DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG45263 and syg-1

DIOPT Version :9

Sequence 1:	NP_731246.2	Gene:	CG45263 / 50003	FlyBaseID:	FBgn0266801	Length:	1876	Species:	Drosophila melanogaster
Sequence 2:	NP_001123159.1	Gene:	syg-1 / 180555	WormBaseID:	WBGene00006365	Length:	730	Species:	Caenorhabditis elegans

Alignment Length:	788	Identity:	183/788 - (23%)
Similarity:	288/788 - (36%)	Gaps:	184/788 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LLLLIGIAVASCLPGSEGFQRFSEQPKYTEVNPAEDTLLTCKVIDKRGTCSWQKDNKPVGI---- 93
            ||||..:.....|.     ||..|.||.|.....|..:|||:|..::|...|.||:..:|.
Worm     9 LLLLFQLVTCQQLQ-----QRIVEAPKDTLAAVGETAILTCRVEHQQGPVQWMKDDFGLGTDRDK 68

  Fly    94 ---YTKKYEWASRMPTSDNGNVLHLDLHPPPVQLGGDCSLWIRSATLDFDDGLWECQVTASDFTT 155
               ..|:|    ||..|               ...|:.:|.|.:.|| |||..:.||::.||..
Worm    69 PLPGNKRY----RMVGS---------------AANGEYNLEISNVTL-FDDDDFACQISESDHA- 112

  Fly   156 QDALTSQPVRLVVRVAPQRPRLEYEAVHVPPGHNITADAGALATVKCISHYGNPPATLKWFLGDQ 220
             .|:.|...:|.|.|.|..|::      |...|::.|.||...|..|:|..|.||.|:.|.:...
Worm   113 -KAVVSSKAKLTVLVRPTPPKI------VKSHHSLKAIAGDPITQSCLSRKGKPPPTIGWAIASD 170

  Fly   221 E---------------ISPIHPQ-----------MNATEP-----DNPR----TWSATSVVQVSA 250
            |               ...||.:           :|.|..     :|.|    .:|..|.:....
Worm   171 EHGKHIVSWLGESRSKFGGIHAKPEISQETVIAHVNETTQVEEGGNNSREDSSIYSIMSNLSFIP 235

  Fly   251 MRERHGDILRCAAYHESYTAKSVVVEARLDVKYAPSIRLIGSPEIDLEEDKDALVLRCVADANP- 314
            ..|.....|.|.:.|.::..|..|...:|.::|||.|.|..:.::.|.|:..|| |.|..:|.|
Worm   236 RPEDDHKYLICISQHMTFPNKIEVDSVKLSLRYAPQINLTVASKLPLRENGSAL-LACNVNAKPL 299

  Fly   315 -PASIVWRRAGRSEIASLQETLQLRPVGRRDAGL-YTCQAQNSVGTSEQLSVQLDVKYPPKIISA 377
             ...|.|.: |..::....:||....:...|... ..|:|.|.:||:.. |::|:|.:..:|:|.
Worm   300 DNVKISWYK-GNQKLRETGDTLTFETLKMEDHNRDIFCEATNEIGTTRG-SIKLNVAFGARIMST 362

  Fly   378 GPDRLTTAPLFSPAAFECLADGNPLPSFKWV-----QRMAHGSKYVERGSESRLVIDNVTYEYQG 437
            ..|:.....  ..|.|.|....||.|:..|.     :.:.||         ..|.::||....||
Worm   363 SQDKEVNEG--DNAFFHCATLANPAPAIFWTRGDSDEIIGHG---------ENLTLENVRTWQQG 416

  Fly   438 EYECRATSYINGQERVAISDPVSLQVVGAPQVLRLHPSLHTVSVKRGEAASL---TMVVC---AD 496
            .|.|.||  :.|..:..:|.  .|.:.|.|          |||:|...:|||   |.::|   ..
Worm   417 NYNCTAT--VEGFRKQILSH--YLHIRGPP----------TVSMKDEVSASLDEATEIICEISGR 467

  Fly   497 PRPQRVAWEWGSLRLEAGSG---IDRFRADDMQPDTREDCYLSTLHILHADEHDSRPYYLVVENE 558
            |:...|.|......:...:|   :.::    .:|..:|    |.|.|....|.|...|.....|.
Worm   468 PKTNNVRWTVNGKEINFNNGRITVHQY----PKPYGKE----SILKIKDLKEEDFGVYNCSANNG 524

  Fly   559 RGTDRHAIHL---------IVEGTFAEPYEMSYLMGVAGGCMAAILLLVCLCIYAIKSKRCCFKG 614
            .|.|.....|         ::...|.....::.:.  ||..:.::|..:|:|....:|::..|..
Worm   525 LGFDNRGTLLKKRNILDWIVITAKFDRMVALAIIS--AGVLLVSLLCCLCMCRSNCRSRKSKFID 587

  Fly   615 STG-----------------YKSSDKDSEKADLKSRSDSTSGPQGD---------SIYTTPAGFH 653
            ...                 |.||..|:.....|   |..|.||.:         ..:..|.|.:
Worm   588 DQSDVTVKCEALDGQYFPEMYSSSPVDNVHLSTK---DYISIPQNNPDLDFLGATGSFGPPGGLY 649

  Fly   654 ----HHQQQQQQQQQQQHAAAAAAAALHAASQHPQQQYPGHGSPEAMKVRMAAMILQPPTRVXQA 714
                ::...:....:.:|:..:..:.|..         || |..:...|.|:..:  |.... |.
Worm   650 PKCFNNSANEYIYNRYEHSYGSFGSGLST---------PG-GVSDMYGVAMSDKL--PVMETLQE 702

  Fly   715 IDTTSESN 722
            ::|...||
Worm   703 VETPKTSN 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG45263	NP_731246.2	I-set	53..149	CDD:254352	30/102 (29%)
		Ig	198..281	CDD:299845	24/117 (21%)
		IG_like	302..368	CDD:214653	19/68 (28%)
		IGc2	302..357	CDD:197706	15/57 (26%)
		Ig	372..446	CDD:299845	21/78 (27%)
		Ig	475..568	CDD:299845	24/101 (24%)
		IG_like	478..570	CDD:214653	25/109 (23%)
syg-1	NP_001123159.1	I-set	24..124	CDD:254352	35/121 (29%)
		Ig	30..124	CDD:299845	32/115 (28%)
		Ig	<151..265	CDD:299845	22/113 (19%)
		Ig_2	276..353	CDD:290606	21/79 (27%)
		IG_like	283..353	CDD:214653	20/72 (28%)
		IG_like	363..427	CDD:214653	19/76 (25%)
		Ig_2	368..438	CDD:290606	21/84 (25%)
		Ig	440..528	CDD:299845	25/105 (24%)
		IG_like	450..535	CDD:214653	20/92 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11640
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010