DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG45263 and Il1rap

DIOPT Version :9

Sequence 1:	NP_731246.2	Gene:	CG45263 / 50003	FlyBaseID:	FBgn0266801	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	XP_038943965.1	Gene:	Il1rap / 25466	RGDID:	2893	Length:	697	Species:	Rattus norvegicus

Alignment Length:	780	Identity:	135/780 - (17%)
Similarity:	237/780 - (30%)	Gaps:	269/780 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 VEARLDVKYAPSIRLIGSP-------------EIDLEEDKDALVLRC----------VADANPPA 316
            :|:.|.::|..|:||...|             :|.:.||:.|.: :|          .:.|:...
  Rat    14 LESHLGLQYKGSVRLAHFPSERCDDWGLDTMRQIQVFEDEPARI-KCPLFEHFLKYNYSTAHSSG 77

  Fly   317 -SIVWR--------------RAGRSEIASLQETLQLRPVGRRDAGLYTCQAQNSVGTSEQLSVQL 366
             :::|.              |...:.|:..::.|..||....|.|.|||..:|:...|:
  Rat    78 LTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSK------ 136

  Fly   367 DVKYPPKIISA-----GPDRLTTAPLFSPAAFECL----ADG----NPLPSFKWVQ---RMAHGS 415
             |.:|.:::..     .|.||....|:.......:    .||    :..||..|.:   .:.:..
  Rat   137 -VAFPLEVVQKDSCFNSPMRLPVHRLYIEQGIHNITCPNVDGYFPSSVKPSVTWYKGCTEIVNFH 200

  Fly   416 KYVERGSESRLVIDNVTYEYQGEYECRATSYINGQERVAISDPVSLQVVGAPQVLRLHPSLHTVS 480
            ....:|......|..|:  ..|.|.|..| |:.......::..::::|||:|:. .:.|.:::.:
  Rat   201 NVQPKGMNLSFFIPLVS--NNGNYTCVVT-YLENGRLFHLTRTMTVKVVGSPKD-AVPPHIYSPN 261

  Fly   481 ---VKRGEAASLTMVVC-------ADPRPQRVAWEWGSLRLEAGSGIDRFRADDMQPD------- 528
               |...|.....::.|       .|.. ..:.|.           ||..:.||:..|
  Rat   262 DRVVYEKEPGEELVIPCKVYFSFIMDSH-NEIWWT-----------IDGKKPDDVPVDITINESV 314

  Fly   529 ----TREDCYLSTLHILHADEHD-SRPYYLVVENERGTDRHAIHLIVEGTFAEPYEMSYLMGVAG 588
                |.::.....|.|......| .|.|.....|..|....|..  |:.....|   .|.:.:|.
  Rat   315 SYSSTEDETRTQILSIKKVTPEDLKRNYVCHARNAEGEAEQAAK--VKQKVIPP---RYTVELAC 374

  Fly   589 GCMAAILLLVCLCI-------------------------------------------YAIKSKRC 610
            |..|.:.|:|.|.:                                           :.:.:.|.
  Rat   375 GFGATVFLVVVLIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEFVLLTLRG 439

  Fly   611 CFKGSTGYKSS--DKDSEKADLKSRSDSTSGPQGDSIYTTPAGFHHHQQQQQ------------- 660
            ..:...|||..  |:||.             |.|:   |..|.|...|:.::
  Rat   440 VLENEFGYKLCIFDRDSL-------------PGGN---TVEAVFDFIQRSRRMIVVLSPDYVTEK 488

  Fly   661 -----QQQQQQHAAAAAAAALHAASQHP-QQQYPG-------------------HGSPEAMKVRM 700
                 :.:.......:.|..|......| :|.:||                   |...:..|
  Rat   489 SISMLEFKLGVMCQNSIATKLIVVEYRPLEQPHPGIMQLKESVSFVSWKGEKSKHSGSKFWK--- 550

