DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG45263 and IL1RAP

DIOPT Version :9

Sequence 1:NP_731246.2 Gene:CG45263 / 50003 FlyBaseID:FBgn0266801 Length:1876 Species:Drosophila melanogaster
Sequence 2:NP_001161403.1 Gene:IL1RAP / 3556 HGNCID:5995 Length:687 Species:Homo sapiens


Alignment Length:337 Identity:68/337 - (20%)
Similarity:126/337 - (37%) Gaps:86/337 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   320 WRRAGR------------SEIASLQETLQLRPVGRRDAGLYTCQAQNSVGTSEQLSVQLDVKYPP 372
            |.|..|            :.|:..::.|..||....|.|.|||..:|:...|:       |.:|.
Human    72 WTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSK-------VAFPL 129

  Fly   373 KIISA-----GPDRLTTAPLFSPAAFECL----ADG----NPLPSFKWVQ---RMAHGSKYVERG 421
            :::..     .|.:|....|:.....:.:    .||    :..|:..|..   ::.:.:..:..|
Human   130 EVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPEG 194

  Fly   422 SESRLVIDNVTYEYQGEYECRATSYINGQERVAISDPVSLQVVGAPQ-----VLRLHPSLHTVSV 481
            .....:|..::  ..|.|.|..|...||: ...::..::::|||:|:     |:. .|:.|.|..
Human   195 MNLSFLIALIS--NNGNYTCVVTYPENGR-TFHLTRTLTVKVVG
SPKNAVPPVIH-SPNDHVVYE 255

  Fly   482 KRGEAASLTMVVCA-------DPRPQRVAWEWGSLRLEAGSGIDRFRADDMQPDTREDCYLSTLH 539
            |  |.....::.|.       |.| ..|.|.           ||..:.||:..|.       |::
Human   256 K--EPGEELLIPCTVYFSFLMDSR-NEVWWT-----------IDGKKPDDITIDV-------TIN 299

  Fly   540 --ILHA-DEHDSRPYYLVVENERGTDRHAIHLI----VEGTFAEPYEMS-------YLMGVAGGC 590
              |.|: .|.::|...|.::.....|....::.    .:|..|:..::.       |.:.:|.|.
Human   300 ESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKVPAPRYTVELACGF 364

  Fly   591 MAAILLLVCLCI 602
            .|.:||:|.|.:
Human   365 GATVLLVVILIV 376

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG45263NP_731246.2 I-set 53..149 CDD:254352
Ig 198..281 CDD:299845
IG_like 302..368 CDD:214653 14/59 (24%)
IGc2 302..357 CDD:197706 13/48 (27%)
Ig 372..446 CDD:299845 13/89 (15%)
Ig 475..568 CDD:299845 21/102 (21%)
IG_like 478..570 CDD:214653 20/105 (19%)
IL1RAPNP_001161403.1 Ig1_IL1R_like 25..132 CDD:409584 16/66 (24%)
Ig strand B 43..47 CDD:409584
Ig strand C 67..71 CDD:409584
Ig strand E 97..101 CDD:409584 1/3 (33%)
Ig strand F 111..116 CDD:409584 3/4 (75%)
Ig strand G 124..127 CDD:409584 1/9 (11%)
Ig2_IL-1RAP_like 143..235 CDD:409585 15/94 (16%)
Ig strand B 156..160 CDD:409585 0/3 (0%)
Ig strand C 174..178 CDD:409585 0/3 (0%)
Ig strand E 195..199 CDD:409585 0/3 (0%)
Ig strand F 209..214 CDD:409585 2/4 (50%)
Ig strand G 226..229 CDD:409585 0/2 (0%)
Ig3_IL1RAP 243..349 CDD:409525 25/127 (20%)
Ig strand B 262..266 CDD:409525 0/3 (0%)
Ig strand C 279..283 CDD:409525 1/3 (33%)
Ig strand E 314..318 CDD:409525 1/3 (33%)
Ig strand F 329..334 CDD:409525 0/4 (0%)
Ig strand G 341..344 CDD:409525 1/2 (50%)
TIR 404..547 CDD:214587
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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