN----AEGEGISAPFALNILYAPTCAQ 444

  Fly   472 LHPSLHTVSVKRGEAASLTMVVCADPRPQRVAWEWGSLRLEAGSGIDRFRADDMQPDTREDCYLS 536
            ....::  .:.:.|.|.:...|.|:||....:|.:.:    :...||                ::
  Fly   445 NQKKVY--GIAKQEDAKVMCTVDANPREVEFSWTFNN----SAESID----------------VA 487

  Fly   537 TLHILHADEHDSRPYYLVVENERGTDRHAIHLIVEGTFAEPYEMSYLMGVAGGCMAAILLLVCL- 600
            |.||:.:.......|..:.|.:.||                                   |:||
  Fly   488 TNHIIRSGTTSIVTYTPITELDYGT-----------------------------------LLCLA 517

  Fly   601 ----------CIYAI-------KSKRC-------------CFKGSTG-----YKSSDKDSEKADL 630
                      |::.|       |...|             |..|..|     :.....||...::
  Fly   518 SNKIGKQRVPCVFHIIAAGRPEKVHNCTVNNISMTSLTVTCSDGFNGGLPQSFNLELLDSYTQEI 582

  Fly   631 KSRSDSTSGPQGDSIYTTPAGFHHHQQQQQQQQQQQHAAAAAAAALHAASQHPQQQYPGH----- 690
            |:...||. |:......:|...:.........:.:...|...||.|    :.|::|....
  Fly   583 KANITSTI-PKFTVPGLSPGSIYRLNIYAFNTKGRSDPAIVNAAML----RMPEKQLTSEQTHNL 642

  Fly   691 --------------GSPEAMKVRMAAMI--LQPPTRVXQAIDTTSESNEQLTQQQ---------- 729
                          |...|:.|.:.|:|  |:.|............|||.:::.:
  Fly   643 RAELLFSPVMSLTIGLTLAVLVAVLAIILALRIPCTASSRRRQKELSNENISRDESPGPSDKSSG 707

  Fly   730 --QQDDNKNKNKNENEHQNELTDQHTTSNEQRLDDSSVSHNNNNNHKISSTSTTVLTNSDNNNTS 792
              :.||...||.:......| .|:...|..:|...|::..|.:.|..|.......||      .:
  Fly   708 SKEVDDCDEKNPDVVPESIE-PDEQAESIRKRQQISTIDTNRSPNRGIFVNEQQHLT------AA 765

  Fly   793 EVAKASDSSNSEGGSSLTS---SKTSSSKRDLENNM-----NRDIKPATAPKL--------LHLN 841
            |::..  :|:..|..:|.|   ::..||..::..|:     :..|...|.|:.        .:.|
  Fly   766 EISLR--ASHGIGYCTLRSGMHAQAQSSVGEISINVTPHVYSNSISQCTLPRQSSQNVWNNYNCN 828

  Fly   842 VTSGEQQE--HQQPGPVDPLPVGPLTPEETQVLLQKLSINNPFYRFRKQSNSLKELRRKTGSDAP 904
            :|......  ||...|...:.||...|.:            |.:                 ..||
  Fly   829 ITGARPTSTFHQLTFPQGRVNVGGHNPAQ------------PLH-----------------GHAP 864

  Fly   905 SVRSRSETDLGQVRGQQLMPHQQHSEAKVVVVLDSKQKEVAISRPRSSVSLKTRSVSSLSPSTNQ 969
            |....|.:.:..  ....:| |.|...:.:.:....|.:..    |..:.:.:..:.|   :...
  Fly   865 SPSQASNSSMAS--STNTLP-QPHPHGRTIAMHHMNQAQCG----RVCIGIASDGIHS---AEQN 919

  Fly   970 MGDSSTVITNPFSIFHDDEI 989
            :.|....:..|..|..|..:
  Fly   920 VSDDEVTVQTPLMIKRDSTV 939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45263	NP_731246.2	I-set	53..149	CDD:254352	20/94 (21%)
		Ig	198..281	CDD:299845	18/89 (20%)
		IG_like	302..368	CDD:214653	22/78 (28%)
		IGc2	302..357	CDD:197706	18/65 (28%)
		Ig	372..446	CDD:299845	19/82 (23%)
		Ig	475..568	CDD:299845	16/92 (17%)
		IG_like	478..570	CDD:214653	16/91 (18%)
side-VII	NP_001262432.1	IG_like	32..134	CDD:214653	26/113 (23%)
		V-set	32..134	CDD:284989	26/113 (23%)
		IGc2	160..>214	CDD:197706	12/64 (19%)
		Ig	262..328	CDD:299845	18/66 (27%)
		IG_like	264..323	CDD:214653	17/59 (29%)
		IGc2	360..425	CDD:197706	15/71 (21%)
		Ig_3	456..519	CDD:290638	19/117 (16%)
		FN3	538..620	CDD:238020	12/82 (15%)
		FAM176	643..741	CDD:291517	18/98 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910