Protein Alignment CG45263 and SIGLEC8

DIOPT Version :10

• Sequence 1: NP_731246.2
• Gene: CG45263 / 50003
• FlyBaseID: FBgn0266801
• Length: 1876
• Species: Drosophila melanogaster
• Sequence 2: NP_055257.2
• Gene: SIGLEC8 / 27181
• HGNCID: 10877
• Length: 499
• Species: Homo sapiens
• Alignment Length: 280
• Identity: 73/280 - (26%)
• Similarity: 107/280 - (38%)
• Gaps: 76/280 - (27%)

  Fly   127 DCSLWIRSA----------TLDFDDGLWECQVTASDFTTQ-----DALTSQPVRLVVRVAPQRPR 176
            ||||.||.|          .|:.....|..:...:..|.|     .|||.:|..|::..
Human   106 DCSLSIRDARKRDKGSYFFRLERGSMKWSYKSQLNYKTKQLSVFVTALTHRPDILILGT------ 164

  Fly   177 LEYEAVHVPPGH--NITADAGALATVKCISHYGNPPATLKWFLGDQEISPIHPQMNATEPDNPRT 239
                   :..||  |:|      .:|......|.|| .:.| :|....||           .|.|
Human   165 -------LESGHSRNLT------CSVPWACKQGTPP-MISW-IGASVSSP-----------GPTT 203

  Fly   240 WSATSVVQVSAMRERHGDILRCAAYHESYTAKSVVVEARLDVKYAP--------------SIRLI 290
             :.:||:.::...:.||..|.|...... |..:.....||||.|.|              |..|.
Human   204 -ARSSVLTLTPKPQDHGTSLTCQVTLPG-TGVTTTSTVRLDVSYPPWNLTMTVFQGDATASTALG 266

  Fly   291 GSPEIDLEEDKDALVLRCVADANPPASIVWRRA------GRSEIASLQETLQLRPVGRRDAGLYT 349
            ....:.:.|.: :|.|.|..::||||.:.|.|.      .||....|   |:|..|..||.|.:|
Human   267 NGSSLSVLEGQ-SLRLVCAVNSNPPARLSWTRGSLTLCPSRSSNPGL---LELPRVHVRDEGEFT 327

  Fly   350 CQAQNSVGTSEQLSVQLDVK 369
            |:|||:.| |:.:|:.|.::
Human   328 CRAQNAQG-SQHISLSLSLQ 346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG45263	NP_731246.2	Ig	170..281	CDD:472250	23/112 (21%)
		Ig strand B	198..202	CDD:409353	1/3 (33%)
		Ig strand C	212..216	CDD:409353	0/3 (0%)
		Ig strand E	244..248	CDD:409353	2/3 (67%)
		Ig strand F	258..263	CDD:409353	2/4 (50%)
		Ig strand G	274..277	CDD:409353	0/2 (0%)
		Ig	304..364	CDD:409353	25/65 (38%)
		Ig strand B	304..308	CDD:409353	2/3 (67%)
		Ig strand C	317..321	CDD:409353	0/3 (0%)
		Ig strand E	334..337	CDD:409353	1/2 (50%)
		Ig strand F	347..352	CDD:409353	2/4 (50%)
		Ig strand G	361..364	CDD:409353	0/2 (0%)
		Ig_3	371..444	CDD:464046
		Ig	475..568	CDD:472250
		Ig strand B	487..491	CDD:409353
		Ig strand C	501..505	CDD:409353
		Ig strand E	536..540	CDD:409353
		Ig strand F	550..555	CDD:409353
		Ig strand G	563..566	CDD:409353
SIGLEC8	NP_055257.2	IgV_CD33	27..151	CDD:409377	11/44 (25%)
		FR1	27..51	CDD:409377
		Ig strand A	27..31	CDD:409377
		Ig strand A'	34..38	CDD:409377
		Ig strand B	40..51	CDD:409377
		CDR1	52..61	CDD:409377
		FR2	62..69	CDD:409377
		Ig strand C	62..69	CDD:409377
		CDR2	70..93	CDD:409377
		Ig strand C'	80..83	CDD:409377
		FR3	94..127	CDD:409377	7/20 (35%)
		Ig strand D	95..99	CDD:409377
		Ig strand E	105..113	CDD:409377	5/6 (83%)
		Ig strand F	120..128	CDD:409377	1/7 (14%)
		CDR3	128..131	CDD:409377	0/2 (0%)
		FR4	132..151	CDD:409377	3/18 (17%)
		Ig strand G	132..151	CDD:409377	3/18 (17%)
		Ig	157..242	CDD:472250	24/118 (20%)
		Ig strand B	171..175	CDD:409353	2/9 (22%)
		Ig strand C	188..192	CDD:409353	1/4 (25%)
		Ig strand E	207..211	CDD:409353	2/3 (67%)
		Ig strand F	221..226	CDD:409353	2/4 (50%)
		Ig strand G	236..239	CDD:409353	0/2 (0%)
		IG_like	269..344	CDD:214653	27/79 (34%)
		Ig strand B	279..283	CDD:409353	2/3 (67%)
		Ig strand C	292..296	CDD:409353	0/3 (0%)
		Ig strand E	314..318	CDD:409353	1/3 (33%)
		Ig strand F	325..330	CDD:409353	2/4 (50%)
		Ig strand G	340..343	CDD:409353	1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	410..443
		ITIM motif	445..450
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	451..470
		SLAM-like motif	468..473
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	478..499