DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45263 and Kirrel3

DIOPT Version :9

Sequence 1:	NP_731246.2	Gene:	CG45263 / 50003	FlyBaseID:	FBgn0266801	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	XP_038937320.1	Gene:	Kirrel3 / 315546	RGDID:	1311382	Length:	869	Species:	Rattus norvegicus

Alignment Length:	895	Identity:	199/895 - (22%)
Similarity:	318/895 - (35%)	Gaps:	251/895 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 FSEQPKYTEVNPAEDTLLTCKVIDKRGTCSWQKDNKPVGIYTKKYEWASRMPTSDNGNVLHLDLH 118
            ||:||:...|...:...|.|.:.:..|...|.||...:|:......:...:..   ||
  Rat    50 FSQQPQDQVVVSGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVV---GN------- 104

  Fly   119 PPPVQLGGDCSLWIRSATLDFDDGLWECQVTASDFTTQDALTSQPVRLVVRVAPQRPRLEYEAVH 183
                .|.|:..|.|..|.|. ||.::|||      ..|.|:.|:|.||.|.|.|..|       .
  Rat   105 ----HLSGEHHLKILRAELQ-DDAVYECQ------AIQAAIRSRPARLTVLVPPDDP-------I 151

  Fly   184 VPPGHNITADAGALATVKCISHYGNPPATLKWFLGDQEISPIHPQMNATEPDNPRTWSAT----- 243
            :..|..|:..||....:.|.:....|.|::.|             :...|..|..|:|.|
  Rat   152 ILGGPVISLRAGDPLNLTCHADNAKPAASIIW-------------LRKGEVINGATYSKTLLRDG 203

  Fly   244 ------SVVQVSAMRERHGDILRCAAYHESYTAKSV----VVEARLDVKYAPSIRLIGSPEIDLE 298
                  |.:.:|.....:|..:.|.|     |.|::    .....:|:::.|.:.|...|:..||
  Rat   204 KRESIVSTLFISPGDVENGQSIVCRA-----TNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLE 263

  Fly   299 EDKDALVLRCVADANPPASIVWRRAGRSEI----------ASLQETLQLRPVGRRDAGLYTCQAQ 353
            :  :.:...|.|.|| ||...:|.|.|..|          .::..|....||        :|:..
  Rat   264 D--NIVTFHCSAKAN-PAVTQYRWAKRGHIIKEASGELYRTTVDYTYFSEPV--------SCEVT 317

  Fly   354 NSVGTSEQLSVQLDVKYPPKIISAGPDRLTTAPLFSPAAFECLADGNPLPSFKWVQRMAHGSKYV 418
            |::| |..||..:||.:.|::.|. |..| ...|.|.|.|.|...|||..:..|::|   ||..|
  Rat   318 NALG-STNLSRTVDVYFGPRMTSE-PQSL-LVDLGSDAVFSCAWIGNPSLTIVWMKR---GSGVV 376

  Fly   419 ERGSESRLVIDNVTYEYQGEYECRA-TSYINGQERVAISDPVSLQVVGAPQVLRLHPSLHTVSVK 482
             ..:|..|.:.:|..|..|:|.||| ...:...||     .|:|.|.|.|.:    .|..|....
  Rat   377 -LSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGER-----EVTLTVNGPPII----SSTQTQHAL 431

  Fly   483 RGEAASLTMVVCADPRPQRVAWEWGSLRLEAGSGIDRFRADDMQPDTREDCYLSTLHILHADEHD 547
            .||...:...:.:.|.|.|:||.|....||:|:. .|:..:.:   ..|:..:|||.|.:....|
  Rat   432 HGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTS-GRYTVETV---NTEEGVISTLTISNIVRAD 492

  Fly   548 SRPYY-LVVENERGTDRHAIHLIVEGT--------FAEPYEMSYLMGVAGGCMAAILLLVCLCIY 603
            .:..| ....|..|:|...|.|..:|:        .||...|:.::|||.|...|.|:|:...:
  Rat   493 FQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIV- 556

  Fly   604 AIKSKRCCFKGSTGYKSSDKDSEKADLKSRSD-STSGPQGDSIYTTPAGFHHHQQQQQQQQQQQH 667
                ..||                    :||. ||.|..|.|
  Rat   557 ----AFCC--------------------ARSQRSTGGRPGIS----------------------- 574

