DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG45263 and side-VIII

DIOPT Version :9

Sequence 1:	NP_731246.2	Gene:	CG45263 / 50003	FlyBaseID:	FBgn0266801	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	NP_001097382.2	Gene:	side-VIII / 37310	FlyBaseID:	FBgn0086604	Length:	1201	Species:	Drosophila melanogaster

Alignment Length:	1281	Identity:	243/1281 - (18%)
Similarity:	366/1281 - (28%)	Gaps:	487/1281 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SSRSRSSISTSISSSGSSTKIAQLLLLIGIAVAS-CLPGSEGFQRFSEQPKYTEVNPAEDTLLTC 73
            :||.|.|.||:::.: ...:.|.||||.|..|.| .:.|:.|                   .|.|
  Fly    28 ASRVRVSSSTTMTRN-IEEENALLLLLAGPPVLSESIMGTVG-------------------RLPC 72

  Fly    74 KVI-----DKRGTCSWQKDNKPVGIY---TKKYEWASRMPTSDNGNVLHLDLHPPPVQLGGDCSL 130
            .|.     |:.....|.|......||   |:...:|.....||......|..|..    |...:|
  Fly    73 NVTPPIYEDRVALVIWYKVGLKTPIYSVDTRDSNFAQGTHWSDETYRERLSFHVE----GRAGTL 133

  Fly   131 WIRSATLDFDDGLWECQVTASDFTTQDALTSQPVRLVVRVAPQ---------------------- 173
            .|:|.|.| |.|.:.|:|   ||.......|: |.|.|.:.|:
  Fly   134 TIKSTTED-DTGEYRCRV---DFQKSPTRNSK-VNLTVIIPPESVIILDSKGVTIEDHTLGPYNE 193

  Fly   174 -------------RP----------------------------------RLEYEAVHVP------ 185
                         ||                                  |||...:|:.
  Fly   194 GSGINITCVAIGGRPQPRVTWLHGNTVYKNASVGQPLSERRVGNTLSLARLERRNLHMQLTCRAE 258

  Fly   186 -------------------------PGHNITADAGALATVKCISHYGNPPATLKWFLGDQEISPI 225
                                     .|.|....||....:.|:.....|..|:.|:.|...:...
  Fly   259 NNNLTTPIISSVVLDMNLRPLIVKLQGENRALSAGNSYQLSCVVIGARPAPTITWWKGSTPMKNT 323

  Fly   226 HPQMNATEPDNPRTWSATSVVQVSAMRERHGDILRCAAYHESYTAKSVVVEA------RLDVKYA 284
            |   ....||...|   |||:..:...:..|..|.|.|      .:|::.|:      :||:.:.
  Fly   324 H---EIATPDGNLT---TSVLTFTPTIDDRGKFLSCRA------EQSMIPESGMEDGWKLDIYHI 376

  Fly   285 PSIRL-IGSPEID--LEEDKDALVLRCVADANP-PASIVWRRAGR-------SEIASLQETLQLR 338
            |.:.| :|:..::  |.|..| :...|...:|| ...:.||..|:       ..||...::|.|:
  Fly   377 PVVSLELGTNSLNSTLREGID-VFFECNIKSNPWIYEVSWRHNGKILTNNPAEGIAVSNQSLVLQ 440

  Fly   339 PVGRRDAGLYTCQAQNSVGTSEQLSVQLDVKYPPKIISAGPDRLTTAPLFSPAAFE-----CLAD 398
            ...|..:|:|||...|..|..|...||||:::.|  :.....||:    :|....|     |..|
  Fly   441 NASRARSGIYTCVGSNREGDGESNPVQLDIRFAP--VCRPRQRLS----YSSGRHETVKVACEID 499

  Fly   399 GNPL-PSFKWVQRMAHGSKY--------VERGSESRLVIDNVTYEYQGEYE---CRATSYINGQE 451
            .||. .::.|......|...        |:||..    |.:.|...:.:|.   |.||:.|..|
  Fly   500 ANPAEATYVWKFNATQGETVDIPASQVAVDRGRS----IAHYTPMTENDYGTLLCWATNEIGDQ- 559

  Fly   452 RVAISDPVSLQV--VGAPQVL--------------------------------------RLHPSL 476
                |:|....:  .|.|..|                                      ..||.:
  Fly   560 ----SEPCVYTIFPAGEPDPLLNCTVLNQTSTGFQIECIEGFNGGLQQDFIMEVYMNGTTRHPKI 620