  Fly   701 AAMILQPPTRVXQAIDTTSESNEQLTQQQQQDDNKNKNKNENEHQNELTDQHTTSNEQRLDDSSV 765
             |:.|..|.|   ::..:|..||..:.|.....:..:.::..:...||
  Rat   551 -ALRLALPLR---SLSASSGWNESCSSQSDISLDHVQRRSRLKEPPEL----------------- 594

  Fly   766 SHNNNNNHKISSTSTTVLTNSDNNNTSEVAKASDSSNSEGGSSLTSS-----------KTSSSKR 819
                .::.::|..:....|.|.:......|.....:..||.|.|.|.           :|...|.
  Rat   595 ----QSSERVSGAAPAPGTISKHRGKPSAACRCCVTYCEGESHLRSKSRAEMHTHPQWETHLCKP 655

  Fly   820 DLENNMNRDIKPATAPKLLHLNVTSGEQQEHQQPGP-VDPLPVGPLTPEETQVLLQKLSINNPFY 883
            ||:.:.::.|:..|.|                :|.| :..|.:...|         .||.||.||
  Rat   656 DLQESESQWIQNGTRP----------------EPAPQISALALRHFT---------DLSNNNDFY 695

Fly 884 883
Rat 696 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45263	NP_731246.2	I-set	53..149	CDD:254352
		Ig	198..281	CDD:299845	2/5 (40%)
		IG_like	302..368	CDD:214653	16/90 (18%)
		IGc2	302..357	CDD:197706	15/79 (19%)
		Ig	372..446	CDD:299845	16/89 (18%)
		Ig	475..568	CDD:299845	19/114 (17%)
		IG_like	478..570	CDD:214653	19/113 (17%)
Il1rap	XP_038943965.1	Ig1_IL1R_like	37..144	CDD:409584	21/114 (18%)
		Ig strand B	55..59	CDD:409584	1/4 (25%)
		Ig strand C	79..83	CDD:409584	0/3 (0%)
		Ig strand E	109..113	CDD:409584	1/3 (33%)
		Ig strand F	123..128	CDD:409584	3/4 (75%)
		Ig strand G	136..139	CDD:409584	1/9 (11%)
		Ig	155..247	CDD:416386	17/94 (18%)
		Ig strand A	157..162	CDD:409353	0/4 (0%)
		Ig strand A	157..162	CDD:409353	0/4 (0%)
		Ig strand B	168..172	CDD:409353	0/3 (0%)
		Ig strand B	168..172	CDD:409353	0/3 (0%)
		Ig strand C	186..191	CDD:409353	2/4 (50%)
		Ig strand C	186..191	CDD:409353	2/4 (50%)
		Ig strand C'	194..196	CDD:409353	0/1 (0%)
		Ig strand C'	194..196	CDD:409353	0/1 (0%)
		Ig strand D	201..205	CDD:409353	0/3 (0%)
		Ig strand D	201..205	CDD:409353	0/3 (0%)
		Ig strand E	207..212	CDD:409353	0/4 (0%)
		Ig strand E	207..212	CDD:409353	0/4 (0%)
		Ig strand F	221..230	CDD:409353	4/9 (44%)
		Ig strand F	221..230	CDD:409353	4/9 (44%)
		Ig strand G	233..246	CDD:409353	0/12 (0%)
		Ig strand G	233..246	CDD:409353	0/12 (0%)
		Ig3_IL1RAP	255..361	CDD:409525	21/119 (18%)
		Ig strand B	274..278	CDD:409525	0/3 (0%)
		Ig strand C	291..295	CDD:409525	0/3 (0%)
		Ig strand E	326..330	CDD:409525	1/3 (33%)
		Ig strand F	341..346	CDD:409525	1/4 (25%)
		Ig strand G	353..356	CDD:409525	0/2 (0%)
		TIR	416..559	CDD:214587	24/162 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910