  Fly   668 AAAAAAAALHAASQHPQQQYPGHGSPEAMKVRM-----------------AAMILQPPTRVXQAI 715
                                 |.|:.:..::|:                 ..::.:.|....:|.
  Rat   575 ---------------------GRGTEQKARLRLPRRANLKGVVSAKNDIRVEIVHKEPASGREAE 618

  Fly   716 DTTSESNEQLTQQQQQDDNKNK-----NKNENEHQNELTDQHTTSNEQRLDDSSVSHNNNNNHKI 775
            |.|:.....:.:.:.|.|:..|     .:.|.|.||             |.|.:..:.:.|..|.
  Rat   619 DHTTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQN-------------LKDPTNGYYSVNTFKE 670

  Fly   776 SSTSTTVLTNSDNNNTSEVAKAS-----------DSSNSEG-----GSSLTSSKTSSSKRDLENN 824
            ..::.|:..:|...:.....|..           .:.:.:|     |.|:|::..:::.:....:
  Rat   671 HHSTPTISLSSCQPDLRPTGKQRVPTGMSFTNIYSTLSGQGRLYDYGQSVTAASAAAANKMATCS 735

  Fly   825 MNRDIK-----PATAPKLLHLNVTSGEQQEHQQPGPVDPLPVG-PLTPEE 868
            :.|..:     |.|...|            .:.|.||||...| .||.|:
  Rat   736 LTRPARLLPPLPTTPSPL------------PRTPTPVDPCSGGCRLTSED 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45263	NP_731246.2	I-set	53..149	CDD:254352	25/94 (27%)
		Ig	198..281	CDD:299845	16/97 (16%)
		IG_like	302..368	CDD:214653	19/75 (25%)
		IGc2	302..357	CDD:197706	15/64 (23%)
		Ig	372..446	CDD:299845	26/74 (35%)
		Ig	475..568	CDD:299845	25/93 (27%)
		IG_like	478..570	CDD:214653	25/92 (27%)
Kirrel3	XP_038937320.1	IG_like	54..143	CDD:214653	28/109 (26%)
		Ig strand A'	56..60	CDD:409353	0/3 (0%)
		Ig strand B	64..71	CDD:409353	2/6 (33%)
		Ig strand C	78..82	CDD:409353	1/3 (33%)
		Ig strand C'	84..87	CDD:409353	0/2 (0%)
		Ig strand D	97..101	CDD:409353	0/3 (0%)
		Ig strand E	104..116	CDD:409353	5/22 (23%)
		Ig strand G	132..143	CDD:409353	5/10 (50%)
		IgI_2_KIRREL3-like	149..246	CDD:409416	21/121 (17%)
		Ig strand B	166..170	CDD:409416	0/3 (0%)
		Ig strand C	180..184	CDD:409416	1/16 (6%)
		Ig strand E	210..214	CDD:409416	1/3 (33%)
		Ig strand F	224..229	CDD:409416	1/4 (25%)
		Ig strand G	239..242	CDD:409416	0/2 (0%)
		Ig	<267..334	CDD:416386	21/76 (28%)
		Ig strand B	267..274	CDD:409353	1/6 (17%)
		Ig strand C	279..286	CDD:409353	1/6 (17%)
		Ig strand C'	288..291	CDD:409353	0/2 (0%)
		Ig strand D	298..302	CDD:409353	0/3 (0%)
		Ig strand E	304..310	CDD:409353	1/5 (20%)
		Ig strand G	321..334	CDD:409353	6/13 (46%)
		Ig	335..416	CDD:416386	30/91 (33%)
		Ig strand A'	343..347	CDD:409353	1/4 (25%)
		Ig strand B	350..360	CDD:409353	4/9 (44%)
		Ig strand C	365..371	CDD:409353	1/5 (20%)
		Ig strand E	381..387	CDD:409353	1/5 (20%)
		IgI_5_KIRREL3	418..515	CDD:409479	27/104 (26%)
		Ig strand B	436..440	CDD:409479	0/3 (0%)
		Ig strand C	450..454	CDD:409479	2/3 (67%)
		Ig strand E	481..485	CDD:409479	3/3 (100%)
		Ig strand F	496..501	CDD:409479	1/4 (25%)
		Ig strand G	509..512	CDD:409479	0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910