  Fly   477 ------------------HTV------SVKRGEAASLTMVVCADPRPQRV----AWEWGSLR--- 510
                              :.|      |..|..|..|.:....||..|.|    ...:..||
  Fly   621 SKSKRPYFEVSGLVPGMGYNVFLIANNSKGRSNATILQVYTLKDPEKQTVKITFTKSFQGLRPAY 685

  Fly   511 --------------------LEAGSGIDRFRADDMQPDTREDCYLSTLHILHADEHDSRPY---- 551
                                |..|.||......|  .|.:||..|:...::    .|.||:
  Fly   686 TKTKATATTTSDCVCDEDEFLNLGKGISHDEGTD--ADQQEDLSLAYAPVI----EDIRPFLGIL 744

  Fly   552 -------YLV---------VENERGTDRH-------AIHLI--VEGTFAEPYEMSYLMGVAGGCM 591
                   :||         |....|.||:       .:..:  |.||......|....|..||..
  Fly   745 AGIVGSIFLVALIIVIVVRVRGSSGRDRNNYSHPGSGVGGVGGVGGTTGNGSGMGGGGGGVGGTT 809

  Fly   592 A----AILLLV-----CLCI--------------YAIKSKRCCFKGS-------------TGYKS 620
            |    ::.||.     .|.|              :.|..:.|....|             .|:..
  Fly   810 ANGNGSLGLLASNNNGSLVIGTLGHNGGQSVQDMHRIGRETCHVTSSLDSIDKNPDIIPQDGHDL 874

  Fly   621 SDKDSEK---------ADLKSRSDSTSG------------------PQGDSIY--------TTPA 650
            .|:.:.|         |..:..:..|||                  |.|...|        .:..
  Fly   875 DDEWTTKGHGRTYATAAMAEQNAVITSGTYDHLMPTYAVVDKKTAPPPGHGQYIQYNTLIPVSKM 939

  Fly   651 GFHHHQQQQQQQQQQQHAAAAAAAALHAASQHPQQQYPGHGSPEAMKVRMAAMILQPPTRVXQAI 715
            |.:.:||||.|||.||                         ..|.....::|.::..|..|.:..
  Fly   940 GAYANQQQQLQQQPQQ-------------------------KTELSYSELSAPLVSGPVGVQRMA 979

  Fly   716 DTTSESNEQLTQQQQQDDNKNKNKNENEHQNELTDQHTTSNEQRLDDSSVSHNNNNNHKISSTST 780
            ...|.:   |.:..:|.:.|....|.....|.:.|....::.|....|..|:       ::....
  Fly   980 PYCSAT---LGRPGRQAELKRAEPNIYSQVNVMMDDEILADLQAATASGRSY-------VAGAVV 1034

  Fly   781 TVLTNSDNNNTSEVAKASD----------SSNSEGGSSLTSSKTSSSKRDLENNMNRDIKPATAP 835
            ..:..:.|......|...|          :|...|.:|..:..|.|....|..     ..|...|
  Fly  1035 DNVGGAPNLYVQGYATRIDLAHHPMPMYSTSPMFGTNSTITGVTMSHPSQLAT-----FSPTPPP 1094

  Fly   836 KLL-HLNVTSGE---------------QQEHQQPGPVDPLPVGPLTPEETQVLLQKLSINNPFYR 884
            .:. |..||:|:               ......||||      ||.|::
  Fly  1095 PIFTHSMVTTGDGLLQPVTCMGLVATSSAGASVPGPV------PLAPQQ---------------- 1137

  Fly   885 FRKQSNSLKELRRKTGSDAPSVRSRSETDLGQVRGQQLMPHQQHSE 930
              :|...|.......||......|...:|:|:.:..:.:|.:.|.:
  Fly  1138 --QQQQQLTAANGGNGSIVGMGMSLYGSDVGKPQLLKTVPEEVHHQ 1181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45263	NP_731246.2	I-set	53..149	CDD:254352	23/103 (22%)
		Ig	198..281	CDD:299845	19/88 (22%)
		IG_like	302..368	CDD:214653	22/73 (30%)
		IGc2	302..357	CDD:197706	17/62 (27%)
		Ig	372..446	CDD:299845	20/90 (22%)
		Ig	475..568	CDD:299845	29/170 (17%)
		IG_like	478..570	CDD:214653	29/153 (19%)
side-VIII	NP_001097382.2	Ig	55..166	CDD:299845	34/138 (25%)
		IG_like	60..166	CDD:214653	32/133 (24%)
		Ig	182..266	CDD:299845	6/83 (7%)
		Ig	296..373	CDD:299845	19/88 (22%)
		IG_like	389..464	CDD:214653	21/75 (28%)
		IGc2	394..459	CDD:197706	18/65 (28%)
		Ig_3	490..554	CDD:290638	15/67 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910